DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and CG4563

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_611913.1	Gene:	CG4563 / 37901	FlyBaseID:	FBgn0035006	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	211/528 - (39%)
Similarity:	321/528 - (60%)	Gaps:	17/528 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TQFDKYTKIWSGPRPASFFDADCSIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRIAQ 70
            |.|:|.|::||||...:.:|.:.|:|:|:|..:|..|.::.||:|.:||.|||.:.:.:|.|||.
  Fly     9 TFFNKETQVWSGPPRPTVYDHNTSVGQIVFNSLRCWPTNVIQITDDDGTVLTNADMLAYATRIAL 73

  Fly    71 QLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIFCDG 135
            ..|:.||.|:|.|||:..::|:::||...|....||||||:..::...::.|:|:|:||::|.||
  Fly    74 FFKSEGLTQEDRVGIIANSSTFVIPVATACFFQATPFHAVNYSREPAIVQGLYSVTKPKIMFIDG 138

  Fly   136 KCFQRLSIIARILKSHVYTLKDHRLGMPRVEDLLEPTTAELYYVPETLLLGGDHTVAILCTSGTT 200
            ..:.|:..|.:.....:.||.....|:..:|||::|..||..|||.:|..|||....:||:|||.
  Fly   139 PDYDRIKEITKEWSPKLITLTGKVEGVTSIEDLVKPHPAEKIYVPASLATGGDQIAVVLCSSGTA 203

  Fly   201 GLPKAVCIS-------NSACLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSCCHGSTRIITDRPY 258
            ||||||.:|       ||.|:       ..|||.:.:||||..|....:.:...|.||||:.|.:
  Fly   204 GLPKAVALSHRHIASTNSLCI-------STDVLYTSATIDWMTGFSITVMNLTCGFTRIISRRTF 261

  Fly   259 TPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYVANLLKLQEFLIT 323
            :.|..:.||.|||||.|.:.|.|...|..:|....::|.|::...|.||...:|.|.:.||.|..
  Fly   262 SAETALYLVSKYKVTCLAMAPWQAYELFTSPLATSEQLESLKIAFVIGGWISLALLRRAQELLPK 326

  Fly   324 GQISYGYALTECGGVAANMGVAKPSSVGRIVPGVRVKILDEAGRSLGHGETGEILVHNGKVWNGY 388
            ..:.:.|..||.|.|..|:..:...||||:.||:|:||..|.|:.||..:|||:|:..|..|.||
  Fly   327 TYVMFSYGTTETGVVTINIDHSLECSVGRLAPGMRIKIQGEDGQQLGVNQTGEVLIDIGLKWEGY 391

  Fly   389 YANPNE-SKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVI 452
            .:||.: :..:||  ||.:.||:||||.:|.|::|:||:|||::....|.|.||||:|||||:|.
  Fly   392 LSNPEDTATTLQD--GWINLGDLGYFDEDNNLYLVDRKKDLLKYKSKHYWPNEIEQIIAELPEVE 454

  Fly   453 EACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTGSGK 517
            ..||.|:.:...||.|.|.::|..|:.:.:..::::||:|:|||:|||:.||.|:.:.||..:||
  Fly   455 HVCVVGVRDARYGDAAGALIIKKEGAEIADQKVIDHVAQRVVVDYKQLNAGVIFVDKFPKNANGK 519

  Fly   518 VLRQQARD 525
            |:|..||:
  Fly   520 VMRSLARE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	204/516 (40%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	192/480 (40%)
CG4563	NP_611913.1	CaiC	21..531	CDD:223395	204/516 (40%)
CG4563	NP_611913.1	Firefly_Luc_like	49..521	CDD:213279	192/480 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471311
Domainoid	1	1.000	215	1.000	Domainoid score	I5876
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9651
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	10	9.860