DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4572 and Cpvl

DIOPT Version :9

Sequence 1:	NP_650836.1	Gene:	CG4572 / 42360	FlyBaseID:	FBgn0038738	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_006506676.1	Gene:	Cpvl / 71287	MGIID:	1918537	Length:	484	Species:	Mus musculus

Alignment Length:	439	Identity:	197/439 - (44%)
Similarity:	289/439 - (65%)	Gaps:	17/439 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 DPGEPLFLTPLINNASMSKQEVQKLARVVGSQFHGV--ESYSGYLTVDPGFKSNMFFWYFPAEQE 111
            |.|:||||:|.|.|..:  :|.|:.:.|  |.|.|:  :||:||:||:..:.||:|||:|||..:
Mouse    46 DAGQPLFLSPYIKNGKI--KEGQRKSMV--SPFPGMNDKSYAGYITVNQTYNSNLFFWFFPARMQ 106

  Fly   112 PEYAPVVLWLQGGPGASSLFGLFTENGPLELDGHGKLQKRNYTWSKTHNLIYIDNPVGTGFSFTE 176
            ||.||||||||||||.||:||||.|:||..:..:..:..|::.|:.|.:::|||||||||||||:
Mouse   107 PEDAPVVLWLQGGPGGSSMFGLFVEHGPYIITSNMTVVARDFPWTFTLSMLYIDNPVGTGFSFTD 171

  Fly   177 NDAGYATNEKDVGRNLHEAVMQLYELFEWSNSSGFWVTGESYAGKYVPALAYHIHKVQNAIETRV 241
            :..||||:|.||.::|:.|::|.:.||.....:.|:|||||||||||||||::||.: |.:. :.
Mouse   172 HFQGYATSEDDVAQDLYSALIQFFTLFPEYAKNDFYVTGESYAGKYVPALAHYIHSL-NPVR-KF 234

  Fly   242 YVPLKGVAIGNGLSDPLHQL-KYGDYLYQLGLIDEHGLQSFHDAEAKGAECIKSHDMECAFDVFD 305
            .:.|||:|||:..:||...: .|..:||::||:||...:.|....:|..:.||..:...||::.|
Mouse   235 KIRLKGIAIGDAYTDPESIIGGYAAFLYEIGLLDEQQQKYFQKQCSKCVKYIKEQEWMKAFEILD 299

  Fly   306 SLINGDLTNG-SLFSNLTGYNWYYNYLK-THDDDGANLGEFLQAGATRRAIHVGNKTFHDLDKEN 368
            .|::||:|.| |.|.|:||...|||.|: |...:.:...:||.....|:||||||:.|.|   ..
Mouse   300 KLLDGDVTTGSSFFQNVTGCTNYYNILQCTEPKEQSYFAKFLTLPQVRQAIHVGNQNFSD---GA 361

  Fly   369 KVELHLKKDIMDSVAPWIAELLAHYTVCIYSGQLDIIVAYPLTRNYLNQLKFPGSDKYKVAPREV 433
            :||.||::|.:.||.||::|::.:|.|.||:||||||||..||...|..:.:.||..|:.|.|:|
Mouse   362 EVEKHLREDTVKSVKPWLSEIMNYYKVLIYNGQLDIIVAAALTERSLMAMDWKGSRAYRRARRKV 426

  Fly   434 WRVGK---EVAGYVKHAGHLVEIMVRNAGHMAPHDQPKWLYMMIDHLTH 479
            |::.|   ||||||:..|...:::||..||:.|:|||...:.||:...:
Mouse   427 WKIFKSDNEVAGYVRRVGKFHQVIVRGGGHILPYDQPMRSFDMINRFIY 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4572	NP_650836.1	Peptidase_S10	83..479	CDD:298660	183/403 (45%)
Cpvl	XP_006506676.1	Peptidase_S10	78..474	CDD:366108	182/400 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831202
Domainoid	1	1.000	349	1.000	Domainoid score	I1021
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80235
Inparanoid	1	1.050	365	1.000	Inparanoid score	I2149
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003752
OrthoInspector	1	1.000	-	-		oto92998
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	1	1.100	-	-	LDO	PTHR11802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	1	1.000	-	-		X1443
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790