DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4562 and abcc1

DIOPT Version :9

Sequence 1:NP_001262747.1 Gene:CG4562 / 42362 FlyBaseID:FBgn0038740 Length:1408 Species:Drosophila melanogaster
Sequence 2:XP_001341895.3 Gene:abcc1 / 100002010 ZFINID:ZDB-GENE-050517-15 Length:1518 Species:Danio rerio


Alignment Length:1380 Identity:490/1380 - (35%)
Similarity:749/1380 - (54%) Gaps:149/1380 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 PREKSNIFSSLMFCFAMPTFFKGRKKTLDENDLYRALQEHRSDHLGSKLSAAWEKE-VEKKRKKK 76
            |...::..|.:.|.:......||.|:.|:|.||:....|.:|:.:..:|...|::| |:.||...
Zfish   209 PESGASFLSKITFWWITGLMVKGYKRPLEEKDLWSLNNEDKSERVVPQLVRRWDQECVKVKRPVD 273

  Fly    77 KT----------------------------------PSLLKASMNVFGWRLAGLGLVLFILEIGF 107
            ||                                  |||..|....||.......|...|.:: .
Zfish   274 KTLYSPKRSTRGEKKDGQPVEESEILLAKALQKTGEPSLFFALCRTFGPYFLVSSLYKIIHDV-L 337

  Fly   108 RVTQPLFLGGLVAYYADASNQEGDNQTKAYLYALGVILTSACNVLFMHPYMLGMFHIGMKARIAM 172
            ....|..|..|:.:..|:|..    ....|.|...:.:.:....|.:..|....|..||:.|.|:
Zfish   338 MFVGPEILRLLILFVNDSSAP----TWHGYFYTALLFVCTCLQTLILQKYFHVCFVTGMRLRTAI 398

  Fly   173 TSMIYRKALRLSRTALGDTTIGQVVNLISNDVGRLDVSVIHMNYLWLGPVEIGIITYLMYREIGI 237
            ...:|||||.::..|...:|:|::|||:|.|..|....:.::|.:|..|:::.:..|.:::.:|.
Zfish   399 VGAVYRKALVITNAARRTSTVGEIVNLMSVDAQRFMDLITYINMIWSAPLQVILALYFLWQNLGA 463

  Fly   238 SAFFGVAVMLLFIPLQAYLGKKTSVLRLKTALRTDERVRMMNEIISGIQVIKMYAWEIPFSKMIN 302
            |...|||||:|.:||.|.:..||...::......|.|:::|||:::||:|:|:||||:.|...::
Zfish   464 SVLAGVAVMVLMVPLNAVIAMKTKTYQVAQMKSKDNRIKLMNEVLNGIKVLKLYAWELAFKGKVS 528

  Fly   303 YVRTKEMNAIRNVNYIRGTLQSFIM----FVTRISVFVSLVGFVLL--GKLLTAEKAFVITAYYN 361
            .:|..|:..::.:.|: |.:.:|..    |:..:|.|..   :||:  ..:|.|:||||..|.:|
Zfish   529 AIRESELRVLKKMAYL-GAISTFTWVCAPFLVALSTFAV---YVLVDENNILDAQKAFVSLALFN 589

  Fly   362 ILRNTMTVYFPMGISQFAELLVSIRRIQTFMLHEETKVRDKSEDLDEQKLGKAGLIAEPTVAQTT 426
            |||..:.: .||.||...:..||::|::.|:.|||         ||:..      :..|.::.| 
Zfish   590 ILRFPLNM-LPMVISSMVQASVSMQRLRVFLSHEE---------LDDDN------VERPAISGT- 637

  Fly   427 GVLKPSSRRTSEAEHSIVISKLKAKWDQKNTDNTLDNISLKFKPRQLVAVIGPVGSGKSSLIQAV 491
                |.|.|.::...|         | .|:...||..|::......||||:|.||||||||:.|:
Zfish   638 ----PDSIRIADGAFS---------W-SKDDPPTLKRINVSIPEGALVAVVGHVGSGKSSLLSAL 688

  Fly   492 LGELNPDSGSVKVNGTLSYASQEPWLFTGTVRQNILFGLPMDKHRYRTVVKRCALERDFELLPYA 556
            |||::...|||.:.|:::|..|:.|:...|::.|||||.......|:.||:.|||..|.|:||..
Zfish   689 LGEMHKQEGSVSIKGSVAYVPQQAWIQNATLKDNILFGRETKDSWYQKVVEACALLPDLEILPGG 753

  Fly   557 DKTIVGERGASLSGGQKARISLARAVYRKADIYLLDDPLSAVDTHVGRHLFDQCM--RGFLREEI 619
            |.|.:||:|.:||||||.|:|:|||||....:|||||||||||.|||:|:|::.:  :|.|:...
Zfish   754 DTTEIGEKGVNLSGGQKQRVSVARAVYCNCSVYLLDDPLSAVDAHVGKHIFEKVIGPQGLLQGRT 818

  Fly   620 VLLVTHQLQFLEQADVIVIMDKGKISAMGTY-ESMAKSGLDFAQML-----TDPSKKDEGAGDAP 678
            .:||||.|.||.|||:|::|..|:|:.||:| |.:.:.|. ||:.|     |:..:.:|..|||.
Zfish   819 RVLVTHGLSFLPQADLILVMVDGEITEMGSYTELLGRQGA-FAEFLRTYTNTEQEEGEESLGDAV 882

  Fly   679 DKKSLSRQNSKLRDRHGSIS----------------SMESAAESLAAESPMQTQEGRVE-GRIGM 726
            .:|.|.........|...||                ...:|.::.:||:...|:..:.. ||:.:
Zfish   883 PRKGLENGGPAALLRQSQISLNATGAGKTTQKTEANDDAAATKTKSAEASRLTEADKANTGRVKL 947

  Fly   727 KLYKKYFGANG--YGLFIVFAFFCIGAQVLASGGDIFLSYW----VNKNGEAERDTFMARLRRAF 785
            .::.:|..|.|  ..:|.:|.|||  ..:.:.|.:.:||.|    |..|.:.:|           
Zfish   948 SVFWEYMKAIGLPLSIFSIFLFFC--HHLSSLGSNYWLSLWTDDPVVNNTQPKR----------- 999

  Fly   786 PETRINADTDPVDIYYFTGINVSVIIFSLVRSMLFFYLAMRSSTTLHNTMFQGVTRAAMHFFNTN 850
             |.|:.       :|...||:..:.:|..  |:......:.:|..||.||...|.|:.|.||...
Zfish  1000 -EMRLG-------VYGALGISQGIAVFCY--SVSVSVGGILASRYLHQTMLYNVLRSPMSFFERT 1054

  Fly   851 PSGRILNRFSKDLGQVDEILPSVMMDVMQIFLAIVGIVVVLCIINVWYILATVFLVIVFYLLRVF 915
            |||.::|||:|:...:|.::||::...|.....::|...|:.|......:....|.::::.::.|
Zfish  1055 PSGNLVNRFAKETDTIDSVIPSIIKMFMGSMFNVLGSCAVILIATPLVAIIIPPLGLLYFFVQRF 1119

  Fly   916 YLSTSRDVKRLEAVTRSPIYSHLSASLNGLATIRAFGAQKELIAEFDNYQDMHSSGYYMFLATSR 980
            |:::||.:||||:|:|||:|:|.:.:|.|.:.|||||.|:..|.|.|...|.:...|:..:..:|
Zfish  1120 YVASSRQMKRLESVSRSPVYTHFNETLLGTSVIRAFGEQQRFIKESDGRVDHNQKAYFPSIVANR 1184

  Fly   981 AFGYWLDCV--CVVYIAVITLSFFLFSPEN--GGDVGLAITQAMGMTGMVQWGMRQSAELENTMT 1041
            .....|:.|  |:|..|.:   |.:.:..|  .|.:||:|:.|:.:|..:.|.:|.|:|||..:.
Zfish  1185 WLAVRLEFVGNCIVTFAAL---FAVMARNNLSPGIMGLSISYALQVTASLNWLVRMSSELETNIV 1246

  Fly  1042 AVERVVEYEDLEPEGDFESKPNKKPPKDWPEDGKIVFDDLSLKYFPDKAADYVLRSLNIAIEGCE 1106
            |||||.||.|.|.|.:::.:.:..|| .||..|.|......|:|..|  .:..:..:::.|.|.|
Zfish  1247 AVERVKEYGDTEKEAEWKLENSNLPP-GWPTAGHIEIHKFGLRYRED--LELAICDISVNIAGGE 1308

  Fly  1107 KVGIVGRTGAGKSSLINALFR-LSYNEGAILIDRRDTNDLGLHDLRSKISIIPQEPVLFSGTMRY 1170
            |||||||||||||||...||| :...||.|.||..:..|||||:|||:|:||||:||||||::|.
Zfish  1309 KVGIVGRTGAGKSSLTLGLFRIIEAAEGEIRIDGVNIADLGLHELRSRITIIPQDPVLFSGSLRM 1373

  Fly  1171 NLDPFDEYSDAKLWESLEEVKLKQVVADLPSGLQSKISEGGTNFSVGQRQLVCLARAILRENRIL 1235
            ||||||.|:|.::|.|||...||..|:.||..|..:.||||.|.|:|||||||||||:||:.:||
Zfish  1374 NLDPFDGYTDEEVWRSLELAHLKTFVSGLPDKLNHECSEGGENLSLGQRQLVCLARALLRKTKIL 1438

  Fly  1236 VMDEATANVDPQTDALIQTTIRNKFKDCTVLTIAHRLHTVMDSDKVLVMDAGKAVEFGSPFELLT 1300
            |:|||||.||.:||.|||:|||.:|:|||||||||||:|:||..:|||:|.|:..||.||..|: 
Zfish  1439 VLDEATAAVDLETDNLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVLVLDKGQMAEFDSPSNLI- 1502

  Fly  1301 TSEKKVFHSMVKQTG 1315
             ::|.:|:.|.|.:|
Zfish  1503 -AKKGIFYKMAKDSG 1516

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4562NP_001262747.1 CFTR_protein 12..1300 CDD:273530 485/1363 (36%)
ABC_membrane 98..367 CDD:294371 82/274 (30%)
ABCC_MRP_domain1 443..643 CDD:213217 93/201 (46%)
ABC_membrane 799..1027 CDD:294371 71/231 (31%)
ABCC_MRP_domain2 1074..1295 CDD:213211 128/221 (58%)
abcc1XP_001341895.3 MRP_assoc_pro 7..1517 CDD:188098 490/1380 (36%)
ABC_membrane 331..595 CDD:279056 81/272 (30%)
ABCC_MRP_domain1 641..842 CDD:213217 95/210 (45%)
ABC_membrane 966..1231 CDD:279056 84/290 (29%)
ABCC_MRP_domain2 1278..1498 CDD:213211 128/221 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170585970
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.760

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