Protein Alignment CG11453 and AACS

DIOPT Version :9

• Sequence 1: NP_650832.1
• Gene: CG11453 / 42355
• FlyBaseID: FBgn0038734
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_076417.2
• Gene: AACS / 65985
• HGNCID: 21298
• Length: 672
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 117/546 - (21%)
• Similarity: 216/546 - (39%)
• Gaps: 125/546 - (22%)

  Fly    69 AQQLKAMGLKQDD-VVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIF 132
            |..::.||:|:.| |||.: .|:.:.:..:|.....|..:.:.||....:.:...||..:|||||
Human   142 AAAMRKMGVKKGDRVVGYL-PNSEHAVEAMLAAASIGAIWSSTSPDFGVNGVLDRFSQIQPKLIF 205

  Fly   133 C------DGKCFQRLSIIARILKS---------HVYTLKDHRLGMPRV------EDLLEPTTAEL 176
            .      :||....:..:.:::|.         ..|......:.:.::      :|.|...|:|.
Human   206 SVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIPYVSSRENIDLSKIPNSVFLDDFLATGTSEQ 270

  Fly   177 YYVPETLLLGGDHTVAILCTSGTTGLPKAVCISNSACLFD-------FGFVTGQDVLLSFSTIDW 234
            ....|...|...|.:.|:.:|||||.||.:..|....|..       .|.:|..|:||.::|:.|
Human   271 APQLEFEQLPFSHPLFIMFSSGTTGAPKCMVHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGW 335

  Fly   235 SAGMFNMLFS-CCHGSTRIITD-RPY--TPEYMIQLVEKYKVTL-------LTVVPQQVASLLKT 288
            .  |:|.:.| ...|:..::.| .|.  ||..:..||::..:|:       |:|:.::....::|
Human   336 M--MWNWMVSLLATGAAMVLYDGSPLVPTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVET 398

  Fly   289 PTLNKQRLASIRFVSVGGGSCYVANLLKLQEF----------LITGQISYGYALTEC-------- 335
            .:|  |.|.:|  :|.|       :.||.|.:          ::.|.||.|..:..|
Human   399 HSL--QMLHTI--LSTG-------SPLKAQSYEYVYRCIKSSILLGSISGGTDIISCFMGHNFSL 452

  Fly   336 ----GGV-AANMGVAKPSSVGRIVPGVRVKILDEAGRSLGHGETGEIL---------VHNGKVWN 386
                |.: |.|:|:|             |:..:|.|::: .||:||::         .|   .||
Human   453 PVYKGEIQARNLGMA-------------VEAWNEEGKAV-WGESGELVCTKPIPCQPTH---FWN 500

  Fly   387 GYYANPNESKRMQDYQG-WFHTGDMGYFDNENYLHI---------VERKEDLLRFHGAQYSPQEI 441
            ....|.........:.| |.| ||        |..|         :.|.:..|..:|.::...||
Human   501 DENGNKYRKAYFSKFPGIWAH-GD--------YCRINPKTGGIVMLGRSDGTLNPNGVRFGSSEI 556

  Fly   442 EQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEYV--AKRLVVDHKQLHCGV 504
            ..::....:|.::.....:|:. .:......:|:......:.|:|:.:  |.|:.:..:.:...:
Human   557 YNIVESFEEVEDSLCVPQYNKY-REERVILFLKMASGHAFQPDLVKRIRDAIRMGLSARHVPSLI 620

  Fly   505 FFLPELPKTGSGKVLRQQARDQALGK 530
            .....:|.|.:||.:....:....||
Human   621 LETKGIPYTLNGKKVEVAVKQIIAGK 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	115/544 (21%)
		Firefly_Luc_like	46..519	CDD:213279	115/533 (22%)
AACS	NP_076417.2	ac_ac_CoA_syn	16..670	CDD:273507	117/546 (21%)
		AACS	40..663	CDD:213308	117/546 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.861654	Normalized mean entropy	S3159
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860