DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and mec-18

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_508731.3	Gene:	mec-18 / 180701	WormBaseID:	WBGene00003179	Length:	638	Species:	Caenorhabditis elegans

Alignment Length:	595	Identity:	125/595 - (21%)
Similarity:	243/595 - (40%)	Gaps:	106/595 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WSGPRPASFFDADCSIGKILFAFMRNHPNSICQISDTEGTALTNGEAITFAIRIAQQLKAMGLKQ 79
            |......||.|       ..|:.:..|.:::..:....|......|...:....|.:||.:.:..
Worm    11 WDKTAAQSFHD-------YFFSKISAHGSNLAIVDVDSGKQWRYSEIRNWCEMCATRLKELQVTS 68

  Fly    80 DDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIFCDGKCFQRLSII 144
            ...|.::...|...:.|.|.|.:.|....||:.|...|.|..|..::....:..:.:..|:...:
Worm    69 GSRVAVITGTTGQAIFVHLACSIIGCSAVAVNGWNAVDEIWTLVDLSEATHLIVENQFMQKADDV 133

  Fly   145 ARILK-------SHVYTLKD----HRLGM--------------PRVEDL------LEPTTAELYY 178
            .|..:       .||..::|    .|:.:              |.|:::      |.|.
Worm   134 RRKAQMRGGGRIKHVRQIEDVLTAERINVDSARKRSIDVKQKPPLVKEMSLAKINLTPV------ 192

  Fly   179 VPETLL------------------------------------LGGDHTVAILCTSGTTGLPKAVC 207
            :||.:.                                    :.|.:.:.||.|||||||.||..
Worm   193 LPEDIADLTSPVSEVSGQSKELNGDVESSVVDSEEVQTPIQQVSGQNPLLILFTSGTTGLAKAAE 257

  Fly   208 ISNSACLFD--------FGFVTGQDVLLSFSTIDWSAGMFNMLFSCCHGSTRIITDRPYTPEYMI 264
            :|:.:.:.:        :|.|..::..|...:|....|:.:..::..:|::..:..:.....:|.
Worm   258 LSHRSLIINIQQISLPLYGPVQTKERFLLPLSIAHIYGIVSAYYALINGASLYLISKQSNRLFME 322

  Fly   265 QLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGG------GSCYVANLLKLQEFLIT 323
            .||.. ::.::.:.|..|..:.....::..:..::|.|...|      .:..:.:.|.:::|
Worm   323 TLVNN-QINVMHITPAIVHWMATDAIVDDYKTPNLRSVLCAGAPIDSNSAAAMKSRLNIKDF--- 383

  Fly   324 GQISYGYALTECGGVAANMGV--AKPSSVGRIVPGVRVKILD-EAGRSLGHGETGEILVHNGKVW 385
             :.|:|  :||.||:......  .|..|||..:||:..|::: |..:.....:.|:|:|...:|.
Worm   384 -RQSFG--MTELGGICTMSPYLDEKIESVGNPLPGMLFKVVNWETKQLCLPRQPGQIIVLGPQVS 445

  Fly   386 NGYYANPNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPD 450
            ..||.||..:..:.|..|:..|||.|::|....:::::|.:|:::..|....|.|:|.|:.....
Worm   446 PCYYKNPKATSELFDATGFVKTGDAGFYDEVGRIYVLDRIKDIIKCKGTMICPSEVELVLRAHAG 510

  Fly   451 VIEACVFGLWNEVDGDPAAAAVVK-IPGSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTG 514
            :.:..|.|..:.|.|:..||.||| .....|...::.:||:.: :...|:|..||||:.|:|::.
Worm   511 IDDCAVVGRQDHVTGEVPAAFVVKNAQHPLLASAEVRQYVSGK-IATFKELRGGVFFISEIPRSV 574

  Fly   515 SGKVLRQQAR 524
            .||:||:..|
Worm   575 CGKILRRNLR 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	124/592 (21%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	116/557 (21%)
mec-18	NP_508731.3	CaiC	12..585	CDD:223395	124/594 (21%)
mec-18	NP_508731.3	AFD_class_I	35..579	CDD:302604	116/557 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.880