DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and ire1

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_593384.1	Gene:	ire1 / 2542776	PomBaseID:	SPAC167.01	Length:	1072	Species:	Schizosaccharomyces pombe

Alignment Length:	1067	Identity:	284/1067 - (26%)
Similarity:	455/1067 - (42%)	Gaps:	266/1067 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VFSTLGGGLTAIDPVTSEIRWTIAD--DPPIVAEHQEN--------------------------- 92
            :.:|:.|.|.:.|.:|.:..|::..  :|.:.....||
pombe    86 IVATVDGSLHSYDRITGQELWSLFTNANPGLSYTKDENSLLSSKFLSQSNFKSYNSTHGEFYSDS 150

  Fly    93 -VQVPHFLPD-------PRDGSI-YQLGQMGSLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTW 148
             :.:.:...|       |.||.| |.......|.:||::|..||..:|.|..:..::.|.|:.|.
pombe   151 TLNISYLSDDDTVWFVEPIDGGILYAFNLQTGLVRLPHSIKDLVHASPIRLLNNNVFVGSKNTTL 215

  Fly   149 YMVDPKTG-----------------------RREKVMGFGDATVDGKE----------------G 174
            :.:|...|                       :|:.|....|:.:..|:                .
pombe   216 FTIDVSNGDIVSQYPSGHRYETHHSVHNLGTKRDSVPSGADSDLSFKDPSGKKLSESLDLLDDFN 280

  Fly   175 EQIGWATSRAIYLGRTQYTVMMYD-------------SLAKNKDAKPWNITFYDYNAVSAPPELA 226
            .|:..:....:.:.||:|.:.:|.             :..||:      |.:..:::.|...:||
pombe   281 YQVTVSNKSFVDIARTEYFITIYSDSNVILDLVYIDWTPTKNE------IMYESFHSSSFDSKLA 339

  Fly   227 -KEYE-YIHLTTTTNGQIVTLDRKHGKFLWQR-DLSSPVVAAF--LLGPDG-------------- 272
             ..|: .:|:..|           |.||:.|. .|.||....|  :..|..
pombe   340 LSSYDSSLHIVDT-----------HSKFIKQNIPLMSPAATVFDIVTLPHNKKIDKSQTPAKFPT 393

  Fly   273 --LLSVPFTTVSDEAYQAILEESKTGNVNTVKLFQSLYVGEHQKGLYALPSLVDKNTPRISTAPP 335
              ||..|..|..:..:..| ..:||.:|         |:.......:|:.   :::.|.:|.||.
pombe   394 SVLLRQPIDTYLETMFPQI-ARNKTEHV---------YINHIGNAWFAMS---ERHYPLVSLAPE 445

  Fly   336 IKLL--DGPTGDQNSNQETDPRTIYI--NDVLQEHAGIM-----------LGHYNMPN--EGNGN 383
            ...|  :|               .||  |.:...|: :|           |..|::|:  |..|:
pombe   446 ASFLYYNG---------------FYIPLNSIFGLHS-LMATPKPFFALPGLPGYDIPSYVESEGS 494

  Fly   384 LQ------------LSPTTASSK-------VVQSLATIHNYNDGYGLL---------ANNEKNAA 420
            .:            |.|...||.       |:..|:........:.:|         ..::||..
pombe   495 TKTLPSIGKKPIPLLDPNPISSTPISITFWVIMFLSVSFTIVTFFSILRIRSSEVRPLKSQKNTV 559

  Fly   421 DIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVHQILIVIVLGM 485
            .|..:.|..      .:|..|....|     :.:.:...:..|| .....|.:.:|.|.::...:
pombe   560 SINNKIDTS------KRRRKGKRRKR-----VSDEHSASSNFNE-IESQASFEQNQTLDILSENI 612

  Fly   486 IALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNANAEDLVDLGNGQVRVGKISFST 550
            :           |:|.:|.:.      .|...:.|..|:...|.   ::...:|.|.|..::...
pombe   613 V-----------EIQDKSTDP------LQKSLDSSLKSHLPEAT---VIQNTDGSVTVNSLTVYP 657

  Fly   551 NEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFR 615
             ||:|.|..||.|::|.:|:|.|||||:|.|.:..|.||:.||::||.|.|:|||:|.::..||.
pombe   658 -EVIGYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFL 721

  Fly   616 YIAVELCAATLQDYTEGDRSL-ELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPD 679
            ||.:|||...|.|..|...:. :|...||:..:|.|.|.|:|||||||:||||:||||:|:.:.:
pombe   722 YIVIELCKCNLSDLIEKPIAYDDLFKSIDLVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNN 786

  Fly   680 ----AKGKVRVMISDFGLCKKLNFGKTSFSRRS-GVTGTDGWIAPEMM----------------- 722
                :|.:||.:||||||.|||:|.::|....: ...|:.||.:||::
pombe   787 SPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPEILSGSLSQQSKEIQVKTRE 851

  Fly   723 -RSQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAE 786
             |.::.:.|.|||:|||::||.|:||.|.||.:...:.|||...|.|..|:...:..    :||.
pombe   852 GRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILKGNYCLVHLQSLGECG----VLAA 912

  Fly   787 QLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDR--VEKLQFHAEPLKSLEKNGRIV 849
            .||.|||..:|..||....:.|||||||..|.|.||.|||||  ||:....:..|:.||.|.:.|
pombe   913 DLIEDMIAFEPSKRPTIEVVLNHPLFWDYAKKLDFLIDVSDRFEVEERDPPSPLLQMLENNSKSV 977

  Fly   850 VLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWV 914
            :.::|...|...:.|:|.|||.|.|:.:.|:||.||||:|||.:|..:.:::||.:|..||:|:|
pombe   978 IGENWTTCLHSSLVDNLGKYRKYDGSKILDILRVLRNKRHHYQDLPESVRRVLGDLPDGFTSYFV 1042

  Fly   915 DRFPQLISHAYHAF-SICSNEPIFKPY 940
            ::||.|:.|.||.. .:...|..||.|
pombe  1043 EKFPMLLLHCYHLVKDVLYEESQFKRY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	65/374 (17%)
		STKc_IRE1	545..813	CDD:270884	118/291 (41%)
		S_TKc	552..812	CDD:214567	117/283 (41%)
		RNase_Ire1	817..941	CDD:199217	53/127 (42%)
ire1	NP_593384.1	Luminal_IRE1_like	82..440	CDD:276097	66/383 (17%)
		STKc_IRE1	652..939	CDD:270884	118/291 (41%)
		S_TKc	658..938	CDD:214567	117/283 (41%)
		RNase_Ire1	942..1070	CDD:199217	53/128 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	215	1.000	Domainoid score	I585
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I480
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		oto100842
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
TreeFam	1	0.960	-	-
	12	11.850