DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MICU3 and Micu3

DIOPT Version :9

Sequence 1:	NP_001262741.1	Gene:	MICU3 / 42357	FlyBaseID:	FBgn0038735	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_006253262.1	Gene:	Micu3 / 364601	RGDID:	1563411	Length:	523	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	211/486 - (43%)
Similarity:	275/486 - (56%)	Gaps:	54/486 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GRSAR-FSSSSSQMGRIPGHKTRR-------LLTIVGGSAVSLAALAAFIKLRSAEN-------- 75
            |.|.| ||......|.:.....||       :....||..|.|.....:...|:..:
  Rat    37 GMSGRPFSGREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELVAPELD 101

  Fly    76 -----------PVNA----VSLKRRMRDDSELENVKLTARERRFIKFASVEYDDQLYMTPQDFLD 125
                       ||.|    |:..|.:.:|.:|   ..|:|||||..|||:|.:.||:|||.||:.
  Rat   102 ESPRGRGLLPIPVAAAKETVATGRAVTEDLDL---YATSRERRFRLFASIECEGQLFMTPYDFIL 163

  Fly   126 SVVEQEPRPRLKRRQLSSDEVDKYKENTPALKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKS 190
            :|...||:.....:.||..|:.:....||.:.|||::|||||:::|::|||||||||.|||||.:
  Rat   164 AVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLFLLCILTKPHA 228

  Fly   191 GFRIAFNMFDTDGNQRVDKDEFLVIISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAV 255
            ||||||||||||||:.|||.||||:..|.....:..:....:.||.:.||..|...|. |..:..
  Rat   229 GFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLYGYHSP-TNSVLK 292

  Fly   256 PQAKRGIMERIFSGAWK--EKHGEQEPEEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGK 318
            |.|:    |.:....|.  .:...|....:||.......:.|.|           |||.:|||||
  Rat   293 PDAE----ELVSRSYWDTLRRSTSQALFSDLAERADDITSLVAD-----------TTLLVHFFGK 342

  Fly   319 RGTGVINYDNFYRFMDNLQTEVLELEFHEFSKGNSVISELDFAKILLRYTYLATDEYDVFLERLL 383
            :|...:|:::||||||||||||||:||..:|.|.:.|||.|||.||||||.:  :...||||.:.
  Rat   343 KGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNV--ENTSVFLENVR 405

  Fly   384 ERVKDEKGISFHDFRDFCHFLNNLDDFTIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDT 448
            ..:.:||||:|.:||.|..|||||:||.||:.||..|.|:|.:|||.|||.:.||.||||||::|
  Rat   406 YSIPEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNT 470

  Fly   449 VFAIFDADGDGLLSYKEFIAIMKDRLHRGFK 479
            ||.|||.|.|..|||||||.||||||||||:
  Rat   471 VFKIFDVDKDDQLSYKEFIGIMKDRLHRGFR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EF-hand_7	421..470	CDD:290234	31/48 (65%)
MICU3	NP_001262741.1	EF-hand_8	424..473	CDD:290545	33/48 (69%)
Micu3	XP_006253262.1	EF-hand_8	442..495	CDD:290545	35/52 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345347
Domainoid	1	1.000	76	1.000	Domainoid score	I8800
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H15058
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2325
OMA	1	1.010	-	-		QHG45761
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	1	1.000	-	-		FOG0004781
OrthoInspector	1	1.000	-	-		oto98452
orthoMCL	1	0.900	-	-		OOG6_107718
Panther	1	1.100	-	-	LDO	PTHR12294
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3368
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770