DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU3 and Micu1

DIOPT Version :9

Sequence 1:	NP_001262741.1	Gene:	MICU3 / 42357	FlyBaseID:	FBgn0038735	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001278371.1	Gene:	Micu1 / 216001	MGIID:	2384909	Length:	483	Species:	Mus musculus

Alignment Length:	524	Identity:	135/524 - (25%)
Similarity:	227/524 - (43%)	Gaps:	142/524 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SVIVGVGRSARFSSSSSQMGRIPGHKTRRLLTI--VGGSAVSLAALAAFIKLRSAENP--VNA-- 79
            |.:..:...:|:...:||    |....|||:.:  :|.|||: |:.....|...||:|  ||:
Mouse     8 SALAELAVGSRWYHGASQ----PTQTKRRLMLVAFLGASAVT-ASTGLLWKKAHAESPPCVNSKK 67

  Fly    80 --VSLKRRMRDDSELENVKLTA-------------------RERR-----------------FIK 106
              ...|.|.:|..|:.:.:..|                   |:|:                 |..
Mouse    68 PDTEDKERNKDSGEVSSREGRAADAAAEPYPEDKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRY 132

  Fly   107 FASVEY-----DDQLYMTPQDFLDSVVEQEPRPR--------LKR--------RQLSSDEVDKYK 150
            ||:::.     :.:::||||||:.|:...|.:|.        :||        .:..:.|.:|:.
Mouse   133 FATLKVINEPGETEVFMTPQDFVRSITPNEKQPEHLGLDQYIIKRFDGKEFWQTEKIAQEREKFA 197

  Fly   151 ENTPALKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGFRIAFNMFDTDGNQRVDKDEFLVI 215
            :      :||  :|.:|.:.|::|:::|:||.::|:.|:..|.|||.|||.:|:..||.:||..:
Mouse   198 D------EGS--IFYSLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQV 254

  Fly   216 ISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQAKRGIMERIFSGAWKEKHGEQEP 280
            .||:                          :||.:..|                    :|.::
Mouse   255 QSII--------------------------RSQTSMGM--------------------RHRDR-- 271

  Fly   281 EEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTGVINYDNFYRFMDNLQTEVLELEF 345
                    |...|.:..|        :.:.|..:|||....|.:...||..|...||.:||:|||
Mouse   272 --------PTTGNTLKSG--------LCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEF 320

  Fly   346 HEFSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLERVKDEKGISFHDFRDFCHFLNNLDDF 410
            ......:..|||..|..:||.|:.:.:.:......:|.:..||.||::|.:..:|..||.|::|.
Mouse   321 ERHDPVDGRISERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKDGKGLTFQEVENFFTFLKNINDV 385

  Fly   411 TIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDTVFAIFDADGDGLLSYKEFIAIMKDRLH 475
            ..|:..|.:|..::.|....:..:.....:||.|:.|.|||:||.||:|.||.|||::|||.||.
Mouse   386 DTALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLM 450

  Fly   476 RGFK 479
            ||.:
Mouse   451 RGLE 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EF-hand_7	421..470	CDD:290234	18/48 (38%)
MICU3	NP_001262741.1	EF-hand_8	424..473	CDD:290545	21/48 (44%)
Micu1	NP_001278371.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..107		10/49 (20%)
		Polybasic region. /evidence=ECO:0000250\|UniProtKB:Q9BPX6	101..112		1/10 (10%)
		EF-hand_5	231..254	CDD:289945	12/22 (55%)
		C-helix region. /evidence=ECO:0000250\|UniProtKB:Q9BPX6	463..473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820