Protein Alignment CG4562 and LOC100485969

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_031758323.1
• Gene: LOC100485969 / 100485969
• -ID: -
• Length: 1262
• Species: Xenopus tropicalis
• Alignment Length: 1364
• Identity: 312/1364 - (22%)
• Similarity: 570/1364 - (41%)
• Gaps: 277/1364 - (20%)

  Fly    68 EVEKKRKKKKTPSLLKA-----SMNVFGWRL-----AGLGLVLFILEIGF-RVTQPLFLGGLVAY 121
            |.:|:|:|:|...:::.     .:::|...:     ||.||.|.:|.:.: :||.     .::.:
 Frog    28 EEKKEREKQKAVGVIQIFRFADKLDIFLMVIGLIGAAGNGLCLPMLNLVYGQVTD-----SILCF 87

  Fly   122 YADASNQEGDNQTK----------AYLYALG--VILTSACNVLFMHPYMLGMFHIGMKARIAMTS 174
            .:...|....|:.|          .|..|:|  ||::....|.|   ::|.......|.|.|
 Frog    88 NSSIQNSSECNKFKPLGEQMTIFALYYVAIGAAVIVSGYAQVSF---WVLAAARQTRKMRQA--- 146

  Fly   175 MIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISA 239
             .:|..|....:.......|::...::.|:.:::..:...    :|.:...:.|::  ..|.::.
 Frog   147 -FFRSVLSQEMSWFDINKSGEINTRLNEDITKINDGIGDK----IGHLFQNVSTFI--AGIIVAL 204

  Fly   240 FFGVAVMLLFI---PL----QAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPF 297
            ..|..:.|::|   ||    .|:..|....|..|..........:..|::|.|:.:      :.|
 Frog   205 ATGWELALVYIAASPLIALSAAFCSKMLVSLTSKELSAYAAAGAVAEEVLSSIRTV------VAF 263

  Fly   298 SKMINYVR--TKEMNAIRNVNYIRGTLQSFIMFVTRISVFVSL-VGF------VLLGKLLTAEKA 353
            ......::  |..:...:.:...|..:....:.:..:.::.|. :||      :|..|..|...|
 Frog   264 GGQEREIKRYTNNLEEAKKIGIKRAIVSQLALGLVFLFIYCSYGLGFWYGTIVILQNKGYTIGDA 328

  Fly   354 FVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIA 418
            .||  ::::..::..:  ....|.|...  ||.|...:.:.   .|.|::..:|..
 Frog   329 LVI--FFSVANSSFCI--GQASSHFEAF--SIARGAAYKIF---NVMDQTATIDNY--------- 375

  Fly   419 EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSG 483
                 .|.|      .|....:.::....:...:..:.....|..::||.|..|.||::|..|.|
 Frog   376 -----MTEG------HRPENMKGNVEFKNVSFSYPSRPNVQILKGLNLKIKSGQTVALVGQSGCG 429

  Fly   484 KSSLIQAVLGELNPDSGSVKVNG-------------TLSYASQEPWLFTGTVRQNILFG------ 529
            ||:.:|.:....:...|:|.|:|             .:...||||.||..|::.||.:|
 Frog   430 KSTTVQLLQRLYDAQEGTVTVDGHDIRSLNVGHYREFIGVVSQEPVLFGTTIKNNIKYGRENVTD 494

  Fly   530 LPMDKHRYRTVVKRCALERDFEL-LPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDD 593
            |.::|     .||. |...||.: ||....|:||||||.||||||.||::|||:.|...|.|||:
 Frog   495 LEIEK-----AVKE-ANAYDFIMALPDKYDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE 553

  Fly   594 PLSAVDTH---VGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY-ESMA 654
            ..||:||.   |.:...::...|    ...:::.|:|..:..|||||:::.|.::..||: |.|.
 Frog   554 ATSALDTESESVVQDALEKASAG----RTTIVIAHRLSTVWTADVIVVIENGAVAEQGTHKELME 614

  Fly   655 KSGLDFAQMLT-------DPSKKDEGAGDAPDKKSL-SRQNSKLRDRHGSISSMESAAESLAAES 711
            |.|: :..::|       :..|:.|.|.:...|.|| .|.:||:..|...:.. |...|.:..||
 Frog   615 KKGI-YHSLVTAQSIDAAETDKQTETAQEMNRKPSLVKRLSSKISTRSEHLEE-EEEKEDVKEES 677

  Fly   712 PMQTQEGRVEGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDT 776
            ..:....::     :.|.|.           .:.:..||.......|....::.:
 Frog   678 LPKVSFFKI-----LNLNKS-----------EWPYILIGTLAAIINGGAHPAFCI---------- 716

  Fly   777 FMARLRRAF----PETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFF------YLAMRSSTTL 831
            |.|::...|    || ||..:.           |:..|||:::..:.|.      ::..||...|
 Frog   717 FFAKVSAVFSTNDPE-RIQREA-----------NLYSIIFAVIGVISFLTYFLQGFMFGRSGEVL 769

  Fly   832 HNTM------FQGVTRAAMHFFN--TNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIV 888
              ||      |:.:.|..|.:|:  .|.:|.:..|.:.|..|: ::.....:.::...:|.:|:.
 Frog   770 --TMRVRQMAFKAMLRQEMSWFDDKKNSTGALTTRLATDASQI-QMATGSRLGLIAENVACMGLS 831

  Fly   889 VVLCIINVW----YILATVFLVIVFYLLRVFYLS--TSRDVKRLEAVTRSPIYSHLSASLNGLAT 947
            |::..:..|    .|||....:||..||....|:  .:||.|.|:...:.     .:.:::.:.|
 Frog   832 VIIAFVYGWELTLLILAMTPFIIVTGLLETSALTGFANRDKKELQVAGKI-----AAETVDNIRT 891

  Fly   948 I------RAFGAQKELIAE-----FDNYQD-----------MHSSGYYMFLATSRAFGYWLDC-- 988
            :      |||   :|:.||     :.|.|.           ..|..|:.:.||.|..|..|:.
 Frog   892 VISLTRERAF---EEMYAESLQKPYRNSQKRAQVYGICFALSQSFIYFSYAATFRFGGLMLELGR 953

  Fly   989 ----VCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEY 1049
                ..::..|::|..            .:::.|::..          :.:.....:|...:...
 Frog   954 TNSEELILVFAIVTYG------------AMSVGQSLSF----------APDYSKAKSAASHLFAL 996

  Fly  1050 EDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRT 1114
            .:.||..|...:..:||.   ...|.:....:|..| |.:....||:.|:|.|:..:.|..||.:
 Frog   997 FEREPAIDSYCQQGQKPE---TFQGSVELRKVSFNY-PSRPDVPVLQGLSIKIQSGQTVAFVGSS 1057

  Fly  1115 GAGKSSLINALFRLSYN--EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDE 1177
            |.|||:.:..|.|. |:  :|.:|.|..|...|.:..|||:|:|:.||||||..::..|:    .
 Frog  1058 GCGKSTSVQLLQRF-YDPYQGDVLFDNLDAKCLNIQWLRSQIAIVSQEPVLFDCSIAENI----A 1117

  Fly  1178 YSDAKLWESLEEVK-------LKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRIL 1235
            |.|......:||::       :...:..||....:|:...||..|.||:|.:.:|||::|:.::|
 Frog  1118 YGDNSRAVPMEEIQRAAKAANIHSFIEGLPEKYNTKVGGKGTQLSGGQKQRIAIARALVRKPKLL 1182

  Fly  1236 VMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELL 1299
            ::||||:.:|.:::.::|..:....:..|.:.|||||.||.::|.::||..|:.:|.|:..:||
 Frog  1183 LLDEATSALDNESEKIVQQALDQARQGRTCILIAHRLSTVQNADVIVVMKNGRIIELGNHQQLL 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	312/1364 (23%)
		ABC_membrane	98..367	CDD:294371	50/297 (17%)
		ABCC_MRP_domain1	443..643	CDD:213217	72/222 (32%)
		ABC_membrane	799..1027	CDD:294371	54/275 (20%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	74/229 (32%)
LOC100485969	XP_031758323.1	PTZ00265	103..1252	CDD:240339	295/1284 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910