DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and ACSM4

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001073923.1	Gene:	ACSM4 / 341392	HGNCID:	32016	Length:	580	Species:	Homo sapiens

Alignment Length:	498	Identity:	129/498 - (25%)
Similarity:	209/498 - (41%)	Gaps:	65/498 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 KAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKH-LFSITRPKLIFCDGK 136
            |..||::.|.:.::.........|.:.|:..|..|   .|...:.|.|. |:.:...|     .|
Human   107 KPCGLQRGDRLAVILPRIPEWWLVNVACIRTGIIF---MPGTIQLTAKDILYRLRASK-----AK 163

  Fly   137 CFQRLSIIARILKSHVY---TLKDHRLGMPR-------VEDLLEPTTAELYYVPETLLLGGDHTV 191
            |......:|..::|.|.   .||...|..|:       .::|.: ..:|.:...||   |....:
Human   164 CIVASEEVAPAVESIVLECPDLKTKLLVSPQSWNGWLSFQELFQ-FASEEHSCVET---GSQEPM 224

  Fly   192 AILCTSGTTGLPKAVCISNSACLFDFGF---------VTGQDVLLSFSTIDWSAGMFNMLFS--C 245
            .|..||||||.||....|.|:  ...||         :...|::.:.|...|.......:||  .
Human   225 TIYFTSGTTGFPKMAQHSQSS--LGIGFTLCGRYWLDLKSSDIIWNMSDTGWVKAAIGSVFSSWL 287

  Fly   246 CHGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCY 310
            |.....:.....:..:..:..:..|.:|.| ..|..|..:|....|.:.:..|:|....||..
Human   288 CGACVFVHRMAQFDTDTFLDTLTTYPITTL-CSPPTVYRMLVQKDLKRYKFKSLRHCLTGGEP-- 349

  Fly   311 VANLLKLQEFLI-TG-QISYGYALTECGGVAANM--GVAKPSSVGRIVPGVRVKILDEAGRSLGH 371
             .|...|:::.: || ::..||..||.|.:.||.  ...||.|:|:.:....|:|:||.|..|..
Human   350 -LNPEVLEQWRVQTGLELYEGYGQTEVGMICANQKGQEIKPGSMGKGMLPYDVQIIDENGNVLPP 413

  Fly   372 GETGEILVHNGKV-----WNGYYANPNESKRMQDYQGWFH-TGDMGYFDNENYLHIVERKEDLLR 430
            |:.|||.:.....     ::.|..||  .|.....:|.|: |||.|..|::.|...|.|.:|::.
Human   414 GKEGEIALRLKPTRPFCFFSKYVDNP--QKTAATIRGDFYVTGDRGVMDSDGYFWFVGRADDVII 476

  Fly   431 FHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVV------KIPGSRLTEMDIVEYV 489
            ..|.:..|.|:|..:.|.|.|:|:.|....:::.|:...|.||      .....:|| :::.::|
Human   477 SSGYRIGPFEVESALIEHPAVVESAVVSSPDQIRGEVVKAFVVLAAPFKSYNPEKLT-LELQDHV 540

  Fly   490 AKRLVVDHKQLHCGVFFLPELPKTGSGKVLRQQARDQALGKKW 532
             |:....:|... .|.|:.|||||.:||:.|...|||    :|
Human   541 -KKSTAPYKYPR-KVEFVQELPKTITGKIKRNVLRDQ----EW 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	128/494 (26%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	124/483 (26%)
ACSM4	NP_001073923.1	MACS_euk	48..577	CDD:213294	128/496 (26%)
ACSM4	NP_001073923.1	Acs	49..580	CDD:223442	129/498 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920