Protein Alignment Ire1 and IRE1

DIOPT Version :10

• Sequence 1: NP_001097839.1
• Gene: Ire1 / 42358
• FlyBaseID: FBgn0261984
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_011946.1
• Gene: IRE1 / 856478
• SGDID: S000001121
• Length: 1115
• Species: Saccharomyces cerevisiae
• Alignment Length: 1063
• Identity: 286/1063 - (26%)
• Similarity: 453/1063 - (42%)
• Gaps: 280/1063 - (26%)

  Fly    55 LMVFSTLGGGLTAIDPVTSEIRWTIADD--PPIVAEHQENVQVPHF---LPDP-RDGSIYQLGQM 113
            :::.:.:.|||.|:|.....|.|:|..:  .|:: |.||..::..:   :.:| .||:||.....
Yeast   122 ILIAADVEGGLHAVDRRNGHIIWSIEPENFQPLI-EIQEPSRLETYETLIIEPFGDGNIYYFNAH 185

  Fly   114 GSLKKLPYTIPQLVANAPCRSSDGI-------------LYSGKKSDTWYMVDPKTGRREKVMG-- 163
            ..|:|||.:|.|||:.:|......|             :|:|......|.::...|......|
Yeast   186 QGLQKLPLSIRQLVSTSPLHLKTNIVVNDSGKIVEDEKVYTGSMRTIMYTINMLNGEIISAFGPG 250

  Fly   164 -----FGDATVDGKEGEQIG-WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITF--YDYNAVS 220
                 ||..:||....|:|. ......|.:|:|.:.:.::     :.|...:|:|:  :..|.:.
Yeast   251 SKNGYFGSQSVDCSPEEKIKLQECENMIVIGKTIFELGIH-----SYDGASYNVTYSTWQQNVLD 310

  Fly   221 APPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLS-------SPVVAAFLLG--------- 269
            .|..|..       |.:.:|..:...|  .|.|...||.       ||.....::|
Yeast   311 VPLALQN-------TFSKDGMCIAPFR--DKSLLASDLDFRIARWVSPTFPGIIVGLFDVFNDLR 366

  Fly   270 --PDGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKGLYALPSLVDKNTPRIST 332
              .:.|:..||.....|:..:          |.|.|.|:..:..........||||:
Yeast   367 TNENILVPHPFNPGDHESISS----------NKVYLDQTSNLSWFALSSQNFPSLVE-------- 413

  Fly   333 APPIKLLDGPTGDQNSNQETDPRTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQ 397
                   ..|.....|:......:|:.::.|.::|  ::|
Yeast   414 -------SAPISRYASSDRWRVSSIFEDETLFKNA--IMG------------------------- 444

  Fly   398 SLATIHN-YNDGYG-LLANNEK-NAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNS--NK 457
                :|. ||:.|. |..|.|| |:.|...:..|.:::..:|           .|.:.||:  |.
Yeast   445 ----VHQIYNNEYDHLYENYEKTNSLDTTHKYPPLMIDSSVD-----------TTDLHQNNEMNS 494

  Fly   458 VQAFINEWFMEHPSGKVHQ---------------------ILIVIVLGM-IALFWYTCSTMRELQ 500
            ::.:::...:|....|:|:                     :..:|..|: :.||...|:.::..:
Yeast   495 LKEYMSPEDLEAYRKKIHEQISRELDEKNQNSLLLKFGSLVYRIIETGVFLLLFLIFCAILQRFK 559

  Fly   501 -------------------------------KQSENGSKTFAIAQNG---------SNGSTGSNG 525
                                           ..|||.:|.|.: ::|         ::||..|..
Yeast   560 ILPPLYVLLSKIGFMPEKEIPIVESKSLNCPSSSENVTKPFDM-KSGKQVVFEGAVNDGSLKSEK 623

  Fly   526 SNANA----EDLVDL------------GNGQVRVGKISFSTN------------EVLGKGCEGTF 562
            .|.:|    |..:||            |..:.|..:|:...|            ::||.|..||.
Yeast   624 DNDDADEDDEKSLDLTTEKKKRKRGSRGGKKGRKSRIANIPNFEQSLKNLVVSEKILGYGSSGTV 688

  Fly   563 VFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQ 627
            ||:|:|:.|.|||||:|.:....|..|:.||.|||.|.||:||:|:|...:|.|||:|||...||
Yeast   689 VFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQ 753

  Fly   628 DYTE----GDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPD--------A 680
            |..|    .|.:|:||...:...:|.|.|||::|||||.|:|||:||||:|:|...        .
Yeast   754 DLVESKNVSDENLKLQKEYNPISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTG 818

  Fly   681 KGKVRVMISDFGLCKKLNFGKTSF-SRRSGVTGTDGWIAPEMMR--------------------- 723
            ...:|::||||||||||:.|::|| :..:..:||.||.|||::.
Yeast   819 AENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVV 883

  Fly   724 ----------SQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSE 778
                      .:|.|.::||||:|||:||:||.|.|.|||...|::||:...::|.:::...|
Yeast   884 SSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIRGIFSLDEMKCLHD-- 946

  Fly   779 DSRIILAE--QLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKS 841
              |.::||  .|||.||..||..||.|..:..|||||.:.|.|.||..||||:| ::....|...
Yeast   947 --RSLIAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKLEFLLKVSDRLE-IENRDPPSAL 1008

  Fly   842 LEK----NGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKML 902
            |.|    :..::...||.|..|....|:|.:||.|..:.:.|||||||||.||:.:|.....:::
Yeast  1009 LMKFDAGSDFVIPSGDWTVKFDKTFMDNLERYRKYHSSKLMDLLRALRNKYHHFMDLPEDIAELM 1073

  Fly   903 GCIPHEFTNYWVDRFPQLISHAY 925
            |.:|..|.:|:..|||.|:...|
Yeast  1074 GPVPDGFYDYFTKRFPNLLIGVY 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	65/312 (21%)
		STKc_IRE1	545..813	CDD:270884	127/325 (39%)
		RNase_Ire1	817..941	CDD:199217	42/113 (37%)
IRE1	NP_011946.1	Luminal_IRE1	120..407	CDD:188875	65/309 (21%)
		STKc_IRE1	672..981	CDD:270884	125/312 (40%)
		RNase_Ire1	984..1113	CDD:199217	42/114 (37%)