DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4572 and PRC1

DIOPT Version :9

Sequence 1:	NP_650836.1	Gene:	CG4572 / 42360	FlyBaseID:	FBgn0038738	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_014026.1	Gene:	PRC1 / 855343	SGDID:	S000004912	Length:	532	Species:	Saccharomyces cerevisiae

Alignment Length:	430	Identity:	121/430 - (28%)
Similarity:	190/430 - (44%)	Gaps:	61/430 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 VESYSGYLTVDPGFKSNMFFWYFPAEQEPEYAPVVLWLQGGPGASSLFGLFTENGPLELDGHGKL 148
            |..|:|||.|:...| :.|||.|.:..:|...||:|||.||||.|||.|||.|.||..:....|.
Yeast   125 VTQYTGYLDVEDEDK-HFFFWTFESRNDPAKDPVILWLNGGPGCSSLTGLFFELGPSSIGPDLKP 188

  Fly   149 QKRNYTWSKTHNLIYIDNPVGTGFSFTENDAGYATNEKDVGRNLHEAVMQLYELF-EWSN-SSGF 211
            ....|:|:....:|::|.||..|||::.:..  .:|....|::::..:...::.| |:.| ...|
Yeast   189 IGNPYSWNSNATVIFLDQPVNVGFSYSGSSG--VSNTVAAGKDVYNFLELFFDQFPEYVNKGQDF 251

  Fly   212 WVTGESYAGKYVPALAYHI--HKVQNAIETRVYVPLKGVAIGNGLSDPLHQLKYGDYLYQLGLID 274
            .:.||||||.|:|..|..|  ||.:|       ..|..|.|||||:|||.|..|    |:.....
Yeast   252 HIAGESYAGHYIPVFASEILSHKDRN-------FNLTSVLIGNGLTDPLTQYNY----YEPMACG 305

  Fly   275 EHGLQSFHDAEAKGAECIKSHD-MECAFDVFDSLING----DLTNGSLFSN--------LTGYNW 326
            |.|..|...:|    ||....| :|....:.:|..:.    .....:::.|        .||.|
Yeast   306 EGGEPSVLPSE----ECSAMEDSLERCLGLIESCYDSQSVWSCVPATIYCNNAQLAPYQRTGRN- 365

  Fly   327 YYNYLKTHDDDGANL--------GEFLQAGATRRAIHVGNKTFHDLDKENKVELHLKKDIM---D 380
            .|:..|  |.:|.||        .::|.....:.|:..      ::|........:.::.:   |
Yeast   366 VYDIRK--DCEGGNLCYPTLQDIDDYLNQDYVKEAVGA------EVDHYESCNFDINRNFLFAGD 422

  Fly   381 SVAPW---IAELL-AHYTVCIYSGQLDIIVAYPLTRNYLNQLKFPGSDKYKVAPREVW--RVGKE 439
            .:.|:   :.:|| ....:.:|:|..|.|..:...:.:.:.|.:...:::.......|  .:..|
Yeast   423 WMKPYHTAVTDLLNQDLPILVYAGDKDFICNWLGNKAWTDVLPWKYDEEFASQKVRNWTASITDE 487

  Fly   440 VAGYVKHAGHLVEIMVRNAGHMAPHDQPKWLYMMIDHLTH 479
            |||.||...|...:.|.|.|||.|.|.|:....|::...|
Yeast   488 VAGEVKSYKHFTYLRVFNGGHMVPFDVPENALSMVNEWIH 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4572	NP_650836.1	Peptidase_S10	83..479	CDD:298660	120/428 (28%)
PRC1	NP_014026.1	Kex1	25..528	CDD:225490	121/430 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I1064
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I1200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9182
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	1	1.000	-	-		X1443
TreeFam	0	0.000	Not matched by this tool.
	9	8.800