DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and acs-21

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_503845.1	Gene:	acs-21 / 178751	WormBaseID:	WBGene00016849	Length:	517	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	138/529 - (26%)
Similarity:	223/529 - (42%)	Gaps:	89/529 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 IGKILFAFMRNHPNSICQISDTEGTALTNGEAI----TFAIRIAQQLKAMGLKQDDVVGIVGTNT 90
            |.|:||            |.|  |..:|.|:.:    .:|..:.::.|   :|:.|.|....:.|
Worm    36 ISKVLF------------IDD--GRKITYGDFVQRAGQYATALTEKYK---IKKGDRVMARVSKT 83

  Fly    91 TYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKL-IFCDGKCFQRLSIIARILKSHVYT 154
            |....:...||..|..:..|:|...:....|.....:|.| |.|.....| :::..|:||:..
Worm    84 TDTAALYAACLQIGALYVPVNPALTQSEAAHYVKDAKPSLWITCKDDADQ-IAMFQRVLKTVC-- 145

  Fly   155 LKDHRLGMPRVEDLLEPTTAE----------LYYVPETLLLGGDHTVAILC-TSGTTGLPKAVCI 208
                 :..| ||.:.|...|:          :.:|.::       ..|.:| ||||||.||...:
Worm   146 -----IDNP-VEVINEKVLADEAGKRKACTMIEHVEKS-------NAATICFTSGTTGAPKGAVL 197

  Fly   209 SN-------SACLFDFGFVTGQDVLLSFSTIDWSAGMFNMLFSCCHGSTRIITDRPYTPEYMIQL 266
            |:       :|.:.::|| |..||.|....|..:.|::..|.......:.:|    :.|.:..:.
Worm   198 SHGALTNNTNALVQEWGF-TENDVNLHCLPIFHAHGLYFSLHCSLFSHSSVI----WRPNFDAED 257

  Fly   267 VEKY--KVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYVANLLKLQEFLITGQ-ISY 328
            ..|:  ..|:...||...:.||.|...||:....||....|.....|..|.:.::  .||| |..
Worm   258 CSKHLKNATVFMGVPTFYSRLLATNNFNKESFEKIRLFISGSAPLSVPTLEEFEK--RTGQVILE 320

  Fly   329 GYALTECGGVAAN--MGVAKPSSVGRIVPGVRVKILDEAGRSLGHGETGEILVHNGKVWNGYYAN 391
            .|.:||.|.:|:|  .|..|..:||:.:.||:.::.          |.|||.:.:..:::.|:.|
Worm   321 RYGMTEAGVIASNPLKGKRKAGTVGQALKGVQCRVT----------ENGEIEIKSDSIFSEYWKN 375

  Fly   392 PNESKRMQDYQGWFHTGDMGYFDNENYLHIVERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACV 456
            |.::|......|||.|||:|..|.:.||.|..|.:|::...|....|:|||..|..:..|.|:.|
Worm   376 PEKTKEEFTEDGWFKTGDVGSLDKDGYLTIGGRSKDMIISGGENIYPKEIEDAIDSIEFVKESAV 440

  Fly   457 FGLWNEVDGDPAAAAVV---KIPGSRLTEMDIVEYVAKRLV---VDHKQLHCGVFFLPELPKTGS 515
            ....:...|:...|.||   .:...:..|.|::|.:.|:|.   |..|     |..|.|||:...
Worm   441 IAAPHPDFGEAVVAVVVPKNMVEDEQKFEEDLIEMLRKKLAKYKVPKK-----VILLEELPRNHI 500

  Fly   516 GKVLRQQAR 524
            .||.:...|
Worm   501 TKVRKDILR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	138/529 (26%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	132/506 (26%)
acs-21	NP_503845.1	MCS	38..505	CDD:213307	136/521 (26%)
acs-21	NP_503845.1	PRK07514	40..517	CDD:181011	136/525 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810