DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and RNASEL

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_066956.1	Gene:	RNASEL / 6041	HGNCID:	10050	Length:	741	Species:	Homo sapiens

Alignment Length:	814	Identity:	174/814 - (21%)
Similarity:	301/814 - (36%)	Gaps:	257/814 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 NITFYD--------YNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHG--KFLWQRDLSSPVVA 264
            |:.|.:        :|||    ::::|            .||.|..:||  ..|.:::.::|.:.
Human    50 NVNFQEEEGGWTPLHNAV----QMSRE------------DIVELLLRHGADPVLRKKNGATPFIL 98

  Fly   265 AFLLGPDGLLSVPFTTVSD------EAYQAILEESKTGNVNTVKLFQSLY-----------VGEH 312
            |.:.|...||.:..:..:|      ..:.|.:|.:..|.|..:|.   ||           ..|.
Human    99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF---LYKRGANVNLRRKTKED 160

  Fly   313 QK-----GLYALPSLVDKNTPRISTAPPIK-LLDGPTGDQNSNQETDPRTIYINDVLQEHAGIML 371
            |:     |..||....:|....:     :| |||....|.|:
Human   161 QERLRKGGATALMDAAEKGHVEV-----LKILLDEMGADVNA----------------------- 197

  Fly   372 GHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVEIGID 436
                ..|.|..                 |.||      .||::::   :|:...|. .|::.|.|
Human   198 ----CDNMGRN-----------------ALIH------ALLSSDD---SDVEAITH-LLLDHGAD 231

  Fly   437 QRTNGNTINRTKT-IILQNSNK----VQAFINEWFME----HPSGKVHQILIVIVLGMIALFWYT 492
            ....|   .|.|| :||....|    ||..:.:..:|    ...||...:|.|.:
Human   232 VNVRG---ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL---------- 283

  Fly   493 CSTMRELQKQSENGSKTFAIAQNGSNGSTG-------------------SNGSNAN----AED-- 532
                 :|:|.:|      .:.:.|::...|                   |:|:..:    |||
Human   284 -----KLKKIAE------LLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWK 337

  Fly   533 ---------LVDLGN-GQVRVGKISFSTNE--VLGKGCEGTFVFKGTFEERFVAVKRLLPECFTF 585
                     |.||.. .:..:||:.|..:|  .:....||. ::.|.:|::.||||       ||
Human   338 PQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGG-IYLGFYEKQEVAVK-------TF 394

  Fly   586 ------ADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDV 644
                  |.|||:.|:.|..:.::|.::.:|..|...::.|.||..||:...:..|..:::|..|.
Human   395 CEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDE 459

  Fly   645 W--QVLSQAASGLSHLH-SLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSR 706
            :  .|||.....:..|| |....|:|::|||:||.     .|....::||....|
Human   460 FARNVLSSIFKAVQELHLSCGYTHQDLQPQNILID-----SKKAAHLADFDKSIK---------- 509

  Fly   707 RSGVTGTDGWIA-PEMMRSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAK 770
                     |.. |:.::.       |:..||.:..||:..|..:|.| ||.|:|     ..:.:
Human   510 ---------WAGDPQEVKR-------DLEDLGRLVLYVVKKGSISFED-LKAQSN-----EEVVQ 552

  Fly   771 LRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDR--VEKLQ 833
            |.|:::::|        ||..:.|.....|.....:..||.||........|::|.:.  ::..:
Human   553 LSPDEETKD--------LIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRK 609

  Fly   834 FHAEPLKSLE--KNGRIVVLDDWNVHLDPMITDDLRKY---RG-YMGASVRDLLRALRNKKHHYH 892
            ..:|.|:.|:  .:......|.|...::..:...:.|:   || :...:|.|||:.:||...|..
Human   610 SESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHID 674

  Fly   893 ELTPAAQKM-LGCIPHEFTNYWVDRFPQLISHAY 925
            |......|: :|    :.:.|:...||.|:.:.|
Human   675 EEKHKKMKLKIG----DPSLYFQKTFPDLVIYVY 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	30/142 (21%)
		STKc_IRE1	545..813	CDD:270884	70/279 (25%)
		S_TKc	552..812	CDD:214567	68/271 (25%)
		RNase_Ire1	817..941	CDD:199217	25/118 (21%)
RNASEL	NP_066956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..56	CDD:293786	2/5 (40%)
		ANK 1	24..53		1/2 (50%)
		Ank_2	29..122	CDD:289560	18/87 (21%)
		ANK 2	58..87		9/44 (20%)
		ANK	59..188	CDD:238125	30/152 (20%)
		ANK repeat	59..89	CDD:293786	10/45 (22%)
		ANK repeat	91..122	CDD:293786	6/30 (20%)
		ANK 3	91..120		6/28 (21%)
		Ank_2	96..199	CDD:289560	24/137 (18%)
		ANK repeat	124..154	CDD:293786	7/32 (22%)
		ANK 4	124..153		7/31 (23%)
		ANK repeat	167..199	CDD:293786	10/63 (16%)
		ANK 5	167..197		9/34 (26%)
		Ank_2	172..270	CDD:289560	30/159 (19%)
		ANK	196..321	CDD:238125	32/202 (16%)
		ANK repeat	201..236	CDD:293786	11/61 (18%)
		ANK 6	201..234		11/59 (19%)
		2-5A binding (P-loop) 1	229..242		5/15 (33%)
		ANK 7	238..268		9/29 (31%)
		Ank_2	243..326	CDD:289560	17/103 (17%)
		2-5A binding (P-loop) 2	253..275		4/21 (19%)
		ANK repeat	272..326	CDD:293786	11/74 (15%)
		ANK 8	272..301		8/49 (16%)
		ANK 9	303..329		2/25 (8%)
		PKc_like	375..587	CDD:304357	67/264 (25%)
		Pkinase	387..586	CDD:278497	63/250 (25%)
		RNase_RNase-L	590..708	CDD:199218	25/119 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..741
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810