DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and CG18586

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	205/533 - (38%)
Similarity:	317/533 - (59%)	Gaps:	9/533 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNRSTTQFDKYTKIWSGPRPASFFDADCSIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFA 65
            :|...|..|| .|||||....|.|..:.|||:|:|..|.|:|..|.|||.||...||..:....|
  Fly    11 LNAMCTYDDK-LKIWSGREAPSLFSPNLSIGEIIFGDMVNNPKLIAQISITEDIVLTREDLHMNA 74

  Fly    66 IRIAQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKL 130
            :|:|..::.|||.|.|:||::|.:||:...|...|..||||.||:....:|..|..||.||:|:|
  Fly    75 MRVASYMRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITKPRL 139

  Fly   131 IFCDGKCFQRLSIIARILKSHVYTLKDHRLGMPRVEDLLEPTTAELY-YVPETLLLGGDHTVAIL 194
            |||||..::::....:.|:..:.|:::|..|..|::|:|  ||..:. :.|..|..|.|||:|||
  Fly   140 IFCDGDEYEKVKSATKDLQVTIVTMRNHPRGSVRIQDVL--TTPVMQNFQPLRLKDGIDHTLAIL 202

  Fly   195 CTSGTTGLPKAVCISNS-ACLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSCCHGSTRIITDRPY 258
            .:|||:|.||||.|||| ..:.|:..:...::..:.||:||.:|:...:.|....:|.||.|..:
  Fly   203 SSSGTSGFPKAVTISNSHKIIVDYMAINNSNIQYTSSTLDWCSGLSMAITSGVFSTTSIIADCDF 267

  Fly   259 TPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYVANLLKLQEFLIT 323
            .|....:.:.||:::::.:....:|.....|......|:|:.:|..||.||.:....|::..|..
  Fly   268 DPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFESADLSSLNYVIFGGSSCSLEVQRKVRSRLSH 332

  Fly   324 GQISYGYALTE---CGGVAANMGVAKPSSVGRIVPGVRVKILDEAGRSLGHGETGEILVHNGKVW 385
            ..:::.|.|||   .|.|..|.. .||:||||.:.|:::|::||.|.:......|||..||.:.|
  Fly   333 DCLNFCYGLTELNSAGSVNLNFD-EKPNSVGRAIRGIKIKVIDEQGEAQEPNVVGEICFHNSQKW 396

  Fly   386 NGYYANPNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPD 450
            .|||.||:|::::||.:.|.||||:||.|.:.||.:::|.:|:|::....|.|.|||.||||:|:
  Fly   397 AGYYKNPDETRQIQDSENWIHTGDLGYVDKDGYLFVIDRLKDMLKYQNIMYYPSEIENVIAEMPN 461

  Fly   451 VIEACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTGS 515
            |:||||||:|:.|:||.|||::||.||::|...|:||||.||:....|||:.|...:.::.::|:
  Fly   462 VLEACVFGIWDPVNGDEAAASLVKKPGTQLEAQDVVEYVRKRITAKFKQLNGGALIVDQIVRSGN 526

  Fly   516 GKVLRQQARDQAL 528
            .|..|...::..|
  Fly   527 RKTNRSAVKEHFL 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	196/516 (38%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	183/477 (38%)
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	194/508 (38%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	183/477 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471299
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I5187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	11	10.910