Protein Alignment CG4572 and CTSA

DIOPT Version :9

• Sequence 1: NP_650836.1
• Gene: CG4572 / 42360
• FlyBaseID: FBgn0038738
• Length: 482
• Species: Drosophila melanogaster
• Sequence 2: NP_001161066.1
• Gene: CTSA / 5476
• HGNCID: 9251
• Length: 481
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 136/507 - (26%)
• Similarity: 230/507 - (45%)
• Gaps: 127/507 - (25%)

  Fly    50 PGE--------------PLFLTPLI----------NNASMSKQEVQKLARVVGSQFHGVESYSGY 90
            |||              ||||..|:          ..|:..:.|:|:|..:  ::......||||
Human     9 PGEQGRGGAEMIRAAPPPLFLLLLLLLLLVSWASRGEAAPDQDEIQRLPGL--AKQPSFRQYSGY 71

  Fly    91 LTVDPGFKSNMFFWYFPAEQEPEYAPVVLWLQGGPGASSLFGLFTENGPLELDGHGKLQKRNYTW 155
            |. ..|.| ::.:|:..::::||.:||||||.||||.|||.||.||:||..:
Human    72 LK-GSGSK-HLHYWFVESQKDPENSPVVLWLNGGPGCSSLDGLLTEHGPFLI------------- 121

  Fly   156 SKTHNLIYIDNPVGTGFSFTENDAGYATNEKDVGRNLHEAVMQLYELF-EWSNSSGFWVTGESYA 219
               .|::|:::|.|.|||::: |..||||:.:|.::..||:...:.|| |:.|:..| :||||||
Human   122 ---ANVLYLESPAGVGFSYSD-DKFYATNDTEVAQSNFEALQDFFRLFPEYKNNKLF-LTGESYA 181

  Fly   220 GKYVPALAYHIHKVQNAIETRVYVPLKGVAIGNGLS-----DPLHQLKYGDYLYQLGLIDEH--- 276
            |.|:|.||..:.:..:       :.|:|:|:|||||     |  :.|.|  :.|..||:...
Human   182 GIYIPTLAVLVMQDPS-------MNLQGLAVGNGLSSYEQND--NSLVY--FAYYHGLLGNRLWS 235

  Fly   277 GLQSFHDAEAKGAECIKSHDMECA-----------------FDVF---------------DSLIN 309
            .||: |...........:.|:||.                 ::::               |:::.
Human   236 SLQT-HCCSQNKCNFYDNKDLECVTNLQEVARIVGNSGLNIYNLYAPCAGGVPSHFRYEKDTVVV 299

  Fly   310 GDLTNGSLFSNL-TGYNWYYNYLKTHD--------DDGANLGEFLQAGATRRAIHVGNKTFHDLD 365
            .||  |::|:.| ....|:...|::.|        .:......:|.....|:|:::..: ....|
Human   300 QDL--GNIFTRLPLKRMWHQALLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQ-LPQWD 361

  Fly   366 KEN-KVELHLKKDIMDSVAPWIAELLA--HYTVCIYSGQLDIIVAYPLTRNYLNQLKFPGSDKYK 427
            ..| .|.|..:: :..|:.....:||:  .|.:.:|:|.:|      :..|::....|..|...|
Human   362 MCNFLVNLQYRR-LYRSMNSQYLKLLSSQKYQILLYNGDVD------MACNFMGDEWFVDSLNQK 419

  Fly   428 V-APREVWRV-----GKEVAGYVKHAGHLVEIMVRNAGHMAPHDQPKWLYMM 473
            : ..|..|.|     |:::||:||...|:..:.::.||||.|.|:|...:.|
Human   420 MEVQRRPWLVKYGDSGEQIAGFVKEFSHIAFLTIKGAGHMVPTDKPLAAFTM 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4572	NP_650836.1	Peptidase_S10	83..479	CDD:298660	124/450 (28%)
CTSA	NP_001161066.1	Peptidase_S10	57..477	CDD:278857	124/459 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2160
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.790