DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU3 and Micu1

DIOPT Version :9

Sequence 1:	NP_001262741.1	Gene:	MICU3 / 42357	FlyBaseID:	FBgn0038735	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006256482.1	Gene:	Micu1 / 365567	RGDID:	735033	Length:	483	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	133/524 - (25%)
Similarity:	226/524 - (43%)	Gaps:	142/524 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SVIVGVGRSARFSSSSSQMGRIPGHKTRRLLTI--VGGSAVSLAALAAFIKLRSAENPVNAVSLK 83
            |.:..:...:|:...:||    |....|||:.:  :|.|||: |:.....|...||:|.:..|.|
  Rat     8 SALAELAMGSRWYHGTSQ----PTQTKRRLMLVAFLGASAVT-ASTGLLWKKAHAESPPSVNSKK 67

  Fly    84 R------RMRDDSELENVKLTA-------------------RERR-----------------FIK 106
            .      :.:|..|:.:.:.:|                   |:|:                 |..
  Rat    68 TDAGDKGKSKDTREVSSHEGSAADTAAEPYPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRY 132

  Fly   107 FASVEY-----DDQLYMTPQDFLDSVVEQEPRPR--------LKR--------RQLSSDEVDKYK 150
            ||:::.     :.:::||||||:.|:...|.:|.        :||        .:..:.|.:|:.
  Rat   133 FATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKEFWQTEKIAQEREKFA 197

  Fly   151 ENTPALKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGFRIAFNMFDTDGNQRVDKDEFLVI 215
            :      :||  :|..|.:.|::|:::|:||.::|:.|:..|.|||.|||.:|:..||.:||..:
  Rat   198 D------EGS--IFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQV 254

  Fly   216 ISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQAKRGIMERIFSGAWKEKHGEQEP 280
            .||:                          :||.:..|                    :|.::
  Rat   255 QSII--------------------------RSQTSMGM--------------------RHRDR-- 271

  Fly   281 EEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTGVINYDNFYRFMDNLQTEVLELEF 345
                    |...|.:..|        :.:.|..:|||....|.:...||..|...||.:||:|||
  Rat   272 --------PTTGNTLKSG--------LCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEF 320

  Fly   346 HEFSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLERVKDEKGISFHDFRDFCHFLNNLDDF 410
            ......:..|||..|..:||.|:.:.:.:......:|.:..||.||::|.:..:|..||.|::|.
  Rat   321 ERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDV 385

  Fly   411 TIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDTVFAIFDADGDGLLSYKEFIAIMKDRLH 475
            ..|:..|.:|..::.|....:..:.....:||.|:.|.|||:||.||:|.||.|||::|||.||.
  Rat   386 DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLM 450

  Fly   476 RGFK 479
            ||.:
  Rat   451 RGLE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EF-hand_7	421..470	CDD:290234	18/48 (38%)
MICU3	NP_001262741.1	EF-hand_8	424..473	CDD:290545	21/48 (44%)
Micu1	XP_006256482.1	Acyl-thio_N	<41..>85	CDD:289367	12/44 (27%)
Micu1	XP_006256482.1	EF-hand_5	231..254	CDD:289945	12/22 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820