DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11453 and acs-14

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_505451.1	Gene:	acs-14 / 179330	WormBaseID:	WBGene00008669	Length:	544	Species:	Caenorhabditis elegans

Alignment Length:	515	Identity:	133/515 - (25%)
Similarity:	231/515 - (44%)	Gaps:	65/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 ITF------AIRIAQQLKAMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIK 120
            |||      |..:|..|.::|.|: ||..:|..|..:.....:||.:||......|....:..::
Worm    48 ITFEQLRKDAFAVAMYLHSIGFKK-DVAAVVLPNVWHYTSFFIGCAINGGAVSGASALFTDYELQ 111

  Fly   121 HLFSITRPKLIFC-------------DGKCFQRLSIIARILKSHVYTLKDHRLGMPRVEDLLE-P 171
            ..|..:|.|::|.             .....|::.:|.:.:.|.:      ..|:....:::. |
Worm   112 RQFVDSRAKVVFTYEDFLPKVLLAVKQSPNIQKIIVIPKPVGSSL------PAGVVSWNEVVSTP 170

  Fly   172 TTAELYYVPETLLLGGDHTVAILCTSGTTGLPKAVCIS--NSACLFDFGFVTGQDVLLSFSTIDW 234
            .||    :|:..:...:..:.:..:|||||.||.|.:|  |...:........:..:|.....:|
Worm   171 VTA----LPQVPIDVHNDLLVLPYSSGTTGPPKGVMLSHYNFTSMISMYLAIDKSHILDVLDPNW 231

  Fly   235 SA---------------GMFNMLFSC-CHGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVA 283
            ..               | |.:|..| ..|.|.|:... :.|...:..|:.|||..|.:||..:.
Worm   232 DCYNEKALLFLPFYHVYG-FGLLNHCLLKGMTGIVMSH-FEPNNFLTAVQNYKVRCLCLVPPIMV 294

  Fly   284 SLLKTPTLNKQRLASIRFVSVG---GGSCYVANLLKLQEFLITGQISYGYALTECGGVAANMGVA 345
            .|.|.|..:|..|:|::.:..|   .|...:..|.:  ::.....|..||.:||| .:|:::...
Worm   295 FLAKHPICDKFDLSSVQMIMAGAAPAGKDLIEELKR--KYTNLKYIQQGYGMTEC-SMASHLPDL 356

  Fly   346 KP----SSVGRIVPGVRVKILDE-AGRSLGHGETGEILVHNGKVWNGYYANPNESKRMQDYQGWF 405
            :.    .|||::...:.:||::. ..|.....:.|||.|....:..||...| |:.......||.
Worm   357 RNDQPYGSVGKLASNLVMKIVEPGTDREQPVNQRGEICVRGPTIMLGYLGRP-EATASTVIDGWL 420

  Fly   406 HTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAA 470
            ||||:||.:.:..|.||:|.::|::..|.|..|.|:|.::...|.:.:..|.|:.:...|:...|
Worm   421 HTGDIGYLNEDGNLFIVDRLKELIKVKGLQVPPAELEDLLLSHPKIRDCAVIGIPDAKAGELPKA 485

  Fly   471 AVVKIPGSRLTEMDIVEYVAKRLVVDHKQLHCGVFFLPELPKTGSGKVLRQQARDQALGK 530
            .||:...: |||.::.::| |..|..:|||..||.|:.|:||:.:||:||:..||::..|
Worm   486 FVVRADNT-LTEQEVKDFV-KPKVSPYKQLEGGVEFIEEIPKSAAGKILRRFLRDRSSAK 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	132/513 (26%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	128/502 (25%)
acs-14	NP_505451.1	CaiC	12..539	CDD:223395	131/509 (26%)
acs-14	NP_505451.1	Firefly_Luc_like	37..532	CDD:213279	128/502 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920