DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11407 and acs-12

DIOPT Version :9

Sequence 1:	NP_650831.1	Gene:	CG11407 / 42354	FlyBaseID:	FBgn0038733	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_508035.1	Gene:	acs-12 / 180375	WormBaseID:	WBGene00009106	Length:	550	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	118/500 - (23%)
Similarity:	216/500 - (43%)	Gaps:	39/500 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 PHLSIGEIIFNEMRRHPQLIAQISATENTILTRAELQANAMHIASYMRSLGLLQMDIVGIIARNT 91
            |..:..:.:|:|..:..:.:|.|........|..::...|..||..:..|.:.:.::|.::...:
Worm    13 PDKTFHDFLFHEWEKFREDVALIDNDTFAQFTFQDVMQKADFIAKSLVYLKVEKSEVVLLVMDWS 77

  Fly    92 THISAVAYACFFNGIAFHSLNISYEQSTIEKLFSI--TRPNIIFCDG---DEFEKVRSATAQLDV 151
            .....:|......|.|...  :|.:....|..|.:  :....:|.|.   .|.:|:.. |...:.
Worm    78 PAAIYIALGASMAGAAIQV--VSPKLQAWEMQFPVKESESRFVFSDPLGLHEIDKLMK-TLNREY 139

  Fly   152 KIIT--MRNHPSGSIRIDQVLSTPIEKNFQPVRLEQGNDQTLAILCSSGTTGIPKAVTITNSRQI 214
            :||.  .|:..:|...|:. |:...::|....::|...| .:.:..|||..|..|.:..|:...:
Worm   140 RIICTGSRDFANGYPIIED-LAFAAKQNLPLPKIEPDTD-IVYLPYSSGIHGKRKGIVTTHKVMV 202

  Fly   215 L------NSS--HSLTTNDVQYSHSTLDWITGL---LTTVTSGVFSTKRIIADNIFDPEFFMRLV 268
            .      |:|  |.....|...:...|....||   |..:.:|:    .::.:..|....||..:
Worm   203 AKTMVMWNTSKHHEFRRGDTTLTMIPLHKQCGLDAILCALLNGL----TVVTEKNFCVHTFMTCI 263

  Fly   269 EEHQITWIIQAPAHMAMMVNSPSFTTSDLSSLRYYLFGGSRASVETQHRIRSRL-SKDCLHFAYG 332
            :.::|..:...|..|.:|:......|.::.||.:.:.|....:.|......... |...:...||
Worm   264 QRYKIRAVHLTPYLMNLMMFEAENHTYNIESLEWVVTGADAVTEELYEEFTEIFPSVKTVTQTYG 328

  Fly   333 FTELGSMA-ALNLHFDEKPNSVGRLVAGLKLKVI-CEKGESLGPDEVGELCLWNGQYWAGYYGNP 395
            .||:|.:. ..|.::..   |.|:|.|.|::||: ...|:.|||.|.|::|:......:.|..||
Worm   329 MTEVGLICRTYNKNYSP---SCGQLTANLEMKVLDILTGKELGPREKGQICVKGIAAESPYLNNP 390

  Fly   396 EETHKMRDH--HNWFHTGDLGYVDDDGFIYIVERKKDMLKFQNIMYYPNEIESVISKMPDVVEVC 458
            :.|   .:|  ..|..|||:|:.|::|.:::|::.|:|:|.......|.|||:::.....|.|..
Worm   391 KAT---EEHFLDGWRRTGDIGFFDEEGNVHLVDKLKEMIKVFGYQVIPKEIETLLLTHQAVEEAA 452

  Fly   459 VFGVWNEINGDEATAAVVKKRGSALTAQDIVDYVETHIDAKYKQL 503
            |..:.||::|:...|.||.|:|...|..|:.|||...: .:||.|
Worm   453 VVAINNELSGERPVAFVVLKKGFVATEDDLKDYVNKRV-IRYKHL 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11407	NP_650831.1	CaiC	26..523	CDD:223395	117/499 (23%)
CG11407	NP_650831.1	Firefly_Luc_like	47..522	CDD:213279	114/479 (24%)
acs-12	NP_508035.1	PLN02246	2..518	CDD:215137	117/499 (23%)
acs-12	NP_508035.1	Firefly_Luc_like	33..514	CDD:213279	114/479 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D683933at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920