DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and acs-1

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001023937.1	Gene:	acs-1 / 179043	WormBaseID:	WBGene00018488	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	132/577 - (22%)
Similarity:	219/577 - (37%)	Gaps:	104/577 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CSIGKILFAFMRNHPNS-ICQISD-------TEGTALTNGEAITFAIRIAQQLKAMGLKQDDVVG 84
            ||...:||..:.:...| :.|:.|       .||...|..:..|.|..:|..|..:|||:.|.:|
Worm    58 CSTVPLLFETVGDRLRSAVDQVPDKEFLIFKREGIRKTYSQVATDAENLACGLLHLGLKKGDRIG 122

  Fly    85 IVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFS-------ITRP-----------KLI 131
            |.|.||...........|.|.....::|....:.:::...       ||.|           |.|
Worm   123 IWGPNTYEWTTTQFASALAGMVLVNINPSYQSEELRYAIEKVGIRALITPPGFKKSNYYQSIKDI 187

  Fly   132 FCD------GK---------CFQRLSIIARILKSH----VYT------LKDHRLGMPRVEDLLEP 171
            ..:      ||         |||.|.:.....|.:    .||      .::.|..:.::|...:|
Worm   188 LPEVTLKEPGKSGITSRNFTCFQHLIMFDEEDKIYPGAWKYTDVMKMGTEEDRHHLSKIERETQP 252

  Fly   172 TTAELYYVPETLLLGGDHTVAILCTSGTTGLPKAVCISNSACL---FDFGFVTGQDVLLSFSTID 233
                            |.::.|..||||||.||...:::...|   |..|...|.....:...|.
Worm   253 ----------------DDSLNIQYTSGTTGQPKGATLTHHNVLNNAFFVGLRAGYSEKKTIICIP 301

  Fly   234 WSAGMFNMLFSC--C---------HGSTRIITDRPYTPEYMIQLVEKYKVTLLTVVPQQVASLLK 287
                  |.|:.|  |         |..|.:.....:.....:|.:.:.|.|.|...|.....::.
Worm   302 ------NPLYHCFGCVMGVLAALTHLQTCVFPAPSFDALAALQAIHEEKCTALYGTPTMFIDMIN 360

  Fly   288 TPTLNKQRLASIRFVSVGGGSCYVANLLKL-QEFLITG-QISYGYALTECGGVAANMGVAKP--- 347
            .|........|||...:.|..|.:....:| |:..:|. |:.||  .||...|:.......|
Worm   361 HPEYANYNYDSIRSGFIAGAPCPITLCRRLVQDMHMTDMQVCYG--TTETSPVSFMSTRDDPPEQ 423

  Fly   348 --SSVGRIVPGVRVKILDEAGRSLGHGETGEILVHNGKVWNGYYANPNESKRMQDYQGWFHTGDM 410
              .|||.|:..:...|:|:....:..|..||::|....|...|:.:..::|:......|:||||:
Worm   424 RIKSVGHIMDHLEAAIVDKRNCIVPRGVKGEVIVRGYSVMRCYWNSEEQTKKEITQDRWYHTGDI 488

  Fly   411 GYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVKI 475
            ....:...:.||.|.:|::...|....|.|:||.:.:...|.:..:.|:.:|..|: ...|.|::
Worm   489 AVMHDNGTISIVGRSKDMIVRGGENIYPTEVEQFLFKHQSVEDVHIVGVPDERFGE-VVCAWVRL 552

  Fly   476 PGS---RLTEMDIVEYVAKRLVVDHKQLHCGVFFLP--ELPKTGSGKVLRQQARDQA 527
            ..|   :.||.||..:...::.  |.::...:.|..  |.|.|.:|||.:.:.|:.:
Worm   553 HESAEGKTTEEDIKAWCKGKIA--HFKIPRYILFKKEYEFPLTVTGKVKKFEIREMS 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	132/577 (23%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	125/548 (23%)
acs-1	NP_001023937.1	PRK08315	53..615	CDD:236236	132/577 (23%)
acs-1	NP_001023937.1	FACL_like_2	252..604	CDD:213284	89/378 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910