DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11407 and DIP2B

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_775873.2	Gene:	DIP2B / 57609	HGNCID:	29284	Length:	1576	Species:	Homo sapiens

Alignment Length:	627	Identity:	138/627 - (22%)
Similarity:	233/627 - (37%)	Gaps:	165/627 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IGEIIFNEMRRHPQLIAQI-----------------SATENTILTRA--ELQANAMHIASYMRSL 76
            :|:|..|::.|..|.:|:|                 :|...|:.|.:  :|...|..|||.:...
Human   976 LGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRAERIASVLGDK 1040

  Fly    77 GLLQM-DIVGIIARNTTHISAVAYACFFNGI------AFHSLNISYEQSTIEKLFSITRPNIIFC 134
            |.|.. |.|.::......:.|..|.|.:.|.      ..|:.|::....|:..:..:::...|..
Human  1041 GHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATLPTVRMIVDVSKAACILT 1105

  Fly   135 DGDEFEKVRS--ATAQLDVK----IITMRNHPSGSIRIDQVLSTPIEKNFQPVRLEQGNDQTLAI 193
            .......:||  |.|.:|||    ||...:.|..  |:.|:...|             ..:.||.
Human  1106 SQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRK--RLPQLYKPP-------------TPEMLAY 1155

  Fly   194 L-CSSGTTGIPKAVTITNS------RQI-----LNSSHSLTTNDVQYSHSTLDWITGL------L 240
            | .|..|||:...|.:::|      |.|     |.||..:..        .||...||      |
Human  1156 LDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAI--------CLDPYCGLGFALWCL 1212

  Fly   241 TTVTSG---VFSTKRIIADNIFDPEFFMRLVEEHQITWIIQAPAHMAM-------MVNSPSFTTS 295
            .:|.||   |......:.:|:|   .::..|.:::|.....:.:.|.:       .|........
Human  1213 CSVYSGHQSVLIPPMELENNLF---LWLSTVNQYKIRDTFCSYSVMELCTKGLGNQVEVLKTRGI 1274

  Fly   296 DLSSLR-YYLFGGSRASVETQHRIRSRLSKD--------------------CLHFAYG------F 333
            :||.:| ..:....|..|..|... |:|.||                    ||....|      :
Human  1275 NLSCVRTCVVVAEERPRVALQQSF-SKLFKDIGLSPRAVSTTFGSRVNVAICLQGTSGPDPTTVY 1338

  Fly   334 TELGSMAALNLHFDEK--PNSV-----GRLVAGLKLKVICEKGESLGPDEVGELCLWNGQYW--- 388
            .:|.|:....:...|:  |.|:     |:::.|:|:.::  ..|:.||  ||:..|  |:.|
Human  1339 VDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIV--NPETKGP--VGDSHL--GEIWVNS 1397

  Fly   389 ----AGYYGNPEETHKMRDHHN------------WFHTGDLGYV----------DDDGFIYIVER 427
                :|||...:......||.|            |..||.||:|          :....:|:|..
Human  1398 PHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTGYLGFVRRTELTAATGERHDALYVVGA 1462

  Fly   428 KKDMLKFQNIMYYPNEIESVISKMPDVVEVCVFGVWNEINGDEATAAVVKKRGSALTAQDIVDYV 492
            ..:.|:.:.:.|:|.:||:.:|::...:..|....|..:     ...||:..||...|.|:|..|
Human  1463 LDETLELRGLRYHPIDIETSVSRIHRSIAECAVFTWTNL-----LVVVVELCGSEQEALDLVPLV 1522

  Fly   493 ETHIDAKYKQLNGGAIIVED---LVRSPNGKTNRMANKAFFL 531
             |::..:...|..|.::|.|   :..:..|:..||..:..||
Human  1523 -TNVVLEEHYLIVGVVVVVDPGVIPINSRGEKQRMHLRDSFL 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	134/617 (22%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	129/600 (22%)
DIP2B	NP_775873.2	DMAP_binding	14..131	CDD:283995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	217..246
		CaiC	336..912	CDD:223395
		AFD_class_I	360..924	CDD:302604
		AMP-binding	995..1470	CDD:278902	106/507 (21%)
		AFD_class_I	1012..1565	CDD:302604	131/591 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810