DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and CMR2

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_014736.1	Gene:	CMR2 / 854260	SGDID:	S000005619	Length:	1648	Species:	Saccharomyces cerevisiae

Alignment Length:	691	Identity:	130/691 - (18%)
Similarity:	230/691 - (33%)	Gaps:	238/691 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SIGKILFAFMRNHPNSICQISDTEGTALTNGEA------------ITFAIRIAQQLK-----AMG 76
            ||.:||...:.|:.|... .||...|.|.|..|            .:|...:|..||     .:.
Yeast   981 SILEILEWRISNYGNETA-FSDGTNTNLVNSSASNDNNVHKKVSWASFGKIVAGFLKKIVGSKIP 1044

  Fly    77 LKQDDVVGIVGTNTTYLMPVVLGCL---LNGTPFHAVSPWQDEDTIKHLFSIT---RPKLIFCD- 134
            ||..|.:.|:..|:...:.:::.||   |...|..:|.....|:.:|.|.:|.   :.|.:|.|
Yeast  1045 LKHGDPIIIMCENSVEYVAMIMACLYCNLLVIPLPSVKESVIEEDLKGLVNIIQSYKVKRVFVDA 1109

  Fly   135 ------------GKCFQR---------------------LSIIARILKSHVYTLKDHRLGM-PRV 165
                        .|||::                     :|:...:||.........|:|| |.|
Yeast  1110 KLHSLLNDNNVVNKCFKKYKSLIPKITVFSKVKTKNALTVSMFKNVLKQKFGAKPGTRIGMTPCV 1174

  Fly   166 -------------------EDLLEPTTAELYYVPETLLLGGDHTVAILCTSGTTGLP------KA 205
                               ..||..:.    .|.|||.|..:..:..:| |.|:||.      ..
Yeast  1175 VWVNTEYDVTSNIHVTMTHSSLLNASK----IVKETLQLRNNSPLFSIC-SHTSGLGFMFSCLLG 1234

  Fly   206 VCISNSACLFDF--------GFVTG------QDVLLSFST----IDWSAGM----------FNML 242
            :....|.|||..        .|:.|      :|:.|...|    :|.::.:          .|..
Yeast  1235 IYTGASTCLFSLTDVLTDPKEFLIGLQNLNVKDLYLKLETLYALLDRASSLIEGFKNKKENINSA 1299

  Fly   243 FSCCHGSTR---------IITDRPYTPE-YMIQ-LVEKYKV-----TLLTVVPQ-------QVAS 284
            .:...||.|         |:...|..|. |.|: ::::|..     |.::.|.|       .:.|
Yeast  1300 KNNTSGSLREDVFKGVRNIMIPFPNRPRIYTIENILKRYSTISLSCTQISYVYQHHFNPLISLRS 1364

  Fly   285 LLKTPTLN------KQRLASIRFVSVGGGSCYVANLLKLQEFLITGQISYGYALTECGGVAANMG 343
            .|..|.::      ..|...||.|:....|  ..|.:|:|:   :|.:.          |..::.
Yeast  1365 YLDIPPVDLYLDPFSLREGIIREVNPNDVS--AGNYIKIQD---SGVVP----------VCTDVS 1414

  Fly   344 VAKPSSVGRIVPGVRVKILDEAGRSLGHGETGEI-LVHNGKVWNGYYANPNESKRMQD------- 400
            |..|.:   ::|.|             .||.||| .......::.:..|.:::|..:|
Yeast  1415 VVNPET---LLPCV-------------DGEFGEIWCCSEANAFDYFVCNSSKNKLYKDPFITEQF 1463

  Fly   401 ----------YQGWFHTGDMGYFDNE------------NYLHIVERKEDLLRFHGAQYSPQEIEQ 443
                      ...:..|||:|:..|.            |.|.::....:.:...|..:...::|:
Yeast  1464 KSKMKSEVNNTLSYLRTGDLGFIKNVSCTNSQGEVVNLNLLFVLGSIHESIEILGLTHFVSDLER 1528

  Fly   444 VIAELPDVIEACVF----GL----------WNEVDGDPAAAAVVKIPGSRLTEMDIVEYVAKRLV 494
            .:.::...|.:|:.    ||          .|.:.|:.....|.::.......:|:..:|..:
Yeast  1529 TVKDVHSDIGSCLIAKAGGLLVCLIRCKERHNPILGNLTTLIVSELLNKHGVILDLCTFVRTK-- 1591

  Fly   495 VDHKQLHCGVFFLPELPKTGSGKVLRQQARDQA-LGKKWAD 534
                    |:     .|| .|..::...|:::| :.:.|.|
Yeast  1592 --------GI-----SPK-NSSMIMEVWAKNRASIMQAWFD 1618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	128/685 (19%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	120/656 (18%)
CMR2	NP_014736.1	DMAP_binding	5..121	CDD:368923
		AFD_class_I	179..893	CDD:418409
		Dip2	1004..1626	CDD:341231	122/667 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900