Protein Alignment MICU3 and micu3a

DIOPT Version :10

• Sequence 1: NP_001262741.1
• Gene: MICU3 / 42357
• FlyBaseID: FBgn0038735
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: XP_068077159.1
• Gene: micu3a / 559552
• ZFINID: ZDB-GENE-070713-1
• Length: 493
• Species: Danio rerio
• Alignment Length: 517
• Identity: 217/517 - (41%)
• Similarity: 299/517 - (57%)
• Gaps: 76/517 - (14%)

  Fly     4 LAARLTV-------KNCTIIAQRSSVIVGVGRSAR---FSSSSSQMGRIPGHKTRRLLTIVGGSA 58
            ||||..:       |.||    |:.:.|.||.:|.   .....|:|....|.|.....|:.....
Zfish    16 LAARNALFRSPVKDKRCT----RTGLAVAVGVAAGGAVLYYYYSEMCGFGGRKAPINRTVCRALL 76

  Fly    59 VSLAALAAFIKLRSAENPVNAVSLKRRMRDDSELENVKLTARERRFIKFASVEYDDQLYMTPQDF 123
            .||.|:||     ..:.||          .|.:..:|.:::.|.||..|:||||:.|||||||:|
Zfish    77 PSLPAVAA-----KEKAPV----------FDFDETDVYMSSHEHRFRLFSSVEYEGQLYMTPQNF 126

  Fly   124 LDSVVEQEPRPRLKRRQLSSDEVDKYKENTPALKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKP 188
            ::||...|||.:...|.|:..|::|...:||.:.||:::||||||::||::||||||||.|||||
Zfish   127 IESVTMSEPRIKKPWRSLTKQELEKILSDTPPVWKGTSKLFRNLRERGIIAYTEYLFLLCILTKP 191

  Fly   189 KSGFRIAFNMFDTDGNQRVDKDEFLVIISIL------AGALKDTQNVDPQTKRILSRLVSYD--- 244
            .:||:|||||||.||||.|||.||:|:..|.      .|...|.:    ::.::..:|..|.
Zfish   192 HAGFKIAFNMFDADGNQMVDKREFMVLQEIFRKKNEKKGRKGDAE----KSAQLSMQLYGYQVAP 252

  Fly   245 ------EQSQMTKPMAV-PQAKRGIMERIFSGAWKEKHGEQEPEEELATPTPLEQNYVNDGEGLQ 302
                  ::||...|.:. .:.:||..:.:||              :||....||:        ..
Zfish   253 VNSVLKKESQEFVPRSYWDKLRRGASQALFS--------------DLAEDFKLER--------AD 295

  Fly   303 RRHMVATTLQLHFFGKRGTGVINYDNFYRFMDNLQTEVLELEFHEFSKGNSVISELDFAKILLRY 367
            ...|:.|||.:|||||:|...:.:|:|||||||||||:||:||..:|||.:.|||.|||:|||||
Zfish   296 ENMMIDTTLLVHFFGKKGKAELTFDDFYRFMDNLQTEMLEIEFLTYSKGMTTISEEDFARILLRY 360

  Fly   368 TYLATDEYDVFLERLLERVKDEKGISFHDFRDFCHFLNNLDDFTIAMRMYTLADRAISKDEFSRA 432
            |.:  ::...:||.:.:.:.|||||:|.:||.|..|||||:||.|||:||..|.|:|.:|||:||
Zfish   361 TNV--EDIRSYLENVRQCIPDEKGITFEEFRSFFQFLNNLEDFAIAMQMYNFACRSIGQDEFARA 423

  Fly   433 VKICTGYKLSPHLIDTVFAIFDADGDGLLSYKEFIAIMKDRLH---RGFKVSGRFFDYNEAL 491
            |.:.||.||:.||::|:|.|||.|.|..|||||||.|||||||   ||:|...||..:...|
Zfish   424 VYVATGLKLTRHLVNTIFKIFDVDHDDQLSYKEFIGIMKDRLHRGGRGYKSVERFTSFRSCL 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EFh_MICU	191..474	CDD:333716	132/298 (44%)
		EF-hand motif	191..220	CDD:320080	20/34 (59%)
		EF-hand motif	310..340	CDD:320080	19/29 (66%)
		EF-hand motif	408..437	CDD:320080	16/28 (57%)
		EF-hand motif	445..474	CDD:320080	19/28 (68%)
micu3a	XP_068077159.1	EFh_MICU3	194..465	CDD:320083	132/298 (44%)
		EF-hand motif	194..223	CDD:320083	20/28 (71%)
		EF-hand motif	303..333	CDD:320083	19/29 (66%)
		EF-hand motif	399..428	CDD:320083	16/28 (57%)
		EF-hand motif	436..465	CDD:320083	19/28 (68%)