Protein Alignment Ire1 and IRE1A

DIOPT Version :10

• Sequence 1: NP_001097839.1
• Gene: Ire1 / 42358
• FlyBaseID: FBgn0261984
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_565419.1
• Gene: IRE1A / 816258
• AraportID: AT2G17520
• Length: 841
• Species: Arabidopsis thaliana
• Alignment Length: 931
• Identity: 245/931 - (26%)
• Similarity: 391/931 - (41%)
• Gaps: 237/931 - (25%)

  Fly   130 APC-RSSDGILY------SGKKSDTWYMVDPKTGRREKVMGFGDATVDGKE--GEQIGWATSRAI 185
            :|| .::|.:.|      .|::|......:|.|....|::...|..|..|:  .|...|:.|
plant    24 SPCGGAADDVTYPIVPSSPGRRSILQIRREPPTEPNTKLVVDRDGKVFLKQQPKETPYWSFS--- 85

  Fly   186 YLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHG 250
             .|...::  :|.:.|.|.......||         .|.:..||      ...:....|:|..|.
plant    86 -TGSPMHS--LYQAPANNNTENATEIT---------RPHIIVEY------LNNSKAATTVDGYHN 132

  Fly   251 KFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKG 315
            ..:.:.....|:|.     .||:      |:..|...|.|.:.::|.:  :.:::|
plant   133 WTVQEFFRQKPLVT-----DDGV------TLGSETTSAYLVDGRSGRL--IHVYKS--------- 175

  Fly   316 LYALPSLVDKNTPRISTAPPIKLLDGPTGDQN-SNQETDPRTI--YIND-VLQEHAGIMLGHYNM 376
                                       |||.. :|....|.:.  ::|: :|.......|.|:
plant   176 ---------------------------TGDTKITNALVKPASTEDFVNEPLLIRRTDSKLEHF-- 211

  Fly   377 PNEGNGNLQLSPTTASSKVVQSLATIH---------NYNDGYGLLANNEKNAADI------GVQT 426
                      |.||  .|:|.:|...|         .:|.||.|   ..|....|      |.|.
plant   212 ----------SKTT--GKLVWNLTVSHFRAALLCDPVFNSGYDL---GPKLQTGIYMPLLCGSQI 261

  Fly   427 D---PELV-EIGIDQRTN--------------GNTI------NRTKTIILQNSNKVQAFINEWFM 467
            |   ||:| .:..||..|              .|:|      ..::.:..|:..|......:|
plant   262 DVRGPEIVIRVLHDQPMNVKMLPSPSLNHFESENSIMPFGKARESRKLQEQHKQKYTYLFGQW-- 324

  Fly   468 EHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIA------QNGSNGSTGSNGS 526
                ..|..:..:::||::...:        ::|.|..||.....|      :|..:....:..|
plant   325 ----SPVKLLAPLVLLGVVVSVF--------IKKFSSRGSDVSLKAGPSKKKKNRKSAKDTNRQS 377

  Fly   527 NANAEDLVDL-GNGQV---------------RVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAV 575
            ....:|..:| ..||:               ::||:..|:.|: .||..||.||:|.:|.|.|||
plant   378 VPRGQDQFELIEGGQMLLGFNNFQSGATDGRKIGKLFLSSKEI-AKGSNGTVVFEGIYEGRPVAV 441

  Fly   576 KRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQD----YTEGDRSL 636
            |||:......|.:|:..|..||.|.|::|::..|.|:.|.|:::|.|..:|.|    |.|...:.
plant   442 KRLVRSHHEVAFKEIQNLIASDQHTNIIRWYGVEYDQDFVYLSLERCTCSLDDLIKSYLEFSMTK 506

  Fly   637 ELQNH------------ID----------VWQV-----------LSQAASGLSHLHSLDIVHRDI 668
            .|:|:            :|          .|:|           :.....|:.|||.|.|||||:
plant   507 VLENNDSTEGVAAYKIQLDSLEGVIKGNNFWKVGGHPSPLMLKLMRDIVCGIVHLHELGIVHRDL 571

  Fly   669 KPQNVLISLP---DAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTA 730
            ||||||||..   .||      :||.|:.|:::...:|....:..:|:.||.|||.:...|.|.|
plant   572 KPQNVLISKDMTLSAK------LSDMGISKRMSRDMSSLGHLATGSGSSGWQAPEQLLQGRQTRA 630

  Fly   731 VDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLR--PEDDSEDSRIILAEQLISDMI 793
            ||:||||||.:|.::|..|.|||:|:|..||:.::.:|..:.  ||          |..|||.::
plant   631 VDMFSLGCVIFYTITGCKHPFGDDLERDVNIVKNKVDLFLVEHVPE----------ASDLISRLL 685

  Fly   794 HKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRV--EKLQFHAEPLKSLEKNGRIVVLDDWNV 856
            :.||..||.|..:..||:||:....||||:|.||||  |..:..:|.||::|....:.:...|:.
plant   686 NPDPDLRPSATEVLLHPMFWNSEMRLSFLRDASDRVELENREADSEILKAMESTAPVAIGGKWDE 750

  Fly   857 HLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLI 921
            .|:|:...::.:||.|...|:|||||.:|||.:|:.||.|..|:::|.:|..|..|:..|||:|:
plant   751 KLEPVFITNIGRYRRYKYDSIRDLLRVIRNKLNHHRELPPEIQELVGTVPEGFDEYFAVRFPKLL 815

  Fly   922 SHAYHAFSI-CSNEPIFKPYY 941
            ...|...|: |..|.:|:.|:
plant   816 IEVYRVISLHCREEEVFRKYF 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	37/199 (19%)
		STKc_IRE1	545..813	CDD:270884	107/309 (35%)
		RNase_Ire1	817..941	CDD:199217	47/126 (37%)
IRE1A	NP_565419.1	Luminal_IRE1_like	62..>240	CDD:276097	45/261 (17%)
		STKc_IRE1	412..705	CDD:270884	107/309 (35%)
		RNase_Ire1	708..836	CDD:199217	47/127 (37%)