DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and ACSF3

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_005256350.1	Gene:	ACSF3 / 197322	HGNCID:	27288	Length:	610	Species:	Homo sapiens

Alignment Length:	505	Identity:	115/505 - (22%)
Similarity:	198/505 - (39%)	Gaps:	108/505 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 TNGEAITFAIRIAQQLKAM------GLKQDDVVGIVGTNTTYLMPVVLGCLLNG--TPFHAVSPW 113
            |..|..:.::|::|::..:      .|:::.|..:...:.:|::......:..|  .|.:...|
Human    67 TYRELYSRSLRLSQEICRLCGCVGGDLREERVSFLCANDASYVVAQWASWMSGGVAVPLYRKHP- 130

  Fly   114 QDEDTIKHLFSITRPKLIFCDGKCFQRLSIIARILKSHVYTLKDHRLGMPRVEDLLEPTTAELYY 178
              ...::::...::..::....:..:.||.:.|            :||:|     |.|.|..:|.
Human   131 --AAQLEYVICDSQSSVVLASQEYLELLSPVVR------------KLGVP-----LLPLTPAIYT 176

  Fly   179 ----------VPETLLLGGDHTVA-ILCTSGTTGLPKAVCISNSACLFDFGFVTG---------Q 223
                      |||.   |..:..| |:.||||||.||.|..::....   ..|||         .
Human   177 GAVEEPAEVPVPEQ---GWRNKGAMIIYTSGTTGRPKGVLSTHQNIR---AVVTGLVHKWAWTKD 235

  Fly   224 DVLLSFSTIDWSAGMFNMLFSCCH---GSTRIITDRPYTPEYMIQLV-EKY------KVTLLTVV 278
            ||:|....:....|:.|.|.  |.   |:|.::     .||:..|.| ||:      ::.:...|
Human   236 DVILHVLPLHHVHGVVNALL--CPLWVGATCVM-----MPEFSPQQVWEKFLSSETPRINVFMAV 293

  Fly   279 PQQVASLLK------TPTLNKQRLAS-----IRFVSVGGGSCYVANLLKLQEFLITGQ-ISYGYA 331
            |.....|::      |....:..|.:     ||.:..|..:..:..|.|.:.  |||. :...|.
Human   294 PTIYTKLMEYYDRHFTQPHAQDFLRAVCEEKIRLMVSGSAALPLPVLEKWKN--ITGHTLLERYG 356

  Fly   332 LTECGGVAA---NMGVAKPSSVGRIVPGVRVKIL-----------------DEAGRSLGHG---E 373
            :||.|...:   ...|..|.|||..:|||:|:|:                 ||.|..:..|   :
Human   357 MTEIGMALSGPLTTAVRLPGSVGTPLPGVQVRIVSENPQREACSYTIHAEGDERGTKVTPGFEEK 421

  Fly   374 TGEILVHNGKVWNGYYANPNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSP 438
            .||:||....|:..|:..|.|:|......|||.|||...|.:..|........|:::..|.:.|.
Human   422 EGELLVRGPSVFREYWNKPEETKSAFTLDGWFKTGDTVVFKDGQYWIRGRTSVDIIKTGGYKVSA 486

  Fly   439 QEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKIPGSRLTEMDIVEY 488
            .|:|..:...|.:.:..|.|:.:...|....|.|....|..|:..::.|:
Human   487 LEVEWHLLAHPSITDVAVIGVPDMTWGQRVTAVVTLREGHSLSHRELKEW 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	115/505 (23%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	115/505 (23%)
ACSF3	XP_005256350.1	MCS	55..546	CDD:341264	115/505 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810