DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4562 and selenoo

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001135537.3	Gene:	selenoo / 100216080	XenbaseID:	XB-GENE-981299	Length:	681	Species:	Xenopus tropicalis

Alignment Length:	740	Identity:	132/740 - (17%)
Similarity:	230/740 - (31%)	Gaps:	296/740 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   635 VIVIMDKGKISAMGT-YESMAKSGLDFAQMLTDPSKKDEGAGDAPDKKSLSRQN------SKLRD 692
            ::.||.:|.:||.|| :.::....|....:..:|       ||..::::.:.:.      |::|.
Frog    38 ILAIMSRGILSAPGTGFHALTFDNLALRSLPVEP-------GDGTEEEARTPRQVPGACFSRVRP 95

  Fly   693 R---HGSISSMESAAESLAAESPMQTQEGRVEGRIGMKLYKK-------YFGANGYGLFIVFAFF 747
            .   :.::.::..:|.||......:..|...|...|.:|...       |.| :.:|.|
Frog    96 TPLLNPTVVALSRSALSLLGLQVGEEDEEATEYFSGNRLLPGSEPAAHCYCG-HQFGNF------ 153

  Fly   748 CIGAQVLASGGDIFLSYWVNKNG-----------------EAE-RDTFMARLRR----------A 784
               |..|..|..::|...||..|                 :|: |....:.:|.          .
Frog   154 ---AGQLGDGAAMYLGEVVNATGKRWEIQLKGAGLTPYSRQADGRKVLRSSIREFLCSEAMSHLG 215

  Fly   785 FPETR----INADTDPV-DIYY---------------------------------FTG------- 804
            .|.||    :.||:..: ||||                                 |||
Frog   216 IPSTRAGSCVTADSTVIRDIYYDGNPKKEKCTVVSRIAPTFLRFGSFEIFKPTDEFTGRKGPSVD 280

  Fly   805 ---INVSVIIFSLVRSMLFFYLAMRSSTTLHNT-----MFQGVTRAAMHF-------------FN 848
               |.:.::.: ::|:   ||..::.....:||     .|:.:|:.....             .|
Frog   281 RNDIRIQMLDY-VIRT---FYPDIQEKHAGNNTEKNAAFFREITKRTARLVAEWQCVGFCHGVLN 341

  Fly   849 TN------------PSGRI--------------LNRFSK---------DLGQVDE-ILPSVMMDV 877
            |:            |.|.|              :.|::.         :||::.| ::|.:.:.:
Frog   342 TDNMSIVGLTIDYGPFGFIDRYDPEYICNGSDNMGRYAYNKQPEICKWNLGKLAEALIPELPLSI 406

  Fly   878 MQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVFYLSTSRDVKRLEAV-TRSPIYSHLSAS 941
            .|            .|::..|...          .:..|:...|  |:|..| .:....|||.:.
Frog   407 SQ------------SILDDEYDAE----------FQNHYMEKMR--KKLGLVRLKLDDDSHLVSD 447

  Fly   942 LNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSRAFGYWLD-----------CVCVVYIA 995
            |  |.|:...|      ::|.|          .|...|:..|...:           |..|..:.
Frog   448 L--LETMNITG------SDFTN----------TFRVLSKFSGDEAEIQDFLNIIIEQCASVEELK 494

  Fly   996 VI--------TLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDL 1052
            ::        .||..|...::.       .|...|.|      .||    |....:||:.:|..|
Frog   495 LVFKPKMDPRQLSMMLMLAQSN-------PQLFSMIG------TQS----NINKELERIDQYTKL 542

  Fly  1053 -EPEGDFESKPNKKPPKDW--------------PEDGKIVFDDLSLKYFPDKAADYVLRS--LNI 1100
             |...|...|.|||..|:|              .||.| .|.:..:|........|:||:  ...
Frog   543 QETSADDLLKDNKKHWKEWLRKYSVRLEKERGSVEDRK-AFHEEHVKTMDSNNPSYILRNYIAQN 606

  Fly  1101 AIEGCEKVGIVGRTGAGKSSLINALFRLSYN------EGAILIDRRDTNDLGLHDLRSKISIIPQ 1159
            ||:..|         :|..|.:..:.::..|      .|..:.|:....|:.:  ..|.:|..|.
Frog   607 AIDSAE---------SGDFSEVKRVLQMLENPYQEGESGQSIADKSPEEDVAV--AASSVSTNPS 660

  Fly  1160 EPVLFSGTMRYNLDPFDEYSDAKLW 1184
            .       :.||..|       .||
Frog   661 R-------LPYNSKP-------PLW 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	132/740 (18%)
		ABC_membrane	98..367	CDD:294371
		ABCC_MRP_domain1	443..643	CDD:213217	2/7 (29%)
		ABC_membrane	799..1027	CDD:294371	52/344 (15%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	23/119 (19%)
selenoo	NP_001135537.3	UPF0061	54..681	CDD:327565	125/724 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165170308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930