DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and Acsf2

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_722502.1	Gene:	Acsf2 / 264895	MGIID:	2388287	Length:	615	Species:	Mus musculus

Alignment Length:	607	Identity:	131/607 - (21%)
Similarity:	234/607 - (38%)	Gaps:	122/607 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SGPRPASFFDA---------DCS----IGKILFAFMRNHPNS------ICQISDTEGTALTNGEA 61
            |.|||.|...:         :|:    ||.:  ::::.|.:|      :.:..|.......:.||
Mouse    28 SRPRPNSKLQSVRALSSGMVNCTNPLPIGGL--SYIQGHTDSHLVNTTVGECLDATAQRFPDREA 90

  Fly    62 ITFA---IRI------------AQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVS 111
            :...   ||:            |..|.::||::.|.:|:.|.|:...:.:.|.....|....:|:
Mouse    91 LVILHENIRLNFAQLKEEVDKAASGLLSIGLRKGDRLGMWGPNSYAWVLIQLATAQAGIILVSVN 155

  Fly   112 PWQDEDTIKHLFSITRPKLIFCDGKCF-------QRLSIIARIL----KSHVYTLKDHRL----- 160
            |......::::.     :.:.|.|..|       |...|:.::.    |:....||..||
Mouse   156 PAYQSSELEYVL-----RKVGCKGIVFPKQFKTQQYYDILKQVCPELEKAQPGALKSERLPDLTT 215

  Fly   161 ---------GMPRVEDLL-----EPTTAELYYVPETLLLGGDHTVAILCTSGTTGLPKAVCISNS 211
                     |...::|::     |...|:|.|  ....|.....:.|..||||||.||...:|:.
Mouse   216 VISVDAPLPGTLLLDDIVAAGGKEQNLAQLRY--NQRFLSCYDPINIQFTSGTTGNPKGATLSHH 278

  Fly   212 ACLFDFGFVTGQDVLLSFSTID--------------WSAGMFNMLFSCCHGSTRIITDRPYTPEY 262
            . :.:...:.||.:.:...|.:              .|.|  ..:.|..||:|.:::...:..:.
Mouse   279 N-IVNNSMLIGQRLKMPTKTAEELRLVLPSPLYHCLGSVG--GTMVSMMHGATLLLSSPSFNGKK 340

  Fly   263 MIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSC------YVANLLKLQEFL 321
            .::.:.:.|.|||...|.....:|..|..:.....|||...:.|...      .:.|.:.::|.:
Mouse   341 ALEAISREKGTLLYGTPTMFVDILNQPDFSSYDFTSIRGGVIAGSPAPPELIRAIINKMNMKELV 405

  Fly   322 ITGQISYGYALTECGGVAANMGVA-----------KPSSVGRIVPGVRVKILD-EAGRSLGHGET 374
            :.      |..||      |..|.           |..|||||:|....:|:: |.|........
Mouse   406 VV------YGTTE------NSPVTFMNFPEDTLEQKAGSVGRIMPHTEAQIVNVETGELTNLNVP 458

  Fly   375 GEILVHNGKVWNGYYANPNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQ 439
            ||:.:....|..||:..|.::........|:.|||:...|.:.:..||.|.:|::...|....|.
Mouse   459 GELYIRGYCVMQGYWGEPQKTFETVGQDKWYRTGDIALMDEQGFCKIVGRSKDMIIRGGENIYPA 523

  Fly   440 EIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEYVAKRLVVDHKQLHCGV 504
            |:|....:.|.|.||.|.|:.:|..|:...|.:....|...|..:|..:...:  :.|.::...:
Mouse   524 ELEDFFLKHPQVQEAQVVGVKDERMGEEICACIRLKSGETTTAEEIKAFCKGK--ISHFKIPRYI 586

  Fly   505 FFLPELPKTGSGKVLRQQARDQ 526
            .|:...|.|.|||:.:.:.|:|
Mouse   587 VFVEGYPLTISGKIQKFKLREQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	130/605 (21%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	119/549 (22%)
Acsf2	NP_722502.1	PRK08315	57..615	CDD:236236	123/578 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810