DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4562 and abcc6b.2

DIOPT Version :9

Sequence 1:	NP_001262747.1	Gene:	CG4562 / 42362	FlyBaseID:	FBgn0038740	Length:	1408	Species:	Drosophila melanogaster
Sequence 2:	XP_003198194.2	Gene:	abcc6b.2 / 100002917	ZFINID:	ZDB-GENE-110208-2	Length:	1502	Species:	Danio rerio

Alignment Length:	1407	Identity:	497/1407 - (35%)
Similarity:	751/1407 - (53%)	Gaps:	193/1407 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ADELPEN----------PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSK 60
            ||:.|:.          |.|.::..|.|:|.:......||.:..|...||:...:|..|:.:...
Zfish   190 ADQRPDTLKPVYVKNPCPVEDASFLSKLLFWWYGRLVVKGYRSPLKAEDLWSLREEDTSEKIICD 254

  Fly    61 LSAAWEKEVEKKRKKKKTPSLLKASMNVFGWRLAG--------------LGLVLFILEIGFRVTQ 111
            |...|.|:..|.::||.  ||.:|  ...|::|:.              .|.|||  ....::..
Zfish   255 LEKEWAKQWAKLQQKKS--SLNEA--QTLGFKLSSCVKQLFRKLFKEQCTGFVLF--RTLAKIFS 313

  Fly   112 PLFLGG--------------------LVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHP 156
            |.||.|                    |:.|..|    |.....|.||:|..:.|.|....||.|.
Zfish   314 PYFLTGTLFLVIQDALMFSIPQVLSLLLGYVRD----EDAPLWKGYLFAFSLFLLSCLQSLFNHQ 374

  Fly   157 YMLGMFHIGMKARIAMTSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGP 221
            ||.....:||:.:.|:..::|||:|.::..|....|:|::|||:|.|..:|...|::.|.|||.|
Zfish   375 YMYTCLTVGMRVKTAVMGLVYRKSLVINSAARKTCTVGEIVNLVSADTQKLVDFVMYFNALWLAP 439

  Fly   222 VEIGIITYLMYREIGISAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQ 286
            :||.:..:.:::.:|.|...|:..::|..||..::.|..|.|:.......|||:::||||:|||:
Zfish   440 IEIALCLFFLWQHLGPSTLAGITTVILIFPLNGFIAKMRSKLQEVQMKHKDERIKLMNEILSGIK 504

  Fly   287 VIKMYAWEIPFSKMINYVRTKEMNAIRNVNYIRGTLQSFIMFVTRISVFVS---LVGFVLLG--- 345
            ::|.||||..|.:.:...|.||:||::         :|.|::...|:.|.|   |:.|.:.|
Zfish   505 ILKFYAWEKAFRERVLGYREKELNALK---------KSQILYSVSIASFNSSTLLIAFAMFGVYV 560

  Fly   346 -----KLLTAEKAFVITAYYNILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSED 405
                 .:|.|:|.||..|..|||:..:: ..|:.:|...:::||::|:.||:            |
Zfish   561 LIDDKHVLDAQKIFVSMALINILKAPLS-QLPIAMSTTMQVVVSLKRLGTFL------------D 612

  Fly   406 LDEQKLGKAGLIA-EPTVAQTTGVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFK 469
            .||.||.....:. .|.:                  .|:||:.....|.:.:|. .|..|::|.:
Zfish   613 QDELKLDSVQRVPYNPNI------------------ESVVINNGTFSWSKDSTP-CLRRINVKVQ 658

  Fly   470 PRQLVAVIGPVGSGKSSLIQAVLGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDK 534
            ...||||:|.||||||||:.|:|||:...||.:.:.|::.|..|:.|:...|::.|||||.....
Zfish   659 RGSLVAVVGHVGSGKSSLLSAMLGEMEKKSGHITITGSVGYVPQQAWIQNATLKDNILFGCEKKD 723

  Fly   535 HRYRTVVKRCALERDFELLPYADKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVD 599
            ..|:.|::.|||..|.|:||..|.|.:||:|.:||||||.|:||||||||.:|||||||||||||
Zfish   724 SLYQKVLEACALLPDLEILPARDATEIGEKGLNLSGGQKQRVSLARAVYRNSDIYLLDDPLSAVD 788

  Fly   600 THVGRHLFDQCM--RGFLREEIVLLVTHQLQFLEQADVIVIMDKGKISAMGTYESMAKSGLDFAQ 662
            .|||:|:|::.:  .|.|:.:..:||||.|.||.|||:|::|..|:|..||:|..:......||:
Zfish   789 AHVGQHIFEKVIGPNGSLKNKTRVLVTHGLSFLPQADLILVMADGEIKEMGSYAELLSRKNAFAE 853

  Fly   663 MLT-DPSKKDEGAGDAPDKKSLSRQNSK------LRDRHG--SISSMESAAESLAAESPMQTQE- 717
            :.. ..|::.|.|.....:||:|..:.|      :|...|  ||.:||      |...|...|:
Zfish   854 LKAFSVSERKESATLKGTRKSVSFLSIKDFSTDLIRGDLGSASIQTME------AISDPKLNQDR 912

  Fly   718 ---GRV-------EGRIGMKLYKKYFGANGYGLFIVFAFFCIGAQVLASGGDIFLSYWVNK---N 769
               ||:       .||:.:::|.:||...|....|...|.....||.:...:.:||.|.:.   |
Zfish   913 DEVGRLTQADKAHTGRVKLEMYVEYFRTIGLAFIIPIIFLYAFQQVASLAYNYWLSLWADDPVIN 977

  Fly   770 GEAERDTFMARLRRAFPETRINADTDPVDIYYFTGINVSVIIF-SLVRSMLFFYLAMRSSTTLHN 833
            |                 |::|.|. .:.:|...|....:.|| :.|...|...:|.|.   ||.
Zfish   978 G-----------------TQVNTDL-KLGVYGALGFAQGIAIFGTTVAISLGGIIASRQ---LHL 1021

  Fly   834 TMFQGVTRAAMHFFNTNPSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWY 898
            .:...|..:.|.||.:.|||.:||||||::..:|.::|    ..::|.|..|..::.:|||   .
Zfish  1022 DLLNNVLHSPMSFFESTPSGNLLNRFSKEIDAIDCMIP----HGLKIMLGYVFKLLEVCII---V 1079

  Fly   899 ILATVF-------LVIVFYLLRVFYLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKE 956
            ::||.|       |.:::..::.||::||..::|||:|:|||||:|.:.::.|.:.|||||.|..
Zfish  1080 LMATPFAGVIILPLTLLYAFIQSFYVATSCQLRRLESVSRSPIYTHFNETVQGASVIRAFGEQPR 1144

  Fly   957 LIAEFDNYQDMHSSGYYMFLATSRAFGYWLDCVC-----VVYIAVITLSFFLFSPENGGDVGLAI 1016
            .|.:.:...|::.:.|:.....||    ||....     ::.:|...||....:..:.|.||||:
Zfish  1145 FILQANCRVDLNQTSYFPRFVASR----WLAVNLEFLGNLLVLAAAILSVMGRATLSPGTVGLAV 1205

  Fly  1017 TQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDLEPEG--DFESKPNKKPPKDWPEDGKIVFD 1079
            :.::.:||::.|.:|...::||.:.:||||.||.:...|.  .||..|   .|.|||..|.|.|.
Zfish  1206 SHSLQVTGILSWIVRSWTDVENNIVSVERVKEYAETAKEAPWTFEDSP---LPSDWPRSGSIGFQ 1267

  Fly  1080 DLSLKYFPDKAADYVLRSLNIAIEGCEKVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTN 1143
            ...|:|  .|..|:.|:.:::::...||||||||||||||||...:|| |...:|.|.||..:..
Zfish  1268 AYGLQY--RKGLDWALKEISLSVNEREKVGIVGRTGAGKSSLALGIFRILEAAKGKIFIDGINIA 1330

  Fly  1144 DLGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKIS 1208
            ::|||:|||:|:||||:||||||::|.||||||.|:|.::|.|||...||..|:|||..|..:.|
Zfish  1331 EIGLHELRSRITIIPQDPVLFSGSLRINLDPFDRYTDEEVWRSLELAHLKTFVSDLPDKLNHECS 1395

  Fly  1209 EGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLH 1273
            |||.|.|:|||||:|||||:||:.:|||:|||||.||.:||.|||:|||.:|:|||||||||||:
Zfish  1396 EGGENLSLGQRQLICLARALLRKTKILVLDEATAAVDLKTDNLIQSTIRTQFEDCTVLTIAHRLN 1460

  Fly  1274 TVMDSDKVLVMDAGKAVEFGSPFELLTTSEKKVFHSMVKQTG 1315
            |:||..:|:|||.|...|..||..|:  |:...|:.|.::.|
Zfish  1461 TIMDYTRVIVMDRGNITEIDSPSNLI--SQHGQFYRMCREAG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4562	NP_001262747.1	CFTR_protein	12..1300	CDD:273530	490/1384 (35%)
		ABC_membrane	98..367	CDD:294371	93/299 (31%)
		ABCC_MRP_domain1	443..643	CDD:213217	97/201 (48%)
		ABC_membrane	799..1027	CDD:294371	73/240 (30%)
		ABCC_MRP_domain2	1074..1295	CDD:213211	125/221 (57%)
abcc6b.2	XP_003198194.2	MRP_assoc_pro	5..1501	CDD:188098	497/1407 (35%)
		ABC_membrane	320..587	CDD:294371	86/279 (31%)
		ABCC_MRP_domain1	633..834	CDD:213217	97/201 (48%)
		ABC_membrane	950..1215	CDD:279056	84/296 (28%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760