DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11453 and ACSM2A

DIOPT Version :9

Sequence 1:	NP_650832.1	Gene:	CG11453 / 42355	FlyBaseID:	FBgn0038734	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001295101.1	Gene:	ACSM2A / 123876	HGNCID:	32017	Length:	577	Species:	Homo sapiens

Alignment Length:	513	Identity:	131/513 - (25%)
Similarity:	207/513 - (40%)	Gaps:	90/513 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 AMGLKQDDVVGIVGTNTTYLMPVVLGCLLNGTPFHAVSPWQDEDTIKHLFSITRPKLIFCDGKCF 138
            |.||::.|.|.:|.........|:|||:..|..|...:.......|.:...:::.|.|....:..
Human   100 ACGLQRGDRVAVVLPRVPEWWLVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVI 164

  Fly   139 QRLSIIARILKSHVYTLKDHRL-------GMPRVEDLL-EPTTAELYYVPETLLLGGDHTVAILC 195
            |.:..:|    |...:|:...|       |....:.|| |.:|.  ::..||   |.....||..
Human   165 QEVDTVA----SECPSLRIKLLVSEKSCDGWLNFKKLLNEASTT--HHCVET---GSQEASAIYF 220

  Fly   196 TSGTTGLPKAVCISNSA----CLFDFGFVTG---QDVLLSFSTIDWSAGMFNMLFSCCH----GS 249
            ||||:||||....|.|:    ...|.|: ||   .|::.:.|...|   :.|:|.|...    |:
Human   221 TSGTSGLPKMAEHSYSSLGLKAKMDAGW-TGLQASDIMWTISDTGW---ILNILCSLMEPWALGA 281

  Fly   250 TRIITDRP-YTPEYMIQLVEKYKVTLLTVVPQQVASLLKTPTLNKQRLASIRFVSVGGGSCYVAN 313
            ...:...| :.|..:::.:..|.:..:...|.....||      :|.|:|.:|.       ::.|
Human   282 CTFVHLLPKFDPLVILKTLSSYPIKSMMGAPIVYRMLL------QQDLSSYKFP-------HLQN 333

  Fly   314 LLKLQEFLI----------TG-QISYGYALTECG---GVAANMGVAKPSSVGRIVPGVRVKILDE 364
            .:.:.|.|:          || .|...|..||.|   .|:..|.: ||..:|.......|:|:|:
Human   334 CVTVGESLLPETLENWRAQTGLDIRESYGQTETGLTCMVSKTMKI-KPGYMGTAASCYDVQIIDD 397

  Fly   365 AGRSLGHGETGEILVHNGK-----VWNGYYANPNESKRMQDYQG--WFHTGDMGYFDNENYLHIV 422
            .|..|..|..|:|.:....     :::||..||:  |...:.:|  |. .||.|..|.:.|...:
Human   398 KGNVLPPGTEGDIGIRVKPIRPIGIFSGYVDNPD--KTAANIRGDFWL-LGDRGIKDEDGYFQFM 459

  Fly   423 ERKEDLLRFHGAQYSPQEIEQVIAELPDVIEACVFGLWNEVDGDPAAAAVVK---IPGSRLTEMD 484
            .|..|::...|.:..|.|:|..:.|.|.|:|..|..     ..||....|||   :..|:....|
Human   460 GRANDIINSSGYRIGPSEVENALMEHPAVVETAVIS-----SPDPVRGEVVKAFVVLASQFLSHD 519

  Fly   485 IVEYVAKRLVVDHKQLHC------GVFFLPELPKTGSGKVLRQQARDQALGKKWADHG 536
             .|.:.|.|....|.:..      .:.|:..||||.:||:.|.:.||    |:|...|
Human   520 -PEQLTKELQQHVKSVTAPYKYPRKIEFVLNLPKTVTGKIQRAKLRD----KEWKMSG 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11453	NP_650832.1	CaiC	18..530	CDD:223395	128/505 (25%)
CG11453	NP_650832.1	Firefly_Luc_like	46..519	CDD:213279	125/494 (25%)
ACSM2A	NP_001295101.1	AFD_class_I	40..568	CDD:388389	129/507 (25%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	469..471		0/1 (0%)
		Coenzyme A binding. /evidence=ECO:0000269\|PubMed:19345228	540..542		0/1 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920