DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and Acsf2

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001030123.1	Gene:	Acsf2 / 619561	RGDID:	1562656	Length:	615	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	130/570 - (22%)
Similarity:	224/570 - (39%)	Gaps:	106/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRIAQQLKAMGLKQDDVVGIVGTNTTYL 93
            ::|:.|.|..:..||....:...|...|...:......|.|..|.::||::.|.:|:.|.|:...
  Rat    73 TVGECLDATAQRFPNREALVIIHENIRLNFAQLKEEVDRAASGLLSIGLRKGDRLGMWGPNSYAW 137

  Fly    94 MPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIFCDGKCF-------QRLSIIARIL--- 148
            :.:.|.....|....:|:|......::::.     :.:.|.|..|       |..:|:.::.
  Rat   138 VLIQLATAQAGIILVSVNPAYQASELEYVL-----RKVGCKGIVFPKQFKTQQYYNILKQVCPEL 197

  Fly   149 -KSHVYTLKDHRLGMPRVEDLLEPTTAELYYVPETLLL------GGD---------HTVAILC-- 195
             |:....||..||     .||....:.:. .:|.||||      ||.         |...:.|
  Rat   198 EKAQPGALKSERL-----PDLTTVISVDA-PLPGTLLLDEVVAAGGKEQNLAQLRYHQGFLSCYD 256

  Fly   196 ------TSGTTGLPKAVCISNSACLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSC----C---- 246
                  ||||||.||...:|:...:.:...: ||.:.:...|    |....|:..|    |
  Rat   257 PINIQFTSGTTGNPKGATLSHHNIVNNSNLI-GQRLKMPAKT----AEELRMVLPCPLYHCLGSV 316

  Fly   247 --------HGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVS 303
                    ||:|.:::...:..:..::.:.:.|.|||...|.....:|..|..:.....:||
  Rat   317 GGTMVSVVHGATLLLSSPSFNGKKALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTTIR--- 378

  Fly   304 VGG---GSCYVANLLK-------LQEFLITGQISYGYALTECGGVAANMGVA-----------KP 347
             ||   ||.....|::       ::|.::.      |..||      |..|.           |.
  Rat   379 -GGVIAGSLAPPELIRAIISKMNMKELVVV------YGTTE------NSPVTFMNFPEDTLEQKA 430

  Fly   348 SSVGRIVPGVRVKILD-EAGRSLGHGETGEILVHNGKVWNGYYANPNESKRMQDYQGWFHTGDMG 411
            .|||||:|....:|:: |.|........||:.:....|..||:..|.::........|:.|||:.
  Rat   431 GSVGRIMPHTEAQIVNMETGELTKLNMPGELCIRGYCVMQGYWGEPQKTFETVGQDRWYRTGDIA 495

  Fly   412 YFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIP 476
            ..|.:.:..||.|.:|::...|....|.|:|....:.|.|.||.|.|:.::..|:...|.:....
  Rat   496 SMDEQGFCRIVGRSKDMIIRGGENIYPAELEDFFHKHPQVQEAQVVGVKDDRMGEEICACIRLKS 560

  Fly   477 GSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTGSGKVLRQQARDQ 526
            |...||.:|..:...:  :.|.::...:.|:...|.|.|||:.:.:.|:|
  Rat   561 GETTTEEEIKAFCKGK--ISHFKIPRYIVFVEGYPLTVSGKIQKFKLREQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	130/570 (23%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	123/544 (23%)
Acsf2	NP_001030123.1	PRK08315	57..615	CDD:236236	130/570 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810