Protein Alignment CG4562 and abcc2

DIOPT Version :9

• Sequence 1: NP_001262747.1
• Gene: CG4562 / 42362
• FlyBaseID: FBgn0038740
• Length: 1408
• Species: Drosophila melanogaster
• Sequence 2: XP_004915926.1
• Gene: abcc2 / 100485020
• XenbaseID: XB-GENE-1012796
• Length: 1552
• Species: Xenopus tropicalis
• Alignment Length: 1441
• Identity: 499/1441 - (34%)
• Similarity: 782/1441 - (54%)
• Gaps: 201/1441 - (13%)

  Fly     3 SMKADELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRS-----------DH 56
            |.|.:...|||...::..|.:.|.:......||.||.|:..||:...:|.::           .|
 Frog   193 SEKNESTKENPELTASFLSRITFNWYNSIVVKGYKKPLEMEDLWELNEEDKTKNMYEIFEKHMKH 257

  Fly    57 LGSKLSAAWEK----------------------------EVEKKRKKKKTPS------------L 81
            ...|.....||                            |.:||.||||..|            |
 Frog   258 DVRKAKKDLEKRKNKRKQKESGIEMNGISKAQSQDILVMEEKKKEKKKKEKSIDGTAKDYPKRWL 322

  Fly    82 LKASMNVFGWRLAGLGLVLFILEIGFRVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILT 146
            :|..:..|...|....:...:.:: .....|..|..:|.:.||.|    .:|.:.:.||:.:::|
 Frog   323 IKTLIKTFPSTLLTSAIFKLLHDL-LAFVSPQILKVMVTFTADPS----QHQWQGFFYAVLLLVT 382

  Fly   147 SACNVLFMHPYMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGR-LDV- 209
            :......:..|..|.|.:||:.|..:.:.:|:|||.:|.....::|:|:.|||:|.|..| :|:
 Frog   383 ALLQSFLLQQYFHGCFVLGMRVRSLLMAAVYKKALTVSNAIRKESTVGETVNLMSADAQRFMDLT 447

  Fly   210 SVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDER 274
            :.||:  ||..|::|.|....::.|:|.|...|:.||:|.||:.|.|...:..|::|.....|:|
 Frog   448 NFIHL--LWSSPLQIAISIVFLWEELGPSVLAGLGVMILLIPINAVLATVSRKLQMKNMKNKDKR 510

  Fly   275 VRMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRG------TLQSFIMFVTRIS 333
            :::||||::||:::|:||||..|...:..:|.||:..:.:..|:..      |...|::.|...:
 Frog   511 MKIMNEILNGIKILKLYAWEPSFENQVQEIREKELKDMLHFTYLHSVSLFVFTCAPFLVSVATFA 575

  Fly   334 VFVSLVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETK 398
            |:|:    |....:|.|||||...:.:||||..:.: .||.||...:..||..|::.:
 Frog   576 VYVA----VDPSNVLNAEKAFTSISLFNILRFPLAM-LPMLISSMVQTSVSSARLEKY------- 628

  Fly   399 VRDKSEDLDEQKLGKAGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDN 463
                   |....|..:.:..:|.:                 :.::..|.....|:: :.:..::|
 Frog   629 -------LGGDNLDTSAIRCDPNI-----------------DAAVQFSDATFSWEE-DANPAVNN 668

  Fly   464 ISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILF 528
            ::|..|...||||:|.||||||||:.|:|||::...|.:.:.|:::|..|:.|:...|::.||||
 Frog   669 VNLDIKEGNLVAVVGGVGSGKSSLVSAMLGEMDHVGGYINIKGSIAYVPQQAWIQNATLKNNILF 733

  Fly   529 GLPMDKHRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDD 593
            |..||:.||:.|::.|||..|.|:||..|::.:||:|.:||||||.|:|||||||..||||:|||
 Frog   734 GSKMDEERYQKVLEACALLPDLEMLPGHDESEIGEKGINLSGGQKQRVSLARAVYNDADIYILDD 798

  Fly   594 PLSAVDTHVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKS 656
            ||||||.|||:|:|::.:  .|.|:.:..:||||.:.||:.||.||::...:::..|:|:::..:
 Frog   799 PLSAVDAHVGKHIFEKVVGPNGLLKNKTRILVTHGVSFLKHADDIVVLVNSRVTETGSYKTLQAN 863

  Fly   657 GLDFAQML---------TD------PSKKDEGAGDAPD---------KKSLSRQNSKLRDRHGSI 697
            ...||:.|         ||      ..:.||..||..:         ..::.|:||..:.:..|:
 Frog   864 NGAFAEFLRLYAKQNDQTDNEATVFTGEDDEDDGDQVETAEVIEDIVASTVKRENSMRQRKRSSV 928

  Fly   698 S--------------------SMESAAESLAAESPMQTQEGRVEGRIGMKLYKKYFGANGYGLFI 742
            |                    |.::..:.|..:..::|      |::..|||.||..|.|:|
 Frog   929 SMNGTLRRSVKDVTKKKTGIGSNDTKGQKLIEKETVET------GKVKFKLYLKYLRAVGWG--- 984

  Fly   743 VFAFFCIGAQVLAS----GGDIFLSYWVNKNGEAER---DTFMARLRRAFPETRINADTDPVDIY 800
             |:|:...:.:|.:    |.:|:||.|   .|:||:   .|:.|..|    :.|:..
 Frog   985 -FSFWIFVSYILQNAAFVGQNIWLSDW---TGDAEKYYNITYPASQR----DMRVGV-------- 1033

  Fly   801 YFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQ 865
             |..:.|:..:|.|:.:.|....|:|:|..||..:...:.|..|.||:|.|:|||:|||:||:..
 Frog  1034 -FGALGVAQALFVLLGAFLVSGGAVRASRMLHTQLLHNILRVPMRFFDTTPTGRIVNRFAKDILT 1097

  Fly   866 VDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAVT 930
            |||.:|......:..||.::|.:.::|:....:....|.|.|.:|.::.||::|||.::||::||
 Frog  1098 VDETIPMSFRSWIACFLGVIGTLFIICLATPIFAAVIVPLAIFYYFVQRFYVTTSRQLRRLDSVT 1162

  Fly   931 RSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVCVVYIA 995
            |||||||...:::||:.|||:|.|...:...::..|.:....|.::.::|    || .:.:.::.
 Frog  1163 RSPIYSHFGETVSGLSVIRAYGHQDRFLQHNEDTIDNNQKSVYSWIVSNR----WL-AIRLEFVG 1222

  Fly   996 VITLSF-FLFS-----PENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEP 1054
            .:|:.| .||:     ..:.|.|||:|:.|:.:|..:.|.:|.::|||..:.|||||.||..:|.
 Frog  1223 NLTVFFAALFAVLGRGTVDSGTVGLSISSALNITQTLNWLVRMTSELETNIVAVERVDEYIKVER 1287

  Fly  1055 EGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKS 1119
            |..:..  :.:|||||||.|.:.|.|..::|.|:  .|.||:.::..|...||||||||||||||
 Frog  1288 EAQWVE--DHRPPKDWPEKGVVQFVDYKVRYRPE--LDLVLQGISCTINSMEKVGIVGRTGAGKS 1348

  Fly  1120 SLINALFRLSYNEGA-ILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKL 1183
            ||.|.:||:..:.|. |:||..|...:||||||.|::||||:||||||.:|.|||||::|:|..:
 Frog  1349 SLTNCIFRIIESAGGKIMIDGLDIASIGLHDLRQKLTIIPQDPVLFSGNLRMNLDPFNQYTDEDI 1413

  Fly  1184 WESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQT 1248
            |::||...||..|..|...|..::||||.|.|||||||||||||:||:::||::|||||.||.:|
 Frog  1414 WKALELSHLKPFVEGLQEKLFHEVSEGGENLSVGQRQLVCLARALLRKSKILILDEATAAVDLET 1478

  Fly  1249 DALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQ 1313
            |.|||.|||::|.|||||||||||||:|||.:::|:||||.:|||||.|||  ..:..|.||.|.
 Frog  1479 DNLIQRTIRSEFADCTVLTIAHRLHTIMDSSRLMVLDAGKIIEFGSPDELL--QRQGHFFSMAKD 1541

  Fly  1314 TG-DSTFDALL 1323
            .| |||...:|
 Frog  1542 AGIDSTQSTIL 1552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	486/1406 (35%)
		ABC_membrane	98..367	CDD:294371	84/276 (30%)
		ABCC_MRP_domain1	443..643	CDD:213217	93/201 (46%)
		ABC_membrane	799..1027	CDD:294371	75/233 (32%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	128/221 (58%)
abcc2	XP_004915926.1	MRP_assoc_pro	10..1544	CDD:188098	494/1431 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930