DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and Rnasel

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_036012.1	Gene:	Rnasel / 24014	MGIID:	1098272	Length:	735	Species:	Mus musculus

Alignment Length:	854	Identity:	173/854 - (20%)
Similarity:	311/854 - (36%)	Gaps:	236/854 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 VMMYDSLAKNKDAK----PWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQ--IVTLDRKHGKF 252
            |.:...|.|..||.    .|..|.. :|||.|                  |:  ||.|...||..
Mouse    39 VRVQQLLEKGADANACEDTWGWTPL-HNAVQA------------------GRVDIVNLLLSHGAD 84

  Fly   253 LWQR--DLSSPVVAAFLLGPDGLLSVPFTTVSD------EAYQAILEESKTGNVNTVK-LFQSLY 308
            ..:|  :.::|.:.|.:.|...||.:..:..:|      ..:.|.:|.::.||...:: ||..
Mouse    85 PHRRKKNGATPFIIAGIQGDVKLLEILLSCGADVNECDENGFTAFMEAAERGNAEALRFLFAK-- 147

  Fly   309 VGEH---------------QKGLYALPSLVDKNTPRISTAPPIKLLDGPTGDQNSNQETDPRTIY 358
             |.:               |.|..||.|..:|....:     :::|......:...::...|...
Mouse   148 -GANVNLRRQTTKDKRRLKQGGATALMSAAEKGHLEV-----LRILLNDMKAEVDARDNMGRNAL 206

  Fly   359 INDVL-------QEHAGIMLGH---YNMPNE-GNGNLQLSPTTASSKVVQSLATIHNYNDGYGLL 412
            |..:|       :|...|::.|   .|:..| |...|..:.....:.:||.|.:    .:|..:.
Mouse   207 IRTLLNWDCENVEEITSILIQHGADVNVRGERGKTPLIAAVERKHTGLVQMLLS----REGINID 267

  Fly   413 ANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINEWFMEHPSGKVHQI 477
            |.:.:....:.:..|.:|.||             .:.::.:.::|....:  |.... :...|
Mouse   268 ARDNEGKTALLIAVDKQLKEI-------------VQLLLEKGADKCDDLV--WIARR-NHDYH-- 314

  Fly   478 LIVIVLGMIALFWYTCSTMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNANAEDLVDLGNGQVR 542
            |:.::|..:|              ..:........:.:.|...|.....::....::    |:::
Mouse   315 LVKLLLPYVA--------------NPDTDPPAGDWSPHSSRWGTALKSLHSMTRPMI----GKLK 361

  Fly   543 VGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFC 607
            :    |..::....|.....|:.|.::.|.|||| :..|......:||:.||:...|.|:|.::.
Mouse   362 I----FIHDDYKIAGTSEGAVYLGIYDNREVAVK-VFRENSPRGCKEVSCLRDCGDHSNLVAFYG 421

  Fly   608 TEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVW--QVLSQAASGLSHLHSLDIVHRDIKP 670
            .|.|:...|:.|.||..||:::....|...::|..|.:  .:|.....|:..||.....|:|::|
Mouse   422 REDDKGCLYVCVSLCEWTLEEFLRLPREEPVENGEDKFAHSILLSIFEGVQKLHLHGYSHQDLQP 486

  Fly   671 QNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTTTAVDIFS 735
            ||:||   |:|..||  ::||....:. .|::...||                        |:..
Mouse   487 QNILI---DSKKAVR--LADFDQSIRW-MGESQMVRR------------------------DLED 521

  Fly   736 LGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSR 800
            ||.:..||:..|...| :.||.|     ::..|..:.|:::::|    |...|.|
Mouse   522 LGRLVLYVVMKGEIPF-ETLKTQ-----NDEVLLTMSPDEETKD----LIHCLFS---------- 566

  Fly   801 PPARCIGN-------HPLFWDEPKMLSFLQDV------------SDRVEKLQFHA-EPLKSLEKN 845
             |...:.|       ||.||........|::|            ||.:..||... ||.:|
Mouse   567 -PGENVKNCLVDLLGHPFFWTWENRYRTLRNVGNESDIKVRKCKSDLLRLLQHQTLEPPRS---- 626

  Fly   846 GRIVVLDDWNVHLDPMITDDL------RKYRGYMGASVRDLLRALRNKKHHYHELTPAAQK-MLG 903
                 .|.|...:|..:.|::      ||...|.. :|.|||:.:||...|.:|......| :||
Mouse   627 -----FDQWTSKIDKNVMDEMNHFYEKRKKNPYQD-TVGDLLKFIRNIGEHINEEKKRGMKEILG 685

  Fly   904 CIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPK 968
                :.:.|:.:.||.|:.:.|...    .|..::.::                         |:
Mouse   686 ----DPSRYFQETFPDLVIYIYKKL----KETEYRKHF-------------------------PQ 717

  Fly   969 PLPKIGSPK 977
            |.|::..|:
Mouse   718 PPPRLSVPE 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	35/156 (22%)
		STKc_IRE1	545..813	CDD:270884	68/276 (25%)
		S_TKc	552..812	CDD:214567	67/268 (25%)
		RNase_Ire1	817..941	CDD:199217	33/143 (23%)
Rnasel	NP_036012.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		ANK repeat	24..55	CDD:293786	5/15 (33%)
		ANK 1	24..53		5/13 (38%)
		Binding to TMEV Leader protein. /evidence=ECO:0000269\|PubMed:29652922	26..51		3/11 (27%)
		Ank_2	<29..88	CDD:403870	17/67 (25%)
		ANK 2	58..87		12/47 (26%)
		ANK repeat	59..89	CDD:293786	11/48 (23%)
		Ank_2	61..>298	CDD:423045	51/280 (18%)
		ANK repeat	91..122	CDD:293786	6/30 (20%)
		ANK 3	91..120		6/28 (21%)
		ANK repeat	124..154	CDD:293786	7/32 (22%)
		ANK 4	124..153		7/31 (23%)
		ANK repeat	167..199	CDD:293786	6/36 (17%)
		ANK 5	167..197		6/34 (18%)
		ANK 6	201..234		6/32 (19%)
		2-5A binding (P-loop) 1	229..242		3/12 (25%)
		ANK repeat	238..270	CDD:293786	7/35 (20%)
		ANK 7	238..268		6/33 (18%)
		2-5A binding (P-loop) 2	253..275		5/25 (20%)
		ANK 8	272..301		5/41 (12%)
		ANK repeat	272..297	CDD:293786	4/37 (11%)
		ANK 9	303..328		5/43 (12%)
		PKc_like	361..585	CDD:419665	68/279 (24%)
		RNase_RNase-L	588..707	CDD:199218	32/136 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..735		4/38 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810