Protein Alignment MICU3 and MICU1

DIOPT Version :10

• Sequence 1: NP_001262741.1
• Gene: MICU3 / 42357
• FlyBaseID: FBgn0038735
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001428147.1
• Gene: MICU1 / 10367
• HGNCID: 1530
• Length: 553
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 139/587 - (23%)
• Similarity: 230/587 - (39%)
• Gaps: 199/587 - (33%)

  Fly    21 SVIVGVGRSARFSSSSSQMGRIPGHKTRRLLTI--VGGSAVSLAALAAFIKLRSAENPVNAVSLK 83
            |.:..:...:|:....||    |....|||:.:  :|.|||: |:.....|...||:|....:||
Human     8 SALAELAVGSRWYHGGSQ----PIQIRRRLMMVAFLGASAVT-ASTGLLWKRAHAESPPCVDNLK 67

  Fly    84 R------RMRDDSELEN-VKLTA----------------RERR-----------------FIKFA 108
            .      :.:|:.::.| .|.||                |:|:                 |..||
Human    68 SDIGDKGKNKDEGDVCNHEKKTADLAPHPEEKKKKRSGFRDRKVMEYENRIRAYSTPDKIFRYFA 132

  Fly   109 SVEY-----DDQLYMTPQDFLDSVVEQEPRPR--------LKR---------RQLSS-------- 143
            :::.     :.:::|||:||:.|:...|.:|.        :||         ..|||
Human   133 TLKVISEPGEAEVFMTPEDFVRSITPNEKQPEHLGLDQYIIKRFDGKAGVQWHHLSSLQPPTPWF 197

  Fly   144 -----------------------------DEV-------DKYKE---NTPALKK----------- 158
                                         |.|       .:|.:   ..|.|:|
Human   198 KRFFCLSLLSSWDYRHTPPCPANFFIFSRDRVSPCWPGWSRYPDLMIRPPWLRKVLGLQKISQER 262

  Fly   159 ------GSTRLFRNLRDKGIVSYTEYLFLLSILTKPKSGFRIAFNMFDTDGNQRVDKDEFLVIIS 217
                  ||  :|..|.:.|::|:::|:||.::|:.|:..|.|||.|||.:|:..||.:||..:.|
Human   263 EKFADEGS--IFYTLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGDGEVDMEEFEQVQS 325

  Fly   218 ILAGALKDTQNVDPQTKRILSRLVSYDEQSQMTKPMAVPQAKRGIMERIFSGAWKEKHGEQEPEE 282
            |:                          :||.:..|                    :|.::
Human   326 II--------------------------RSQTSMGM--------------------RHRDR---- 340

  Fly   283 ELATPTPLEQNYVNDGEGLQRRHMVATTLQLHFFGKRGTGVINYDNFYRFMDNLQTEVLELEFHE 347
                  |...|.:..|        :.:.|..:|||....|.:...||..|...||.:||:|||..
Human   341 ------PTTGNTLKSG--------LCSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFER 391

  Fly   348 FSKGNSVISELDFAKILLRYTYLATDEYDVFLERLLERVKDEKGISFHDFRDFCHFLNNLDDFTI 412
            ....:..|:|..|..:||.|:.:.:.:......:|.:..|:.||::|.:..:|..||.|::|...
Human   392 HDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKHFKEGKGLTFQEVENFFTFLKNINDVDT 456

  Fly   413 AMRMYTLADRAISKDEFSRAVKICTGYKLSPHLIDTVFAIFDADGDGLLSYKEFIAIMKDRLHRG 477
            |:..|.:|..::.|....:..:.....:||.|:.|.|||:||.||:|.||.|||::|||.||.||
Human   457 ALSFYHMAGASLDKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSNKEFVSIMKQRLMRG 521

  Fly   478 FK 479
            .:
Human   522 LE 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MICU3	NP_001262741.1	EFh_MICU	191..474	CDD:333716	76/282 (27%)
		EF-hand motif	191..220	CDD:320080	14/28 (50%)
		EF-hand motif	310..340	CDD:320080	10/29 (34%)
		EF-hand motif	408..437	CDD:320080	5/28 (18%)
		EF-hand motif	445..474	CDD:320080	17/28 (61%)
MICU1	NP_001428147.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..106		5/37 (14%)
		Polybasic region. /evidence=ECO:0000269|PubMed:27099988	99..110		1/10 (10%)
		K/R-ring. /evidence=ECO:0000269|PubMed:32494073	126..129		0/2 (0%)