DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4572 and cpvl

DIOPT Version :9

Sequence 1:	NP_650836.1	Gene:	CG4572 / 42360	FlyBaseID:	FBgn0038738	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_954972.1	Gene:	cpvl / 387531	ZFINID:	ZDB-GENE-031219-2	Length:	478	Species:	Danio rerio

Alignment Length:	440	Identity:	207/440 - (47%)
Similarity:	286/440 - (65%)	Gaps:	23/440 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GVDPGEPLFLTPLINNASMSKQEVQKLARVVGSQFHGVESYSGYLTVDPGFKSNMFFWYFPAEQE 111
            |.|||:||.|||.:....:  :|.:||:.|.......|:||||||||:..:.||:|||:|||::.
Zfish    40 GADPGKPLMLTPYLEQGKI--EEAKKLSLVGPLPGANVKSYSGYLTVNKTYNSNLFFWFFPAQER 102

  Fly   112 PEYAPVVLWLQGGPGASSLFGLFTENGPLELDGHGKLQKRNYTWSKTHNLIYIDNPVGTGFSFTE 176
            ||.|||:||||||||.:|:||||.|:||..:..:..|..|::.|:..::::|||||||||:||||
Zfish   103 PETAPVLLWLQGGPGGTSMFGLFVEHGPYFVYKNLTLGYRHFPWTSRYSVLYIDNPVGTGWSFTE 167

  Fly   177 NDAGYATNEKDVGRNLHEAVMQLYELFEWSNSSGFWVTGESYAGKYVPALAYHIHKVQNAIETRV 241
            :|.|:|.|:.||||:|:.|:.|.:::|....|:.|:.||||||||||||:.|:||:  |....:|
Zfish   168 DDRGFAQNQDDVGRDLYSALTQFFQIFREFQSNPFYATGESYAGKYVPAIGYYIHR--NNPSAKV 230

  Fly   242 YVPLKGVAIGNGLSDPLHQL-KYGDYLYQLGLIDEHGLQSFH-----DAEAKGAECIKSHDMECA 300
            .:..||||||:||.||...| .|.|:|||.||:||  ||..|     ||   |.:.|:......|
Zfish   231 KINFKGVAIGDGLCDPELMLGGYADFLYQTGLVDE--LQRQHVKMQTDA---GVKLIQEQRWVEA 290

  Fly   301 FDVFDSLINGDLT-NGSLFSNLTGYNWYYNYLKTHD-DDGANLGEFLQAGATRRAIHVGNKTFHD 363
            |.|||||:||||. ..|.|.|:||...|:||::..: .|......|:.....||:|||||.||:|
Zfish   291 FQVFDSLLNGDLVPYPSYFQNVTGCTNYFNYMQCQEPPDQEYFSSFVTLPEVRRSIHVGNLTFND 355

  Fly   364 LDKENKVELHLKKDIMDSVAPWIAELLAHYTVCIYSGQLDIIVAYPLTRNYLNQLKFPGSDKYKV 428
               .:.||.||.:|:|.|:.||:..|:.:|.|.|||||||:|||.|||..:|..:.:.|:|:||.
Zfish   356 ---GSDVEKHLLQDVMKSIKPWLGVLMENYRVLIYSGQLDVIVAAPLTERFLPTVSWSGADEYKT 417

  Fly   429 APREVWRV---GKEVAGYVKHAGHLVEIMVRNAGHMAPHDQPKWLYMMID 475
            |.|..|:|   ..||||||:......:::||..||:.|:|||:..:.|||
Zfish   418 AERFPWKVQPSDTEVAGYVRQVREFFQVIVRGGGHILPYDQPERSFDMID 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4572	NP_650836.1	Peptidase_S10	83..479	CDD:298660	194/404 (48%)
cpvl	NP_954972.1	Peptidase_S10	68..471	CDD:298660	194/410 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574165
Domainoid	1	1.000	367	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H80235
Inparanoid	1	1.050	385	1.000	Inparanoid score	I1989
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003752
OrthoInspector	1	1.000	-	-		oto41604
orthoMCL	1	0.900	-	-		OOG6_100109
Panther	1	1.100	-	-	LDO	PTHR11802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	1	1.000	-	-		X1443
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800