DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and IRE1A

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_565419.1	Gene:	IRE1A / 816258	AraportID:	AT2G17520	Length:	841	Species:	Arabidopsis thaliana

Alignment Length:	933	Identity:	245/933 - (26%)
Similarity:	391/933 - (41%)	Gaps:	241/933 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 APC-RSSDGILY------SGKKSDTWYMVDPKTGRREKVMGFGDATVDGKE--GEQIGWATSRAI 185
            :|| .::|.:.|      .|::|......:|.|....|::...|..|..|:  .|...|:.|
plant    24 SPCGGAADDVTYPIVPSSPGRRSILQIRREPPTEPNTKLVVDRDGKVFLKQQPKETPYWSFS--- 85

  Fly   186 YLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHG 250
             .|...::  :|.:.|.|.......||         .|.:..||      ...:....|:|..|.
plant    86 -TGSPMHS--LYQAPANNNTENATEIT---------RPHIIVEY------LNNSKAATTVDGYHN 132

  Fly   251 KFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKG 315
            ..:.:.....|:|.     .||:      |:..|...|.|.:.::|.:  :.:::|
plant   133 WTVQEFFRQKPLVT-----DDGV------TLGSETTSAYLVDGRSGRL--IHVYKS--------- 175

  Fly   316 LYALPSLVDKNTPRISTAPPIKLLDGPTGDQN-SNQETDPRTI--YIND-VLQEHAGIMLGHYNM 376
                                       |||.. :|....|.:.  ::|: :|.......|.|:
plant   176 ---------------------------TGDTKITNALVKPASTEDFVNEPLLIRRTDSKLEHF-- 211

  Fly   377 PNEGNGNLQLSPTTASSKVVQSLATIH---------NYNDGYGLLANNEKNAADI------GVQT 426
                      |.||  .|:|.:|...|         .:|.||.|   ..|....|      |.|.
plant   212 ----------SKTT--GKLVWNLTVSHFRAALLCDPVFNSGYDL---GPKLQTGIYMPLLCGSQI 261

  Fly   427 D---PELV-EIGIDQRTN--------------GNTI------NRTKTIILQNSNKVQAFINEWFM 467
            |   ||:| .:..||..|              .|:|      ..::.:..|:..|......:|
plant   262 DVRGPEIVIRVLHDQPMNVKMLPSPSLNHFESENSIMPFGKARESRKLQEQHKQKYTYLFGQW-- 324

  Fly   468 EHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIA------QNGSNGSTGSNGS 526
                ..|..:..:::||::...:        ::|.|..||.....|      :|..:....:..|
plant   325 ----SPVKLLAPLVLLGVVVSVF--------IKKFSSRGSDVSLKAGPSKKKKNRKSAKDTNRQS 377

  Fly   527 NANAEDLVDL-GNGQV---------------RVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAV 575
            ....:|..:| ..||:               ::||:..|:.|: .||..||.||:|.:|.|.|||
plant   378 VPRGQDQFELIEGGQMLLGFNNFQSGATDGRKIGKLFLSSKEI-AKGSNGTVVFEGIYEGRPVAV 441

  Fly   576 KRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDY----------- 629
            |||:......|.:|:..|..||.|.|::|::..|.|:.|.|:::|.|..:|.|.
plant   442 KRLVRSHHEVAFKEIQNLIASDQHTNIIRWYGVEYDQDFVYLSLERCTCSLDDLIKSYLEFSMTK 506

  Fly   630 -------TEGDRSLELQNHID----------VWQV-----------LSQAASGLSHLHSLDIVHR 666
                   |||..:.::|  :|          .|:|           :.....|:.|||.|.||||
plant   507 VLENNDSTEGVAAYKIQ--LDSLEGVIKGNNFWKVGGHPSPLMLKLMRDIVCGIVHLHELGIVHR 569

  Fly   667 DIKPQNVLISLP---DAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTT 728
            |:||||||||..   .||      :||.|:.|:::...:|....:..:|:.||.|||.:...|.|
plant   570 DLKPQNVLISKDMTLSAK------LSDMGISKRMSRDMSSLGHLATGSGSSGWQAPEQLLQGRQT 628

  Fly   729 TAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLR--PEDDSEDSRIILAEQLISD 791
            .|||:||||||.:|.::|..|.|||:|:|..||:.::.:|..:.  ||          |..|||.
plant   629 RAVDMFSLGCVIFYTITGCKHPFGDDLERDVNIVKNKVDLFLVEHVPE----------ASDLISR 683

  Fly   792 MIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRV--EKLQFHAEPLKSLEKNGRIVVLDDW 854
            :::.||..||.|..:..||:||:....||||:|.||||  |..:..:|.||::|....:.:...|
plant   684 LLNPDPDLRPSATEVLLHPMFWNSEMRLSFLRDASDRVELENREADSEILKAMESTAPVAIGGKW 748

  Fly   855 NVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQ 919
            :..|:|:...::.:||.|...|:|||||.:|||.:|:.||.|..|:::|.:|..|..|:..|||:
plant   749 DEKLEPVFITNIGRYRRYKYDSIRDLLRVIRNKLNHHRELPPEIQELVGTVPEGFDEYFAVRFPK 813

  Fly   920 LISHAYHAFSI-CSNEPIFKPYY 941
            |:...|...|: |..|.:|:.|:
plant   814 LLIEVYRVISLHCREEEVFRKYF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	37/199 (19%)
		STKc_IRE1	545..813	CDD:270884	107/311 (34%)
		S_TKc	552..812	CDD:214567	105/303 (35%)
		RNase_Ire1	817..941	CDD:199217	47/126 (37%)
IRE1A	NP_565419.1	Luminal_IRE1_like	62..>240	CDD:276097	45/261 (17%)
		STKc_IRE1	412..705	CDD:270884	107/311 (34%)
		RNase_Ire1	708..836	CDD:199217	47/127 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	178	1.000	Domainoid score	I1065
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm2491
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.780