DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and ERN1

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	XP_016879836.1	Gene:	ERN1 / 2081	HGNCID:	3449	Length:	1014	Species:	Homo sapiens

Alignment Length:	1028	Identity:	393/1028 - (38%)
Similarity:	556/1028 - (54%)	Gaps:	192/1028 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGS-- 115
            |.|:..|||.|.|.|:...|..|:||:.:||  |.:...:|:.|.|||||.|||:|.||...:
Human    67 ETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP--VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEG 129

  Fly   116 LKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVM--GFGDATVDGKEGEQIG 178
            |.|||:|||:||..:||||||||||.|||.|.||::|..||.:::.:  .|.|:..
Human   130 LTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLC--------- 185

  Fly   179 WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIV 243
             .::..:|||||:||:.|||:  |.::.: ||.|::||.|  :.||...:|:..|..:..:|.:|
Human   186 -PSTSLLYLGRTEYTITMYDT--KTRELR-WNATYFDYAA--SLPEDDVDYKMSHFVSNGDGLVV 244

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTV------- 301
            |:|.:.|..||.::.:|||||.::...:||..|....|:.|..:.:...|  |.|..:
Human   245 TVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMS--GEVGRITKWKYPF 307

  Fly   302 --------KLFQSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGP------TGDQ--- 346
                    ||..:||||::...|||.||:|.:.   .||.||.|   ||:||      .||:
Human   308 PKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLP---LLEGPQTDGVTIGDKGEC 369

  Fly   347 ----NSNQETDP------RTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLAT 401
                :::.:.||      :..|:.:.     .:::||:.           :|.:||:|:::....
Human   370 VITPSTDVKFDPGLKSKNKLNYLRNY-----WLLIGHHE-----------TPLSASTKMLERFPN 418

  Fly   402 ---IHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFIN 463
               .|..|   .:.|::||.:.:       |::.: :||     |.....|.:.::..:..|..
Human   419 NLPKHREN---VIPADSEKKSFE-------EVINL-VDQ-----TSENAPTTVSRDVEEKPAHA- 466

  Fly   464 EWFMEHPSGKVHQIL---------IVIVLGMIA-LFWYTCST-----------MRELQK------ 501
               ...|...|..:|         ..:::|.:| :..|..|.           .:||:|
Human   467 ---PARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQ 528

  Fly   502 --------------------------QSENGSKTFAIAQNGSNGS--TGSNGSNANAEDLVDLGN 538
                                      ...:|:.:.:.:...||.|  :||:.|.|.:...::..:
Human   529 QQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDD 593

  Fly   539 GQ-----VRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDA 598
            |.     |.||||||...:|||.|.|||.|::|.|:.|.|||||:|||||:||||||.||||||.
Human   594 GDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDE 658

  Fly   599 HENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDI 663
            |.||:||||||:||||:|||:||||||||:|.|......|  .::...:|.|..|||:|||||:|
Human   659 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLQQTTSGLAHLHSLNI 721

  Fly   664 VHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---SQ 725
            ||||:||.|:|||:|:|.||::.|||||||||||..|:.||||||||.||:|||||||:.   .:
Human   722 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE 786

  Fly   726 RTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLIS 790
            ..|..|||||.|||:|||:|.|.|.||.:|:||||||....:|..|.||...:    ::|.:||.
Human   787 NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHED----VIARELIE 847

  Fly   791 DMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWN 855
            .||..|||.||.|:.:..||.||...|.|.|.||||||:||.......:|.||:.||.||..||.
Human   848 KMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWR 912

  Fly   856 VHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQL 920
            .::...:..||||:|.|.|.||||||||:|||||||.||....::.||.:|.:|..|:..|||.|
Human   913 ENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHL 977

  Fly   921 ISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKI 973
            ::|.|.|..:||:|.:|:|||     |..|                |:|.|.:
Human   978 LAHTYRAMELCSHERLFQPYY-----FHEP----------------PEPQPPV 1009

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	108/286 (38%)
		STKc_IRE1	545..813	CDD:270884	159/270 (59%)
		S_TKc	552..812	CDD:214567	155/262 (59%)
		RNase_Ire1	817..941	CDD:199217	61/123 (50%)
ERN1	XP_016879836.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	308	1.000	Domainoid score	I1345
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55580
Inparanoid	1	1.050	651	1.000	Inparanoid score	I791
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	O	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870