DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and acs-9

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_510728.2	Gene:	acs-9 / 188659	WormBaseID:	WBGene00020634	Length:	497	Species:	Caenorhabditis elegans

Alignment Length:	501	Identity:	125/501 - (24%)
Similarity:	212/501 - (42%)	Gaps:	73/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 NGEAITF------AIRIAQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDE 116
            :.:.|||      ..::..:|..:|:.|.|.:.:...|:.:...:.|.|...|.....:|.....
Worm    30 DNQVITFEEIPQLVSKLVYKLLELGISQGDTILVCLPNSIWYPLLFLSCAKIGAVLSGISHESTA 94

  Fly   117 DTIKHLFSITRPKLIFCDGKCFQRLSIIARILKSHVYTLKDHRLGM--PRVEDLLEPTTAELYYV 179
            ..||:....:..||:|.:.|          :.|.:.:.|.::.:.:  ..|:..::..|....:.
Worm    95 GEIKYSLKQSGAKLVFTNEK----------VSKENYWALSENSVEVLPDSVKTYIDRITGHEDFR 149

  Fly   180 PETLLLGGDHTVAILCTSGTTGLPK----------AVCISNSACLFDFGFVTGQDVLLSFSTIDW 234
            ||.|.:  |..:....:|||||.||          |...|....|||..........|:|.....
Worm   150 PENLDI--DSILLAPFSSGTTGAPKCCLLTHRNFLAATYSLKKFLFDQLLAQSSMKTLAFLPFHH 212

  Fly   235 SAGMFNMLFSCCHGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASI 299
            ::|.:.:|.....|.|..|... :.|..|:.|:|||::..:.:|| .:|::.....:.:.|..|:
Worm   213 ASGFWALLICLLEGCTTYIMSE-FHPIVMMDLIEKYEIDTINIVP-PIANIFLKMGILQGRCPSL 275

  Fly   300 RFVSVGGGSCYVANLLKLQEFLITGQISY---GYALTECGGVAANMGVAKP--------SSVGRI 353
            |.:..|..........:|  ..|..|:::   ||.:||    ...:....|        .|.|.|
Worm   276 RTILCGSSGLQKDRCKRL--LSIFPQVTHFIQGYGMTE----LVVLSCVTPFDDNFEHLGSCGHI 334

  Fly   354 VPGVRVKILDEAGRSLGHGETGEILVHNGKVWNGY-YANPNESKRMQDYQGWFHTGDM-----GY 412
            :||...|:.:..     .||| |:.:.:..:...| ...||     .|...|.||||:     |:
Worm   335 LPGFETKLFEHP-----TGET-ELWLKSDAIMKAYKNGTPN-----LDEDDWLHTGDIVTEKGGF 388

  Fly   413 FDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGD-PAAAAVVKIP 476
            |      ::|:|.:||::.:|.|.||.|||.||..||.|.|..|.|:.:|:.|. |.|..|::..
Worm   389 F------YVVDRMKDLIKLNGYQVSPTEIENVILTLPKVAEVAVVGIEDELCGQLPKAYIVLEKN 447

  Fly   477 GSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTGSGKVLRQQ 522
            ...|..:..:|:..|..:...|||..||..:.|:||:.|||:.:.:
Worm   448 ADELLFLKHLEHTMKEKLSAVKQLRGGVSIIKEMPKSSSGKIQKNR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	125/501 (25%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	125/496 (25%)
acs-9	NP_510728.2	CaiC	1..494	CDD:223395	125/501 (25%)
acs-9	NP_510728.2	Firefly_Luc_like	26..490	CDD:213279	125/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880