DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and Ern2

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001102389.1	Gene:	Ern2 / 365363	RGDID:	1308743	Length:	927	Species:	Rattus norvegicus

Alignment Length:	968	Identity:	368/968 - (38%)
Similarity:	504/968 - (52%)	Gaps:	180/968 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLG---QMG 114
            |:|:..|||.|.|.|::..|.:::||:.|||  :.:....|....||.||.|||:|.||   |.|
  Rat    37 ESLLFVSTLDGSLHALNKQTGDLKWTVKDDP--IIQGPMYVTEMAFLSDPADGSLYILGTQKQQG 99

  Fly   115 SLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGW 179
             |.|||:|||:||..:|||||||:.|:|:|.|.|::|||::|..:..:     |.:|....|
  Rat   100 -LMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTL-----TTEGFSTPQ--- 155

  Fly   180 ATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYI-HLTTTTNGQIV 243
                 :|:|||||||.|:|   .......||.|:..|   ||||......:|: |||:...|.::
  Rat   156 -----LYIGRTQYTVSMHD---PRTPTLRWNTTYRRY---SAPPVDGSPGKYMSHLTSCGMGLLL 209

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVS-DEAYQAILEESKTGNV--------N 299
            |:|...|..||.:||..||...:....|||..:|..|:: |..:..:|   :.|::        :
  Rat   210 TVDPGSGTVLWTQDLGVPVTGIYTWHQDGLRQLPHLTLARDTLHFLVL---RWGHIRLPASSSQD 271

  Fly   300 TVKLFQS--------LYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGPTGDQNSNQETD 353
            ||..|.|        ||||:.:.|.|...:||...   .||..|..|   :||||        ||
  Rat   272 TVTQFSSLDTELLMTLYVGKEEAGFYVSKALVHAGVALVPRGLTLAP---MDGPT--------TD 325

  Fly   354 PRTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKN 418
            ..|:.:                     :|..:.||:||......|:|....:     ||
  Rat   326 EVTVQV---------------------SGEREGSPSTAVRYPSGSVALPSQW-----LL------ 358

  Fly   419 AADIGVQTDPELVEIGI--DQRTNGNTINRTKTIILQNSNKVQA------FIN-----EWFME-H 469
               ||....|.::...:  .|||.|.....|:     :|:.:.|      |:|     .|..| |
  Rat   359 ---IGYHEPPPVLHTTMLRVQRTPGKGSADTR-----DSDDLHAPALSFEFLNLKREEPWDPELH 415

  Fly   470 PSGKV-------HQILIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSN 527
            |..|.       .|.|:......|.|..:....||: |:||.               |..:..|:
  Rat   416 PEEKADTYPGLGSQDLLAASFTAILLGAWVLYLMRQ-QQQSP---------------SAPAGPSD 464

  Fly   528 ANAEDLVDLGNGQVR-------------------------VGKISFSTNEVLGKGCEGTFVFKGT 567
            ...:..|.|....::                         ||||||:..:|||:|..|||||:|.
  Rat   465 LPQDTQVQLSRDTLQNQRRFQSPPEPVQPAHDPEAEQPTVVGKISFNPKDVLGRGAGGTFVFRGQ 529

  Fly   568 FEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEG 632
            ||.|.|||||||.|||:...|||.||:|||.|.||:|||||||..||.|||:|||.|:||:|.|.
  Rat   530 FEGRAVAVKRLLRECFSLVQREVQLLQESDRHPNVLRYFCTEQGPQFHYIALELCQASLQEYVES 594

  Fly   633 DRSLELQNHIDVW-----QVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFG 692
            .       .:|.|     .||.|..|||:|||||.|||||:||.|:|::.||::|:.||:|||||
  Rat   595 P-------DLDRWGLGPTMVLQQMMSGLAHLHSLHIVHRDLKPGNILMAGPDSQGQGRVVISDFG 652

  Fly   693 LCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR--SQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNL 755
            |||||..|:.|||..||:.||:||:|||:::  ....|:||||||.|||:|||||||.|.||::|
  Rat   653 LCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGESL 717

  Fly   756 KRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLS 820
            .|||||||.::.||:|:.|...:    ::|..|:..|:...||.||.|..:..|||||...|.|.
  Rat   718 YRQANILSGDHCLAQLQEETHDK----VVALDLVKAMLSLLPQDRPSAGWVLAHPLFWSRAKELQ 778

  Fly   821 FLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALR 885
            |.|||||.:||.......:.:||.....||.::|..|:...:.:||:::|.|.|.||||||||:|
  Rat   779 FFQDVSDWLEKEPEQGPLVTALEAGSYKVVRENWYKHISAPLQEDLKRFRSYKGTSVRDLLRAMR 843

  Fly   886 NKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSA 943
            ||||||.||....::.||.:|..|..|:..|||:|:.|.:.|...|::|.:|.|||.|
  Rat   844 NKKHHYRELPTEVRQTLGQLPAGFAQYFTQRFPRLLLHTHRAMRTCASESLFLPYYPA 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	105/288 (36%)
		STKc_IRE1	545..813	CDD:270884	151/274 (55%)
		S_TKc	552..812	CDD:214567	146/266 (55%)
		RNase_Ire1	817..941	CDD:199217	53/123 (43%)
Ern2	NP_001102389.1	Luminal_IRE1	37..365	CDD:188875	129/398 (32%)
		PQQ	<40..236	CDD:224437	85/217 (39%)
		STKc_IRE1	507..771	CDD:270884	151/274 (55%)
		S_TKc	510..770	CDD:214567	147/270 (54%)
		RNase_Ire1	774..899	CDD:199217	53/124 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335280
Domainoid	1	1.000	303	1.000	Domainoid score	I1346
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I880
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		otm44942
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770