DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcb4

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	NP_001303643.1	Gene:	abcb4 / 100136865	ZFINID:	ZDB-GENE-080204-52	Length:	1275	Species:	Danio rerio

Alignment Length:	1439	Identity:	313/1439 - (21%)
Similarity:	566/1439 - (39%)	Gaps:	360/1439 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 SKLSAAWEKEVE----------KKRKKKKTPSLLKASMNVFGWR------LAGLGLVLFILEIGF 107
            |||..:.:|:.|          |:.|::|....:...:.:|.:.      |..|||::.:.....
Zfish     5 SKLKVSSDKKEENGDVSGEKNGKEEKEEKEKLEMVGPIELFRYADSIDILLMMLGLIMSMANGAV 69

  Fly   108 RVTQPLFLGGLVAYYAD--------------------ASN-QEGDNQTKAYLY--ALG-VILTSA 148
            .....:..|.:...:.|                    .|| ..|:..|...:|  .:| |:|.:|
Zfish    70 LPLMVIVFGDMTDSFVDDTLLDNLKNITLPPNFTFPETSNITLGEKMTTHAIYYSIMGFVVLVAA 134

  Fly   149 CNVLFMHPYMLG---------MFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDV 204
            ...:.......|         .||..||..|....:               ...||:...:::||
Zfish   135 YMQVAFWTLAAGRQVKKLRKIFFHSIMKQEIGWFDV---------------NETGQLNTRLTDDV 184

  Fly   205 GRLDVSVIHMNYLWLGPVEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVL-RLKTA 268
            .:::..:...    ||.:...:.|:::...||.:.  |..:.|:.:.:...||...:|: ::.|.
Zfish   185 YKINEGIGDK----LGMLIQNLTTFIVGIIIGFAK--GWKLTLVILAVSPLLGISAAVIGKVMTT 243

  Fly   269 LRTDERV------RMMNEIISGIQVIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIM 327
            ..:.|:.      .:..|::|.|:.:..:..:....|..:    |.:...:||...:....:..|
Zfish   244 FTSKEQTAYAKAGAVAEEVLSSIRTVFAFGGQKKEIKRYH----KNLEDAKNVGVRKAITVNIAM 304

  Fly   328 FVTRISVFVS------------LVGFVLLGKLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAE 380
            ..|...:::|            |.|...:|.|||...|.:|.|:              |:.|.:.
Zfish   305 GFTFFMIYMSYALAFWYGSTLILGGEYTIGMLLTIFFAVLIGAF--------------GLGQTSP 355

  Fly   381 LLVSIRRIQTF------------MLHEETKVRDKSED---LDEQKLGKAGLIAEPTVAQTTGVLK 430
                  .||||            ::..|.|:...||:   ||..|
Zfish   356 ------NIQTFSSARGAAHKVFQIIDHEPKINSFSEEGYKLDVVK-------------------- 394

  Fly   431 PSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAVLGEL 495
                      .:|....:..::..::....|:.::||....|.:|::|..|.|||:.||.:....
Zfish   395 ----------GNIEFKNIHFRYPSRDDVKVLNGMNLKVMSGQTIALVGSSGCGKSTTIQLLQRFY 449

  Fly   496 NPDSGSVKVNG-------------TLSYASQEPWLFTGTVRQNILFG-----------LPMDKHR 536
            :|..|||.::|             .:...||||.||..|:.:||.:|           ...:.:.
Zfish   450 DPQEGSVSIDGHDIRSLNVRGLRELIGVVSQEPVLFATTIAENIRYGRQDVTQDEIEQAAREANA 514

  Fly   537 YRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTH 601
            |..::|          ||...:|:||:||..:|||||.||::|||:.|...|.|||:..||:|..
Zfish   515 YNFIMK----------LPDKFETLVGDRGTQMSGGQKQRIAIARALVRNPKILLLDEATSALDAE 569

  Fly   602 ---VGRHLFDQCMRGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTY-ESMAKSGLDFAQ 662
               :.:...|:...|    ...::|.|:|..:..||||.....|:|..:||: |.|.:.|:..:.
Zfish   570 SETIVQAALDKVRLG----RTTIVVAHRLSTIRNADVIAGFQNGEIVELGTHDELMERKGIYHSL 630

  Fly   663 MLTDPSKKDEGAGDAPDKKSLSRQNSKLRDRHGSISSM----------ESAAESLAAESPMQTQE 717
            :.....|..|.|.:..::.::.       ::..|:|||          .|.:|....|....|:|
Zfish   631 VNMQMFKSTEVAEEDSEEMTMD-------EKSPSVSSMNERTLFRQKSRSGSEKELKEEEKPTEE 688

  Fly   718 GRVEGRIGMKLYKKYFGANGYGLFIVF----------AFFCIGAQVLASGGDIFLSYWVNKNGEA 772
            .:|.....:.:.|..:....|.:..:.          ||..|.::::|    :|          |
Zfish   689 EKVPNVSFLTVLKLNYPEWPYMVVGILCATINGGMQPAFAVIFSKIIA----VF----------A 739

  Fly   773 ERDTFMARLRRAFPETRINADTDPVDIY--YFTGINVSVIIFSLVRSMLFF-----YLAMRSSTT 830
            |.|..:.|.|              .|:|  .|.||.| :..|:|......|     .|.||
Zfish   740 EPDQNLVRQR--------------CDLYSLLFAGIGV-LSFFTLFLQGFCFGKAGELLTMR---- 785

  Fly   831 LHNTMFQGVTRAAMHFFN--TNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCI 893
            |....|..:.|..:.:::  .|..|.:..|.:.|..|| :....|.:..:...:|.:|..:|:..
Zfish   786 LRFKAFNAMMRQDLAWYDDTKNSVGALTTRLAADTAQV-QGATGVRLATLAQNVANLGTAIVISF 849

  Fly   894 INVW----YILATVFLVIVFYLLRVFYLS--TSRDVKRLE-----------------AVTRSPIY 935
            :..|    .||:.|.::.|...:::..|:  ..:|.|.||                 ::||...:
Zfish   850 VYGWQLTLLILSIVPIMAVAGAIQMKLLAGHALKDKKELEQAGKIATEAIENVRTVVSLTRESKF 914

  Fly   936 SHLSASLNGLATIRAFGAQKELIAEFDN-YQDMHSSG---------YYMFLATSRAFGYWL---- 986
            ..|              .::.||..:.| .:..|..|         .|...|....||.||
Zfish   915 ESL--------------YEENLIVPYKNAKKKAHVFGLTFSFSQAMIYFAYAGCFKFGSWLIEQK 965

  Fly   987 ----DCVCVVYIAVITLSFFLFSPENGGDVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVV 1047
                :.|.:|..||:.             ..:|:.:|...|...   .:......:.:..:.|..
Zfish   966 LMTFEGVFLVISAVVY-------------GAMAVGEANSFTPNY---AKAKMSASHVLMLINRAP 1014

  Fly  1048 EYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVG 1112
            ..::...:||   ||:|       .:|.:.|:.:..|| |.:....||:.|.:.::..:.:.:||
Zfish  1015 AIDNSSEDGD---KPDK-------FEGNVGFEHVYFKY-PSRPDVPVLQGLKLRVKKGQTLALVG 1068

  Fly  1113 RTGAGKSSLINALFRLSYN--EGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRYNL--- 1172
            .:|.|||:.|..|.|. |:  :|.:::|..|...|.:|.|||:|.|:.||||||..::..|:
Zfish  1069 SSGCGKSTTIQLLERF-YDPQQGRVMLDDNDAKQLNIHWLRSQIGIVSQEPVLFDCSLAENIAYG 1132

  Fly  1173 DPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRILVM 1237
            |...|....::.|:.:...:...:.:||...|::..:.||..|.||:|.:.:||||||..::|::
Zfish  1133 DNSREVDQEEIVEAAKAANIHSFIENLPQRYQTQAGDKGTQLSGGQKQRIAIARAILRNPKVLLL 1197

  Fly  1238 DEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLTTS 1302
            ||||:.:|.:::.::|..:....|..|.:.:||||.|:.::|.:.|:..|..||.|:..:||  |
Zfish  1198 DEATSALDTESEKIVQDALDKASKGRTCIIVAHRLSTIQNADCIAVVQNGVVVEQGTHQQLL--S 1260

  Fly  1303 EKKVFHSMV 1311
            ::..::::|
Zfish  1261 QQGAYYTLV 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	310/1426 (22%)
		ABC_membrane	98..367	CDD:294371	53/320 (17%)
		ABCC_MRP_domain1	443..643	CDD:213217	64/226 (28%)
		ABC_membrane	799..1027	CDD:294371	55/277 (20%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	73/225 (32%)
abcb4	NP_001303643.1	PTZ00265	55..1266	CDD:240339	303/1384 (22%)
		ABC_membrane	60..348	CDD:279056	52/312 (17%)
		ABC_MTABC3_MDL1_MDL2	397..634	CDD:213216	71/250 (28%)
		ABC_membrane	714..984	CDD:279056	63/330 (19%)
		ABC_MTABC3_MDL1_MDL2	1035..1272	CDD:213216	76/239 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000