DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and CG12512

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	129/545 - (23%)
Similarity:	221/545 - (40%)	Gaps:	75/545 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRIAQQLKAMGLKQDDVVGI-------- 85
            :||:.|.....|..:....:|..||...:....:..|..:|...:.:||:..|.||:
  Fly    48 TIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAVGLWAPNYLHW 112

  Fly    86 --------------VGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIK--HLFSITR---PKLI 131
                          ||.|..|..|.:..||........::|    :|.|  :.:.|.|   |::.
  Fly   113 YLGMMGAARAGLTSVGLNPAYQGPEIAYCLNKVNVKAIIAP----ETFKTQNYYEILRDICPEIS 173

  Fly   132 FCD-GKC----FQRLSIIARILKSHVYTLKDHRLGMPRVEDLLEPTT----AELYYVPETLLLGG 187
            ..| ||.    |..       |:|.:....|...|..|.:|.|:..:    .|:..:.:::|  .
  Fly   174 DADTGKIRSEKFPH-------LRSVIIDSNDSLKGALRFDDFLDLASKSEREEVAKMQKSIL--P 229

  Fly   188 DHTVAILCTSGTTGLPKAVC------ISNSACLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSCC 246
            :....|..||||||.|||.|      ::|...:.:...:.|:.:.:..........:.:::.:..
  Fly   230 ESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPMFHAFGVIISIMAALT 294

  Fly   247 HGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYV 311
            .|:|.::....::|:..:|.:...|.:::...|.....|:.|....:..|..|: .:|.||:...
  Fly   295 KGATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIK-KAVTGGAIVS 358

  Fly   312 ANLLK-LQEFLITGQISYGYALTECGGV-----AANMGVAKPSSVGRIVPGVRVKILDEAGRSLG 370
            ..|:| :::.|....:...|.|||...|     ..:......:|||.:...:..|::|..||.:.
  Fly   359 PQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAKVVDAEGRCVP 423

  Fly   371 HGETGEILVHNGKVWNGYYANPNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQ 435
            .|:.||:.|.......||:.:..::|.......|..|||....:...|..||.|.:::|...|..
  Fly   424 FGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRLKEMLIRGGEN 488

  Fly   436 YSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIPGSRLTE-MDIVEYVAKRL--VVDH 497
            ..|:|||..:...|.||||.|.|:.:|..|:...|.|      ||.| :|...:.|:.|  ....
  Fly   489 IFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYV------RLEEGVDPASFTAETLKAYAKG 547

  Fly   498 KQLHCGV--FFLP--ELPKTGSGKV 518
            |..|..|  :.:|  ..|||.|||:
  Fly   548 KLAHFKVPRYVIPIDAFPKTTSGKI 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	129/545 (24%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	125/528 (24%)
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	129/545 (24%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	89/351 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810