DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11407 and CG12512

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_608924.1	Gene:	CG12512 / 33766	FlyBaseID:	FBgn0031703	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	132/570 - (23%)
Similarity:	232/570 - (40%)	Gaps:	77/570 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 HLSIGEIIFNEMRRHPQLIAQ--------ISATENTILTRAELQANAMHIASYMRSLGLLQMDIV 84
            |:....:::..:.:..:|.|.        :|..|....:...|...|..:|:..|.|||...|.|
  Fly    38 HIGKDPLVYRTIGQQLELSASNFGDVEAIVSCHEGKRYSFKSLLQEADALAAGFRKLGLQPGDAV 102

  Fly    85 GIIARNTTH----ISAVAYACFFNGIAFHSLNISYEQSTI--------------------EKLFS 125
            |:.|.|..|    :...|.|    |:....||.:|:...|                    :..:.
  Fly   103 GLWAPNYLHWYLGMMGAARA----GLTSVGLNPAYQGPEIAYCLNKVNVKAIIAPETFKTQNYYE 163

  Fly   126 ITR---PNIIFCD-----GDEFEKVRSATAQLDVKIITMRNHPSGSIRIDQVLSTPIEKNFQPVR 182
            |.|   |.|...|     .::|..:||.       ||...:...|::|.|..|....:...:.|.
  Fly   164 ILRDICPEISDADTGKIRSEKFPHLRSV-------IIDSNDSLKGALRFDDFLDLASKSEREEVA 221

  Fly   183 LEQGN---DQTLAILCSSGTTGIPKAVTITNSRQILNSSHSLTTNDVQYSH--------STLDWI 236
            ..|.:   :....|..:|||||.|||..:|:...:.|..|....|:::...        .....|
  Fly   222 KMQKSILPESACNIQFTSGTTGNPKAACLTHHNFVNNGIHVGNRNELEGERICVQVPMFHAFGVI 286

  Fly   237 TGLLTTVTSGVFSTKRIIADNIFDPEFFMRLVEEHQITWIIQAPAHMAMMVNSPSFTTSDLSSLR 301
            ..::..:|.|   ...::....|.|:..::.:...:.:.|...|.....:||:.......|..::
  Fly   287 ISIMAALTKG---ATMVLPAAGFSPKDSLQAIVNEKCSVIHGTPTMYVDLVNTQKKLQVPLGRIK 348

  Fly   302 YYLFGGSRASVETQHRIRSRLSKDCLHFAYGFTELGSMAALNLHFDEKP---NSVGRLVAGLKLK 363
            ..:.||:..|.:....:|..|:.:.:|..||.||..::...:|..|...   ||||.|...::.|
  Fly   349 KAVTGGAIVSPQLIKDVRQVLNVEAVHSVYGLTETTAVIFQSLPGDSSDVVLNSVGHLTDHIEAK 413

  Fly   364 VICEKGESLGPDEVGELCLWNGQYWAGYYGNPEETHKMRDHHNWFHTGDLGYVDDDGFIYIVERK 428
            |:..:|..:...:.||||:.......||:.:.|:|.:...:..|..|||...::.:|:..||.|.
  Fly   414 VVDAEGRCVPFGQPGELCVRGYTTMLGYHDDEEKTKETIGNDRWLRTGDQFVLEANGYGRIVGRL 478

  Fly   429 KDMLKFQNIMYYPNEIESVISKMPDVVEVCVFGVWNEINGDEATAAVVKKRG---SALTAQDIVD 490
            |:||.......:|.|||..::..|.|:|..|.||.:|..|:|..|.|..:.|   ::.||:.:..
  Fly   479 KEMLIRGGENIFPKEIEDFLNAHPQVIEAHVIGVPDERLGEEVCAYVRLEEGVDPASFTAETLKA 543

  Fly   491 YVETHIDAKYKQLNGGAIIVEDLVRSPNGKTNRM----ANKAFFLEAKSS 536
            |.:..: |.:| :....|.::...::.:||..:.    |.||...|.|::
  Fly   544 YAKGKL-AHFK-VPRYVIPIDAFPKTTSGKIQKFKLVEAFKAKETELKAA 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	127/551 (23%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	125/531 (24%)
CG12512	NP_608924.1	PRK08315	43..592	CDD:236236	131/565 (23%)
CG12512	NP_608924.1	FACL_like_2	229..577	CDD:213284	86/352 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.760