DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and ire-1

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001254135.1	Gene:	ire-1 / 174305	WormBaseID:	WBGene00002147	Length:	967	Species:	Caenorhabditis elegans

Alignment Length:	1052	Identity:	377/1052 - (35%)
Similarity:	554/1052 - (52%)	Gaps:	152/1052 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LFLLASGLIASATAKSQQGDSAEVVSSGED-EKTDCTDLARDEEALMVFSTLGGGLTAIDPVTSE 74
            :|||   |.:|....|..|...:..|.|:| |||..|         ::.||:.|.|.|:|..|.|
Worm    11 IFLL---LFSSVICISTPGFRNDHESIGDDEEKTSST---------ILVSTIDGRLRALDSETGE 63

  Fly    75 IRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGSLKKLPYTIPQLVANAPCRSSDGIL 139
            |:||:.:: |::.......|...|||:|.|||:|.| :..||||||:.|||||..:||:.:||||
Worm    64 IKWTLQEE-PVLRSPSAVKQGFTFLPNPLDGSLYVL-KNSSLKKLPFNIPQLVHASPCKGNDGIL 126

  Fly   140 YSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGWATSR-AIYLGRTQYTVMMYDSLAKN 203
            |:|.|.|.|:.:|||||.:.:       |:.....::|..|..: .|:||||:|.|.|:|.  ||
Worm   127 YAGSKKDVWFGIDPKTGLKVE-------TLSSASADRICPANQKQTIFLGRTEYRVSMFDE--KN 182

  Fly   204 KDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLL 268
            : .|.||.||.||:|...|.  ...:.:.|..::::|.|:|.||:.|:..|::||..||||.:||
Worm   183 R-GKTWNATFNDYSAHLLPE--VNTWPFKHYASSSHGYILTFDRETGEMRWEQDLKQPVVALYLL 244

  Fly   269 GPDGLLSVPFTTVSDEAYQAILEESKTGN-------VN---------TVKLFQSLYVGEHQKGLY 317
            ..|||..:||..:..|..:.:.:...|.:       ||         |.:.|.:|:|||...|||
Worm   245 RDDGLHKLPFEVMGKETMENVAKNIFTVDQWPTVLGVNAADPQTTSLTNQFFPALFVGESSFGLY 309

  Fly   318 ALPSLVDKNT----PRISTAPPIKLLDGPT----GDQNSNQETDPRTIYINDV-------LQEHA 367
            |:.:|||..|    |:: ..||  ||:||.    .:....:...||...|.::       ..:..
Worm   310 AIEALVDHQTITYSPKL-LGPP--LLEGPAPIALTEMEKEEYLPPRRPIIRNIPPSITHKTSDGE 371

  Fly   368 GIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLATIHNYNDGYGLLANNEKNAADIGVQTDPELVE 432
            .::||:::.|                  :.::|||                        .|....
Worm   372 YLLLGYHDRP------------------MMTMATI------------------------IPTRYP 394

  Fly   433 IGIDQRTNGNTINRTKTIIL----QNSNKVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTC 493
            :....:..|:||.|....:|    ...::..:||......||. ..:..|:.:...::.:.| .|
Worm   395 VPGPHKAIGSTIERPPPQLLGPVEPQKHEDTSFILLLLNNHPI-PFYATLVTMFALLLTVIW-QC 457

  Fly   494 STMRELQKQSENGSKTFAIAQNGSNGSTGSNGSNAN------AEDLVDLGNGQVRVG-KISFSTN 551
            ....:.|| |.:...:|.|..|.....:......:|      |...:::..|.:.|| |:.:|.:
Worm   458 GRQWDQQK-STSRMDSFEIVNNPGESRSAQTSKQSNRGSFGWANRKIEIPEGWMAVGSKLMYSPS 521

  Fly   552 EVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRY 616
            ::||.|||||.|::|||:.|.|||||::.|...||.||..||||||.|.:|:||||.|.|.||||
Worm   522 DILGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRY 586

  Fly   617 IAVELCAATLQDYTEGDRSLELQNHIDV--WQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPD 679
            :|:|||.|:|.||.|   ..|:|.::.:  ..::.||..||:|||:..|||||:|||||||::..
Worm   587 LALELCIASLNDYVE---QKEVQQNVTIALRDIMKQATDGLAHLHASKIVHRDMKPQNVLITMAS 648

  Fly   680 AKGKVRVMISDFGLCKKLNFGKTSFSR--RSGVTGTDGWIAPEMMRSQRTTTAVDIFSLGCVYYY 742
            .:|::|.:||||||||::..||.|.||  .||:.|||||||||::.|..|:..||||||||::||
Worm   649 QRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYY 713

  Fly   743 VLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIG 807
            ||:.|.|.||.:|.|||||::.||.|.||...||..     ||:.|||.|::.:|..|..|..:.
Worm   714 VLTSGTHPFGKSLHRQANIVNGEYTLNKLADLDDWS-----LADDLISSMLNVEPLHRLTADAVL 773

  Fly   808 NHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGY 872
            |||.||...|.|::..||||||||.:.::..::.:|.:.||||...|...:...:.:||||:|.|
Worm   774 NHPFFWTSEKRLAYFSDVSDRVEKEEDNSPVVRRIETDARIVVCGGWREKICDALKEDLRKFRTY 838

  Fly   873 MGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIF 937
            ...||||||||:|||||||.||....::.||.||.:|.:|:..|||:|:.|.|.|...||.|.:|
Worm   839 KSFSVRDLLRAMRNKKHHYRELPEDVRQSLGDIPDQFLHYFTSRFPRLLLHVYKATEYCSGEAVF 903

  Fly   938 KPYYSAGYLFTRPWYFDADDA---LFPMLMLDPKPLPKIGSP------KKTPSPASSQAQQLKQR 993
            |.|||             ||.   ::|::..:.:...||...      .:.|.|...:......:
Worm   904 KRYYS-------------DDVRARMYPIVEEEERVRKKIKEEMANEVWARAPKPVEQRTPLKLDK 955

  Fly   994 KGLYNFRKPNDE 1005
            :.:.....||.:
Worm   956 RNIKKKSNPNTD 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	107/284 (38%)
		STKc_IRE1	545..813	CDD:270884	141/271 (52%)
		S_TKc	552..812	CDD:214567	139/263 (53%)
		RNase_Ire1	817..941	CDD:199217	57/123 (46%)
ire-1	NP_001254135.1	Luminal_IRE1	42..311	CDD:188875	107/291 (37%)
		PQQ_2	44..232	CDD:290097	81/210 (39%)
		PKc_like	515..779	CDD:304357	141/271 (52%)
		S_TKc	518..778	CDD:214567	140/267 (52%)
		RNase_Ire1	782..907	CDD:199217	57/124 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167220
Domainoid	1	1.000	272	1.000	Domainoid score	I951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55580
Inparanoid	1	1.050	576	1.000	Inparanoid score	I558
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		oto17185
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940