DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and ACSL1

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001273637.1	Gene:	ACSL1 / 2180	HGNCID:	3569	Length:	698	Species:	Homo sapiens

Alignment Length:	509	Identity:	119/509 - (23%)
Similarity:	188/509 - (36%)	Gaps:	139/509 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 ICQISDTEGTALTNGEAITFAIRIAQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHA 109
            :.::|:..|:||..              |......|..:||...|....:.:..||.....   .
Human   126 VAELSECIGSALIQ--------------KGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSM---V 173

  Fly   110 VSPWQD---EDTIKHLFSITRPKLIFCD-------------GKCFQRLSIIARILKSHVYTL--K 156
            :.|..|   .:.|.::.:.....|:|.|             .|....|.||. ::.::...|  :
Human   174 IVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIV-VMDAYGSELVER 237

  Fly   157 DHRLG-----MPRVEDL-----LEPTTAELYYVPETLLLGGDHTVAILC-TSGTTGLPKAVCISN 210
            ..|.|     |..:|||     .:|...    .||.|        |::| ||||||.||...:::
Human   238 GQRCGVEVTSMKAMEDLGRANRRKPKPP----APEDL--------AVICFTSGTTGNPKGAMVTH 290

  Fly   211 SACLFD-FGFVTG---------QDVLLSFSTIDWSAGMFNMLFSC---CHGS--------TRIIT 254
            ...:.| ..||..         .|.|:||..:   |.||..:..|   |||:        .|::.
Human   291 RNIVSDCSAFVKATENTVNPCPDDTLISFLPL---AHMFERVVECVMLCHGAKIGFFQGDIRLLM 352

  Fly   255 DRPYTPEYMIQLVEKYKVTLLTVVPQ-----------QVASLLKTPTL---NKQRLASIRF---- 301
            |.          ::..:.|:..|||:           |..:.||...|   :|::.|.:|.
Human   353 DD----------LKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIR 407

  Fly   302 --------------VSVGG-------GSCYV-ANLLKLQEFLITGQISYGYALTEC-GGVAANM- 342
                          .|:||       |:..| |.:|......:..|...||..||| .|....|
Human   408 NNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMP 472

  Fly   343 GVAKPSSVGRIVPGVRVKILD--EAGRSLGHGETGEILVHNGKVWNGYYANPNESKRMQDYQGWF 405
            |......||..:|...:|::|  |.......|| ||:.|....|:.||..:|.::....|..||.
Human   473 GDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGE-GEVCVKGPNVFQGYLKDPAKTAEALDKDGWL 536

  Fly   406 HTGDMGYFDNENYLHIVERKEDLLRFHGAQY-SPQEIEQVIAELPDVIEACVFG 458
            ||||:|.:.....|.|::||:.:.:....:| :|::||.:......|.:..|.|
Human   537 HTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHG 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	119/509 (23%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	119/508 (23%)
ACSL1	NP_001273637.1	LC-FACS_euk	116..694	CDD:341250	119/509 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149109
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930