DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and hspa1b

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_002937685.2	Gene:	hspa1b / 100485441	XenbaseID:	XB-GENE-5915622	Length:	643	Species:	Xenopus tropicalis

Alignment Length:	244	Identity:	55/244 - (22%)
Similarity:	91/244 - (37%)	Gaps:	80/244 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1055 EGDFESKPNKKPPKDWPEDGKIVFDDLSLKYF-------------PDKAADYVLRSLNIAIEGCE 1106
            :|.||.|..........||    ||:..:.:|             |:|.|   ||.|..|   ||
Frog   215 DGIFEVKATAGDTHLGGED----FDNRMVNHFVEEFKRKHKKDISPNKRA---LRRLRTA---CE 269

  Fly  1107 KVGIVGRTGAGKSSLINALFRLSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPV---LFSGTM 1168
            :......:....|..|::||     ||.              |..:.|:....|.:   ||.||
Frog   270 RAKRTLSSSTQASIEIDSLF-----EGI--------------DFYTSITRARFEELCADLFRGT- 314

  Fly  1169 RYNLDPFDE-YSDAKLWES-LEEV----------KLKQVVADLPSGLQSKISEGGTNFSVGQRQL 1221
               |:|.:: ..||||.:| :.|:          |:::::.|..:|.:       .|.|:...:.
Frog   315 ---LEPVEKAMRDAKLDKSQIHEIVLVGGSTRIPKVQKLLQDFFNGKE-------LNKSINPDEA 369

  Fly  1222 VCLARAI--------LREN--RILVMDEATANVDPQTDALIQTTI--RN 1258
            |....|:        ..||  .:|::|.|..::..:|...:.|.:  ||
Frog   370 VAYGAAVQAAILMGDKSENVQDLLLLDVAPLSLGLETAGGVMTVLIKRN 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	55/244 (23%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217
		ABC_membrane	799..1027	CDD:294371
		ABCC_MRP_domain2	1074..1295	CDD:213211	49/225 (22%)
hspa1b	XP_002937685.2	PTZ00009	2..643	CDD:240227	55/244 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165170268
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930