DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and ERN2

DIOPT Version :9

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_150296.4	Gene:	ERN2 / 10595	HGNCID:	16942	Length:	926	Species:	Homo sapiens

Alignment Length:	971	Identity:	376/971 - (38%)
Similarity:	510/971 - (52%)	Gaps:	162/971 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLG---QMG 114
            |.|::.|||.|.|.|:...|.:::||:.|||  |.|....|....||.||.|||:|.||   |.|
Human    38 ENLLLVSTLDGSLHALSKQTGDLKWTLRDDP--VIEGPMYVTEMAFLSDPADGSLYILGTQKQQG 100

  Fly   115 SLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGW 179
             |.|||:|||:||..:|||||||:.|:|:|.|.|::|||::|..:..:     |.:|.
Human   101 -LMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTL-----TTEGP------- 152

  Fly   180 ATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYI-HLTTTTNGQIV 243
            :|.| :|:|||||||.|:|..|   .|..||.|:..|   ||||......:|: ||.:...|.::
Human   153 STPR-LYIGRTQYTVTMHDPRA---PALRWNTTYRRY---SAPPMDGSPGKYMSHLASCGMGLLL 210

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAI------LEESKTGNVNTVK 302
            |:|...|..||.:||..||:..:....|||..:|..|::.:....:      :....:|..:|..
Human   211 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTAT 275

  Fly   303 LF--------QSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGPTGDQ-----NSNQE 351
            ||        .:||||:.:.|.|...:||...   .||..|..|   .||||.|:     :..:|
Human   276 LFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAP---ADGPTTDEVTLQVSGERE 337

  Fly   352 TDPRTIY---INDVLQEHAGIMLGHYNMPNEGNGN-LQLSPTTASSKVVQSLATIHNYNDGYGLL 412
            ..|.|..   ...|......:::||:.:|...:.. |::.||..|..
Human   338 GSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGT------------------ 384

  Fly   413 ANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINE---------WFME 468
                       .:|.|                        ..:.:..||..|         |..|
Human   385 -----------AETRP------------------------PENTQAPAFFLELLSLSREKLWDSE 414

  Fly   469 -HPSGKV--------HQILIVIVLGMIALFWYTCSTMRE-----LQKQSEN--GSKTFA-IAQNG 516
             ||..|.        .|.|:...|..:.|..:....||:     ::||.|.  ....|| |:|:.
Human   415 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDA 479

  Fly   517 SNGSTGSN--------GSNANAEDLVDLGNGQVR-VGKISFSTNEVLGKGCEGTFVFKGTFEERF 572
            .:..:|::        ..:..|:.|.|....|:. ||||||:..:|||:|..|||||:|.||.|.
Human   480 QSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRA 544

  Fly   573 VAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEG---DR 634
            |||||||.|||....|||.||:|||.|.||:||||||:..||.|||:|||.|:||:|.|.   ||
Human   545 VAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDR 609

  Fly   635 -SLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLN 698
             .||.:      .||.|..|||:|||||.|||||:||.|:||:.||::|..||::|||||||||.
Human   610 GGLEPE------VVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLP 668

  Fly   699 FGKTSFSRRSGVTGTDGWIAPEMMR---SQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQAN 760
            .|:.|||..||:.||:||:|||:::   ....|:||||||.|||:|||||||.|.|||:|.||||
Human   669 AGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQAN 733

  Fly   761 ILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDV 825
            ||:....||.|  |::..|.  ::|..|:..|:...||.||.|..:..||.||...|.|.|.|||
Human   734 ILTGAPCLAHL--EEEVHDK--VVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDV 794

  Fly   826 SDRVEKLQFHAEPL-KSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKH 889
            ||.:|| :...||| ::||..|..||.|:|:.|:...:..||||:|.|.|.||||||||:|||||
Human   795 SDWLEK-ESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKH 858

  Fly   890 HYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRP 950
            ||.||....::.||.:|..|..|:.:|||:|:.|.:.|...|::|.:|.|||.......||
Human   859 HYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRP 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	106/285 (37%)
		STKc_IRE1	545..813	CDD:270884	152/274 (55%)
		S_TKc	552..812	CDD:214567	148/266 (56%)
		RNase_Ire1	817..941	CDD:199217	60/124 (48%)
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	123/352 (35%)
		PQQ	<41..237	CDD:224437	89/217 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	478..509		4/30 (13%)
		STKc_IRE1	517..782	CDD:270884	152/274 (55%)
		S_TKc	520..781	CDD:214567	149/270 (55%)
		RNase_Ire1	785..910	CDD:199217	60/125 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141589
Domainoid	1	1.000	308	1.000	Domainoid score	I1345
eggNOG	1	0.900	-	-		E2759_KOG1027
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	651	1.000	Inparanoid score	I791
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48078
OrthoDB	1	1.010	-	-		D1019877at2759
OrthoFinder	1	1.000	-	-		FOG0001857
OrthoInspector	1	1.000	-	-		oto89158
orthoMCL	1	0.900	-	-		OOG6_102150
Panther	1	1.100	-	-	LDO	PTHR13954
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2163
SonicParanoid	1	1.000	-	-		X1217
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800