DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4572 and SCPEP1

DIOPT Version :9

Sequence 1:	NP_650836.1	Gene:	CG4572 / 42360	FlyBaseID:	FBgn0038738	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_067639.1	Gene:	SCPEP1 / 59342	HGNCID:	29507	Length:	452	Species:	Homo sapiens

Alignment Length:	496	Identity:	131/496 - (26%)
Similarity:	205/496 - (41%)	Gaps:	116/496 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ERPYRRSFINPYPRYQFFDDGVDPGEPLFLTPL---INNASMSKQEVQKLARVVGSQFHGVESYS 88
            |...|||   |.||:            |.|.||   :|..::.....::          |.|.:.
Human     2 ELALRRS---PVPRW------------LLLLPLLLGLNAGAVIDWPTEE----------GKEVWD 41

  Fly    89 GYLTVDPGFKSNMFFW-YFPAEQEPEYA--PVVLWLQGGPGASSL-FGLFTENGPLELDGHGKLQ 149
             |:||..  .:.||:| |:.......::  |:|:|||||||.||. ||.|.|.|||:.|    |:
Human    42 -YVTVRK--DAYMFWWLYYATNSCKNFSELPLVMWLQGGPGGSSTGFGNFEEIGPLDSD----LK 99

  Fly   150 KRNYTWSKTHNLIYIDNPVGTGFSFTENDAGYATNEKDVGRNLHEAVMQLYELFEWSNSSGFWVT 214
            .|..||.:..:|:::|||||||||:......||.:...|..::...:...:...:...:..|::.
Human   100 PRKTTWLQAASLLFVDNPVGTGFSYVNGSGAYAKDLAMVASDMMVLLKTFFSCHKEFQTVPFYIF 164

  Fly   215 GESYAGKYVPALAYHIHKVQNAIET-RVYVPLKGVAIGNGLSDPLHQ-LKYGDYLYQLGLIDEHG 277
            .|||.||....:...::|   ||:. .:.....|||:|:....|:.. |.:|.|||.:.|:::.|
Human   165 SESYGGKMAAGIGLELYK---AIQRGTIKCNFAGVALGDSWISPVDSVLSWGPYLYSMSLLEDKG 226

  Fly   278 LQSFHDAEAKGAECIKSHDMECAFDVFDSLINGDLTNGSLF---------------SNLTGYNWY 327
            |          ||..|         |.:.::|.  .|..|:               .|..|.| :
Human   227 L----------AEVSK---------VAEQVLNA--VNKGLYREATELWGKAEMIIEQNTDGVN-F 269

  Fly   328 YNYL--KTHDDDGANLGEFLQAG----ATRRAIHVGNKTFHDL-------------------DKE 367
            ||.|  .|......:..||.|:.    ..|...|:.......|                   .:.
Human   270 YNILTKSTPTSTMESSLEFTQSHLVCLCQRHVRHLQRDALSQLMNGPIRKKLKIIPEDQSWGGQA 334

  Fly   368 NKVELHLKKDIMDSVAPWIAELL-AHYTVCIYSGQLDIIVAYPLTRNYLNQLKFPGSDKYKVAPR 431
            ..|.:::::|.|..|...:.||| |...|.:|:||||:||.......::.:||:|...|:.   :
Human   335 TNVFVNMEEDFMKPVISIVDELLEAGINVTVYNGQLDLIVDTMGQEAWVRKLKWPELPKFS---Q 396

  Fly   432 EVWRV------GKEVAGYVKHAGHLVEIMVRNAGHMAPHDQ 466
            ..|:.      ..|.:.:||...:|....:..||||.|.||
Human   397 LKWKALYSDPKSLETSAFVKSYKNLAFYWILKAGHMVPSDQ 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4572	NP_650836.1	Peptidase_S10	83..479	CDD:298660	119/437 (27%)
SCPEP1	NP_067639.1	Peptidase_S10	36..446	CDD:306866	119/437 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.860