DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MICU3 and Micu2

DIOPT Version :9

Sequence 1:	NP_001262741.1	Gene:	MICU3 / 42357	FlyBaseID:	FBgn0038735	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_599223.2	Gene:	Micu2 / 171433	RGDID:	619739	Length:	431	Species:	Rattus norvegicus

Alignment Length:	468	Identity:	174/468 - (37%)
Similarity:	259/468 - (55%)	Gaps:	87/468 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GRSARFSSSSSQMGRIPGHKTRRLLTIVGGSAV----SLAALAAFIKLRSAENPVNAVSLKRRMR 87
            |||||.::.        |.:.||.|. .||.||    .|||..|.:.|..|....:...:|...|
  Rat     6 GRSARLAAW--------GERLRRGLA-AGGRAVPSRGPLAAAVAGVALAGAGAAWHHGRVKAAAR 61

  Fly    88 DD--------SELENV-KLTARERRFIKFASVEYDDQLYMTPQDFLDSVVEQEPRPRLKRRQLSS 143
            :.        ::|..: ||:.|::||::|:|:|:|.:.||||:|||.||:.:....:...::|:.
  Rat    62 ESTLTGLVQKNDLGPIEKLSLRKQRFMQFSSLEHDGEYYMTPRDFLFSVMFERMDRKTLVKKLAK 126

  Fly   144 DEVDKYKENTPALKKGSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGFRIAFNMFDTDGNQRVD 208
            .:::.........:.||| .||:|.|||::|||||||||:|||||.|||.:||.|.|.|||:.::
  Rat   127 KDIEDVLSGIQTARCGST-FFRDLGDKGVISYTEYLFLLTILTKPHSGFHVAFKMLDADGNEMIE 190

  Fly   209 KDEFLVIISILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQAKRGIMERIFSGAWKE 273
            :.||:                  :.::|:|:.                           .|....
  Rat   191 RKEFV------------------KLQKIISKQ---------------------------DGFKTV 210

  Fly   274 KHGEQEPEEELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTGVINYDNFYRFMDNLQT 338
            |..|.|.:|    ||      ||: .||.      ||||:.||||||...::|..|.|||:||||
  Rat   211 KTNEIEYQE----PT------VNE-PGLN------TTLQVRFFGKRGEKKLHYKEFRRFMENLQT 258

  Fly   339 EVLELEFHEFSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLERVKDEKGISFHDFRDFCHF 403
            ||.|:||.:||||.:.:.:.|||:.||.:|  .::..|::.:.:.|::...:.||..:|:.||||
  Rat   259 EVQEMEFLQFSKGLNFMRKEDFAEWLLFFT--NSENKDIYWKNVREKLSVGESISLDEFKSFCHF 321

  Fly   404 LNNLDDFTIAMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDTVFAIFDADGDGLLSYKEFIA 468
            ..:|:||.|||:|::||.|.:...||.||||:.||.:||.:|:||||.|||.|||..||:.||:.
  Rat   322 TTHLEDFAIAMQMFSLAHRPVRLAEFKRAVKVATGQELSNNLLDTVFKIFDLDGDECLSHGEFLG 386

  Fly   469 IMKDRLHRGFKVS 481
            ::|:|:|||..||
  Rat   387 VLKNRMHRGLWVS 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EF-hand_7	421..470	CDD:290234	26/48 (54%)
MICU3	NP_001262741.1	EF-hand_8	424..473	CDD:290545	26/48 (54%)
Micu2	NP_599223.2	EFh_MICU2	173..392	CDD:320082	103/282 (37%)
		EF-hand motif	173..202	CDD:320082	12/46 (26%)
		EF-hand motif	230..260	CDD:320082	18/29 (62%)
		EF-hand motif	326..355	CDD:320082	15/28 (54%)
		EF-hand motif	363..392	CDD:320082	16/28 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	170	1.000	Domainoid score	I3676
eggNOG	1	0.900	-	-		E1_KOG2643
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D425365at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12294
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880