DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc8b

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_021323602.1	Gene:	abcc8b / 100329706	ZFINID:	ZDB-GENE-120215-45	Length:	1607	Species:	Danio rerio

Alignment Length:	1450	Identity:	441/1450 - (30%)
Similarity:	682/1450 - (47%)	Gaps:	245/1450 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ELPENPREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHL-GSKLSAAWEKEVEK 71
            :||::.|..||              |:..:|..|..      .|....|| ||    .|
Zfish   267 KLPKSMRALSN--------------FQQLRKAFDSQ------MESGCVHLQGS----GW------ 301

  Fly    72 KRKKKKTPSLLKASMNVFGWRLAGLGLVLFILEIGFRVTQ-------PLFLGGLVAYYADASNQE 129
                     :.:|....||..|        :|.|.||...       ||.:.|::.:.:
Zfish   302 ---------MWRALRQAFGAPL--------LLSICFRFISDLLGFAGPLCISGILQHIS------ 343

  Fly   130 GDNQTK------------------AYLYALGVILTSACNVLFMHPYMLGMFHI----GMKARIAM 172
            .||.|.                  |..|.|.|:|..|  :|....::...:::    |:..|.|:
Zfish   344 RDNHTAPPPVKLLGVHFISSEVFFANAYVLAVLLFLA--LLLQRTFLQASYYVAIENGINLRGAV 406

  Fly   173 TSMIYRKALRL--SRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREI 235
            .:.||.|.:||  |..::||.|..|:.||::.|..:|.........||..||:|.|...|:|..:
Zfish   407 QTKIYNKIMRLCTSNMSMGDMTTAQICNLVARDTNQLMWFFFLCPNLWAMPVQIVIGVLLLYYLL 471

  Fly   236 GISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKM 300
            |.||..|..|:.:..|||.::..:.|..:..|...|.||::..||::.||:::|:||||..|...
Zfish   472 GASALIGATVITVLAPLQYFVATRLSRAQKSTLEYTSERLKKTNELLRGIKLLKLYAWEHIFRSS 536

  Fly   301 INYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS--------LVGFVLLGKL-------LTA 350
            :...|.:|:.::|          :|.:: |.:|:|::        |..||:...|       |:.
Zfish   537 VEETRRQELTSLR----------TFALY-TSLSIFMNAAIPIAAVLTIFVVHVHLQSSSDFALSP 590

  Fly   351 EKAFVITAYYNILRNTMTVYFPMG--ISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGK 413
            ..||...:.::||   :|..|.:.  :....:.|||::::..|:...|.       :.|:..:.:
Zfish   591 AVAFGSLSLFHIL---VTPLFLLSSVLHSTVKALVSVQKLSEFLSSAEI-------ETDQDPIAQ 645

  Fly   414 AGLIAEPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWD---------------QKNTDN---- 459
                   |.|...|.:|  |....:.:..:|..|.|||.|               .::.||
Zfish   646 -------TPANNNGNIK--SVYALQLQAKLVNRKNKAKQDVNRNFEQQDQELRASAQHEDNICIK 701

  Fly   460 -------------TLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVN------ 505
                         ||.||.:|....||..::|.||||||||:.|.|||:...|||:..|
Zfish   702 IVNGYFSWTQGCPTLTNIDIKVPFGQLTMIVGQVGSGKSSLLLAALGEMQKISGSITWNSLPRSD 766

  Fly   506 -------------------GTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFE 551
                               |:::||||.|||...||.:||||....:..||:.|::.|.|..|.:
Zfish   767 SDENIRAHDMSGRQSFTRRGSVAYASQRPWLLNATVEENILFDTAPNVKRYKDVIEVCQLGPDID 831

  Fly   552 LLPYADKTIVGER----GASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCMR 612
            .||..|:|::|||    |..|||||:.|||:|||:|::.::..||||.||:|.|:..||..:.:.
Zfish   832 TLPQGDQTVIGERVRHLGIILSGGQRQRISVARALYQQTNVVFLDDPFSALDIHLSDHLMHEGIL 896

  Fly   613 GFLREE--IVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESM--AKSGLDFAQMLTDPSKKDEG 673
            .|||:|  .|:||||:||:|..||.|:.|..|.:...||.:.:  |:..| |.|..|..:::|:.
Zfish   897 KFLRQEKRSVVLVTHKLQYLPHADWIIAMRDGTVQTQGTLKDIQCAEPEL-FEQWRTLMNRQDKE 960

  Fly   674 AGDAPDKKSLSRQNSKLRDRHGSISSMESA--AESLAAESPMQTQEG------RVEGRIGMKLYK 730
            ......:||..|.....||...:....|.|  |.|...:|...|.|.      |....|....:.
Zfish   961 NSTELKRKSFRRAMMYSRDTVATDDEDEVADVAVSEVKDSSTSTDEDSLGAELRHRTTIPWSSFA 1025

  Fly   731 KYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNKNGEAERDTFMARLRRAFPETRINADTD 795
            .|..|.|..|..:.....:....|....|.:|::|.:       |...|:...|........|..
Zfish  1026 TYLKAAGLFLLPLLIVSQLAKHSLMVAIDFWLAHWTS-------DVIAAQSESAERNCTFTKDCV 1083

  Fly   796 PVDIYY---FTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTNPSGRILN 857
            ....:|   |..:....|:..||.|:...:..:|.:..||.::.:.:..|.|..|.|.|.|.|||
Zfish  1084 FSHSWYLQVFCLLCALGIVLCLVTSLAVEWTGLRVAKELHCSLLRIIVLAPMRLFETTPLGNILN 1148

  Fly   858 RFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRD 922
            |||.|...:|:.:|..|..:.:..|..|..|.|:..:...:::|.:.|.:..|.::.::...|||
Zfish  1149 RFSTDTNTIDQHIPVTMECLSRSTLLCVSAVGVISYVTPVFLIALLPLTVACYFIQKYFRVASRD 1213

  Fly   923 VKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD 987
            :::||..|..|:.||.|.::.||.|||||..::....:...:.|.::.......|.:|    ||:
Zfish  1214 LQQLEDSTEMPLLSHYSQTIEGLTTIRAFRHEQRFKKKLLEHTDANNISSLFLTAANR----WLE 1274

  Fly   988 -------CVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVER 1045
                   .:.|:..||.:::..|:...:.|.|||.:|.|:.::..:.|.:|..|::|..:..|:|
Zfish  1275 VRMEYIGALVVLIAAVASITNALYRQLSAGLVGLGLTYALMVSNYLNWIVRNLADMEVQLGCVKR 1339

  Fly  1046 VVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGI 1110
            |......:||.........:.|..||:.|:|...:||::|  |.:...||:.::..|...:||||
Zfish  1340 VSGLIHTQPESYDNIMTPAQVPAGWPKYGEIQIQNLSVRY--DSSLKPVLKHVSAHIRPGQKVGI 1402

  Fly  1111 VGRTGAGKSSLINALFRL-SYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNLDP 1174
            .||||:||||...||||: ...||.|.||..|.:.|.|..||||.|||.|:|:|||||:|:||||
Zfish  1403 CGRTGSGKSSFSLALFRMVDTFEGQISIDGIDISKLPLQTLRSKFSIILQDPILFSGTIRFNLDP 1467

  Fly  1175 FDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVMDE 1239
            ..:.:|..|||:||..:|..||..||.||.:.::|||.|||.|||||.|||||.:|::.||:|||
Zfish  1468 ERKATDEMLWEALEIAQLMPVVKALPGGLDAVVTEGGENFSQGQRQLFCLARAFVRKSSILIMDE 1532

  Fly  1240 ATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTSEK 1304
            |||::|..|::::|..:...|.|.||:|||||:||::.||.|:||..|..:|:..|..||   |:
Zfish  1533 ATASIDMATESILQKVVMTAFADRTVVTIAHRVHTILGSDVVIVMKHGGIIEYDEPDVLL---EQ 1594

  Fly  1305 KVFHSMVKQTGDSTFDALLK 1324
            |          ||.|.|.::
Zfish  1595 K----------DSVFSAFVR 1604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	432/1420 (30%)
		ABC_membrane	98..367	CDD:294371	81/314 (26%)
		ABCC_MRP_domain1	443..643	CDD:213217	98/262 (37%)
		ABC_membrane	799..1027	CDD:294371	64/237 (27%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	111/221 (50%)
abcc8b	XP_021323602.1	SunT	239..1600	CDD:331423	439/1444 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586040
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.650