DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and Ern1

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_038942575.1	Gene:	Ern1 / 498013	RGDID:	1559716	Length:	982	Species:	Rattus norvegicus

Alignment Length:	990	Identity:	386/990 - (38%)
Similarity:	543/990 - (54%)	Gaps:	161/990 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGS-- 115
            |||:..|||.|.|.|:...|..|:||:.:||  |.:...:|:.|.|||||.|||:|.||...:
  Rat    37 EALLFVSTLDGSLHAVSKRTGSIKWTLKEDP--VLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEG 99

  Fly   116 LKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVM--GFGDATVDGKEGEQIG 178
            |.|||:|||:||..:||||||||||.|||.|.||::|..||.:::.:  .|.|:..
  Rat   100 LTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLC--------- 155

  Fly   179 WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIV 243
             .::..:|||||:||:.|||:  |.::.: ||.|::||.|  :.||...:|:..|..:..:|.:|
  Rat   156 -PSTSLLYLGRTEYTITMYDT--KTRELR-WNATYFDYAA--SLPEDDVDYKMSHFVSNGDGLVV 214

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTV------- 301
            |:|.:.|..||.::.:|||||.::...:||..|....|:.|..:.:...|  |.|..:
  Rat   215 TVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMS--GEVGRITKWKYPF 277

  Fly   302 --------KLFQSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGP------TGDQ--- 346
                    ||..:||||::...|||.||:|.:.   .||.||.|   ||:||      .||:
  Rat   278 PKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLP---LLEGPQTDGVTIGDKGEC 339

  Fly   347 ----NSNQETDP------RTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLAT 401
                :::.:.||      :..|:.:.     .:::||:.           :|.:||:|:::....
  Rat   340 VITPSTDLKFDPGLKGKSKLNYLRNY-----WLLIGHHE-----------TPLSASTKMLERFPN 388

  Fly   402 ---IHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSN------- 456
               .|..|   .:.|::||.:.:       |::.:      .|.|...|.|.:.|:..
  Rat   389 NLPKHREN---VIPADSEKRSFE-------EVINL------VGQTSENTPTTVSQDVEEKLPRAP 437

  Fly   457 -KVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQ------------------ 502
             |.:|.::....:..:..:...|:|..:..|..:..:....|:||.|
  Rat   438 AKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLP 502

  Fly   503 ---------------------SENGSKTFAIAQNGSNGSTGSNGSNANA-------EDLVDLGNG 539
                                 ..:|:.:.:.:...||.|..|:.|.:.|       .|..|....
  Rat   503 FHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETR 567

  Fly   540 QVRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVR 604
            .|.||||||...:|||.|.|||.|:||.|:.|.|||||:|||||:||||||.||||||.|.||:|
  Rat   568 MVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIR 632

  Fly   605 YFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIK 669
            |||||:||||:|||:||||||||:|.|......|  .::...:|.|..|||:|||||:|||||:|
  Rat   633 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLHQTTSGLAHLHSLNIVHRDLK 695

  Fly   670 PQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---SQRTTTAV 731
            |.|:|:|:|:|.|:::.|||||||||||..|:.||||||||.||:|||||||:.   .:..|..|
  Rat   696 PHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTV 760

  Fly   732 DIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKD 796
            ||||.|||:|||:|.|:|.||.:|:||||||....:|.... .|..||   ::|.:||..||..|
  Rat   761 DIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFH-SDKHED---VIARELIEKMIAMD 821

  Fly   797 PQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPM 861
            ||.||.|:.:..||.||...|.|.|.||||||:||.......::.||:.||.||..||..::...
  Rat   822 PQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVP 886

  Fly   862 ITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYH 926
            :..||||:|.|.|.||||||||:|||:|||.||....|:.||.||.:|..|:..|||.|:||.|.
  Rat   887 LQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYR 951

  Fly   927 AFSICSNEPIFKPYY 941
            |..:|.:|.:|:.||
  Rat   952 AMELCRHERLFQTYY 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	109/286 (38%)
		STKc_IRE1	545..813	CDD:270884	158/270 (59%)
		S_TKc	552..812	CDD:214567	154/262 (59%)
		RNase_Ire1	817..941	CDD:199217	60/123 (49%)
Ern1	XP_038942575.1	Luminal_IRE1	37..305	CDD:188875	109/286 (38%)
		STKc_IRE1	573..838	CDD:270884	158/270 (59%)
		RNase_Ire1	841..966	CDD:199217	60/124 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1346
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55580
Inparanoid	1	1.050	611	1.000	Inparanoid score	I880
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm44942
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	O	PTHR13954
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840