DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and CG9993

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	199/549 - (36%)
Similarity:	299/549 - (54%)	Gaps:	41/549 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 STTQFDKYTKIWSGPRPASFFDADCSIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRI 68
            ::|::|.:.||||||:...::..|.::|::....:|.:.:.:.|:.|..|..||..:.:..:.|:
  Fly     2 ASTKYDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKVMQVYDPTGEELTGSQLLEQSRRL 66

  Fly    69 AQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIFC 133
            |...:.:.|::.|||||...|||||..||:..||||||.:.:.|..|.:|..::|.||:||:|||
  Fly    67 AHAFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITKPKVIFC 131

  Fly   134 DGKCFQRLSIIARIL--KSHVYTLKDHRLGMPRVEDLL--------EPTTAELYYVPETLLLGGD 188
            |...:|.||.:...|  |:.:..|.....|:..::|||        |.|   |:..|.   |.||
  Fly   132 DLDNYQTLSAVKSSLKFKTEIILLTGTLPGVRNIQDLLADGCTGYDEKT---LFACPH---LCGD 190

  Fly   189 HTVAILCTSGTTGLPKAVCIS-----NSA---CLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSC 245
            .|..|:.:||.|||||.|..|     |||   .||     |...||..||.:.|.:.:|.:|.|.
  Fly   191 DTAFIITSSGVTGLPKGVTRSHRSLLNSAKIPQLF-----TSDTVLFCFSPLYWISCIFTLLASL 250

  Fly   246 CHGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLAS----IRFVSVGG 306
            .:|..||||:||::..|...|||:::|:.:..||..:|.|.|:|  .:|.||:    ::.....|
  Fly   251 VNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSP--ERQELAAKMQCVQSFVCSG 313

  Fly   307 GSCYVANLLKLQEFLITGQISYGYALTECGGVAANMGVAKPSSVGRIVPGVRVKILDEAGRSLGH 371
            ....:....:|.|.|...:.:..|.|||.||::.|:| ....|.||::..|:|:::|..|:|||.
  Fly   314 SKVPMGIWRQLYELLGANRFAVLYGLTETGGISKNVG-GPLGSEGRLLRNVQVRVVDPHGQSLGP 377

  Fly   372 GETGEILVHNGKVWNGYYANPNESKRMQDYQG-WFHTGDMGYFDNENYLHIVERKEDLLRFHGAQ 435
            .:||:|||.....|.|||.||.|::......| |..|||.||||:|..||...|..|:.:::...
  Fly   378 NQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSRDTDVFKYNHFP 442

  Fly   436 YSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIP---GSRLTEMDIVEYVAKRLVVDH 497
            ..|::||.||..||.|.|..|||:.:||..:..|.|||:..   |::|||.|:...||:.| .|.
  Fly   443 IYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVKGVVAQHL-SDA 506

  Fly   498 KQLHCGVFFLPELPKTGSGKVLRQQARDQ 526
            ..:..||||:..||||.:.||.|::...|
  Fly   507 FHIRGGVFFVDNLPKTQNSKVQRRKIWSQ 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	192/535 (36%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	185/498 (37%)
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	190/525 (36%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	185/497 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471344
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	1	1.000	-	-		mtm9688
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	9	8.860