DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and IRE1-1

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001190382.1	Gene:	IRE1-1 / 832507	AraportID:	AT5G24360	Length:	887	Species:	Arabidopsis thaliana

Alignment Length:	1006	Identity:	271/1006 - (26%)
Similarity:	434/1006 - (43%)	Gaps:	283/1006 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DLARDEEALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHF-----------LP 100
            |:.| |...::.||:.|.::.:|..:.::.||...:.||.:.:    |.||:           |.
plant    47 DIYR-ESGYVLVSTVDGSISLVDMSSQKLDWTFHTNEPIYSSY----QAPHYHYTTDEERSSVLG 106

  Fly   101 D------PRDGSIYQLGQMGSLKK----------------LPYTIPQLVANAPCRSSDGILYSGK 143
            |      .:|..:|.    .|::|                ||||           |:|.|:. ||
plant   107 DDFYMDCDKDWRLYN----SSVRKGKRVNEIVDASEFIGTLPYT-----------STDRIVL-GK 155

  Fly   144 KSDTWYMVDPKTG---RREKVMGFGDATVDGKEGEQIGWATSRAIYLGRTQYTVMMYDSLAKNKD 205
            |..:.:::|.|||   :|.::......||...:.|       :||.|.: :..::......|::|
plant   156 KDTSVFLLDWKTGKLVKRYRMDELYSNTVVENDKE-------KAIVLSK-EAPLLFGSGFKKSED 212

  Fly   206 AKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLLGP 270
            .                |||                 |.::||        |.....::.|   .
plant   213 F----------------PEL-----------------VYIERK--------DFKIQCISKF---G 233

  Fly   271 DGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKGLYALPSLVDKNTPRIS---T 332
            |.|.||.:..:          |:|..|..:|:.            :..|.|.|.||...:|   :
plant   234 DVLWSVSYAKM----------EAKLQNHESVQF------------ISGLSSSVGKNQFPLSYTTS 276

  Fly   333 APPIKLLDGPTGDQNSNQET-DPRTIYINDVL----QEHAGIMLGHYNMPNE---GNGNLQLSPT 389
            .|.::|       :|...|| .||..::::.|    |:         ..||:   |:||....|.
plant   277 VPMVQL-------RNVKYETLFPRLGFLDEALYLPFQD---------RKPNQLAIGDGNQLTLPG 325

  Fly   390 TASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQN 454
            ...::.|.||..                          ||.|   |.|.|:          |:..
plant   326 NKEAEEVLSLPL--------------------------PETV---ISQITD----------IIDG 351

  Fly   455 SNKVQAFINEWFMEHPSGKVHQILI----VIVLGMIALFWYTCSTMREL--------------QK 501
            |.|...|.:::     ||.:  :||    |.:|.:..||:|.......:              :|
plant   352 STKQAGFASKF-----SGLI--VLIFGFCVTMLSVCGLFFYRLRQSIRIKEPYVSEVPIATPKKK 409

  Fly   502 QSENGSKTFAIAQNGSNGSTGSNGSNANAED-------LVDLGNGQV---RVGKISFSTNEVLGK 556
            :|:....|.|:.:..:...:|.|...::.|:       ...|.|...   ||||: |.:|:.:.|
plant   410 KSKKNGTTKAVHKKENGFISGGNKDPSHEENEKRLLTAFPGLNNSSAEGYRVGKL-FVSNKEIAK 473

  Fly   557 GCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVEL 621
            |..||.|.:|::|.|.||||||:......|.:|:..|..||.|.|:||::..:||..|.||::||
plant   474 GSNGTVVLEGSYEGRLVAVKRLVQSHHDVAQKEILNLMASDKHSNIVRWYGVDQDEHFIYISLEL 538

  Fly   622 CAATLQDYTEGDRSL-------------------ELQNHIDVW-----------QVLSQAASGLS 656
            ||.:|.|......:|                   |....:::|           :::....:||.
plant   539 CACSLNDLIYASSALLESPMASSSIHSIQINPIFENGKGVELWKENGHPSPVLLKLMRDIVAGLV 603

  Fly   657 HLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRS-GV-TGTDGWIAP 719
            |||.:.|||||:|||||||.   ....:...:||.|:.|:|....::.:|.| |: :|:.||.||
plant   604 HLHDIGIVHRDLKPQNVLIV---KNSSLCAKLSDMGISKRLPADTSALTRNSTGLGSGSSGWQAP 665

  Fly   720 EMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLR--PEDDSEDSRI 782
            |.:|::|.|.|||:||||||.::.::||.|.:|||.:|..|:|:.:.:|..:.  ||
plant   666 EQLRNERQTRAVDLFSLGCVLFFCMTGGKHPYGDNYERDVNVLNDQKDLFLIESLPE-------- 722

  Fly   783 ILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRV--EKLQFHAEPLKSLEKN 845
              |..|::.:::.||..||.|:.:.:|||||:....||||:|.||||  |..:..::.|.:||..
plant   723 --AVHLLTGLLNPDPNLRPRAQDVMHHPLFWNSDMRLSFLRDASDRVELENREEGSQLLAALEST 785

  Fly   846 GRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFT 910
            ..:.:...|:..||.:..|::.:||.|...|:|||||.:|||.:||.||....|::||.:|..|.
plant   786 AAVTLNGRWDEKLDSIFLDNIGRYRRYKFDSIRDLLRVIRNKLNHYRELPKELQELLGSVPEGFE 850

  Fly   911 NYWVDRFPQLISHAYHA-FSICSNEPIFKPY 940
            .|:..|||:|:...|.. |..|:||..|..|
plant   851 RYFSSRFPKLLIQVYTVLFDYCNNEEFFFKY 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	57/303 (19%)
		STKc_IRE1	545..813	CDD:270884	105/301 (35%)
		S_TKc	552..812	CDD:214567	101/293 (34%)
		RNase_Ire1	817..941	CDD:199217	50/127 (39%)
IRE1-1	NP_001190382.1	Luminal_IRE1_like	54..398	CDD:188873	99/499 (20%)
		PKc_like	463..751	CDD:304357	105/301 (35%)
		S_TKc	469..750	CDD:214567	101/293 (34%)
		RNase_Ire1	755..881	CDD:199217	49/125 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I1065
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm2491
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	O	PTHR13954
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.780