Protein Alignment Ire1 and ire-1

DIOPT Version :10

• Sequence 1: NP_001097839.1
• Gene: Ire1 / 42358
• FlyBaseID: FBgn0261984
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_001254135.1
• Gene: ire-1 / 174305
• WormBaseID: WBGene00002147
• Length: 967
• Species: Caenorhabditis elegans
• Alignment Length: 487
• Identity: 91/487 - (18%)
• Similarity: 160/487 - (32%)
• Gaps: 157/487 - (32%)

  Fly   176 ELSRIQKEMHSTQKGVDTLASVEQKLNAHVNGCYNISEAQAIMEEVKK--IQKSLITGEREKKEL 238
            |||...|:....|:..::.....:......:|.|:.::....:.::..  |.:||:....||::.
 Worm    27 ELSLKDKDKKIKQQPANSSNPSSETFRPSGSGKYDFAKKYRSIRDLSSSLIGESLLDSSSEKEQG 91

  Fly   239 MKSLAQVKDDLTRLQLRQESPDASTFNLAQDRICAASQTDLSSEHFPMGAREMAKMR-QRYDEWR 302
            .:...|.|                 ||.|.|  |.:....||........|.||.:: :||
 Worm    92 NEFFKQKK-----------------FNEAID--CYSRSIALSPNAVTYANRAMAYLKIKRY---- 133

  Fly   303 RRVKEIQEQLAALEEKIRPGELESDQDRLLLFQEKKQLLLEYRSITPKSRSPTEMRRIQSVCRQL 367
                             |..|::..:          .|.|:.|.|...||..|..:.: .:.::.
 Worm   134 -----------------REAEVDCTE----------ALNLDDRYIKAYSRRATARKEL-GMIKEA 170

  Fly   368 EEDLNMAYEESNQCIANRLKLHEEKQALLQQLLEALKEFTHLEHQLKSLSASTLSISSSSSLGSL 432
            :||...|           |:|..|.|.|.:|..:           :|||....:...::.::  .
 Worm   171 KEDAEFA-----------LRLEPESQELKKQYAD-----------IKSLLEKEIIEKATGAM--Q 211

  Fly   433 STASSKGSLSGLSFTDIYGDPLSAEPQIDMVDMNRRVQRLFHPSSEVTSLSPRSSLSTETPPVSP 497
            |||......|||                     ::::|:   |.:|:||........|....|.|
 Worm   212 STAQELLKTSGL---------------------DKKIQK---PKTEMTSKPVTLVAKTNRDIVQP 252

  Fly   498 MKMDWVAVVTAAAAVAGGSDSPSANPASVHAAINTTAKLASAASGPSYATPGTSQPVVPSYAVAT 562
                          |.|.::|             :..||.........:..|:.:  :|:   .|
 Worm   253 --------------VLGSNES-------------SGKKLIENIQPEEKSKEGSMK--IPA---IT 285

  Fly   563 GVASSASSTTTSTEYN-----LDRQRLEEQLQELKI-RQLGIAGGPLSPIYEKPSYLEPAALLSR 621
            .:..|...|..|..|.     .||...:....|.:: :||.:          |||..|.||..:.
 Worm   286 EILDSKKVTPGSQSYEKEAKPSDRNGTQPSGPENQVSKQLEL----------KPSVQELAAHAAS 340

  Fly   622 SSSTSNTRSVSTTVSD-------ESVAGDSGV 646
            .:.|..::::.|..|.       .|.:|||.:
 Worm   341 LAMTEASKNIKTPKSAYEFENSWRSFSGDSAL 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	26/147 (18%)
		STKc_IRE1	545..813	CDD:270884	25/115 (22%)
		RNase_Ire1	817..941	CDD:199217
ire-1	NP_001254135.1	Luminal_IRE1	42..311	CDD:188875	70/399 (18%)
		Protein Kinases, catalytic domain	515..779	CDD:473864
		RNase_Ire1	782..907	CDD:199217